| 1 | Juwan JohnsonNew Orleans Saints·#83 | 16 | 20 | 10 | 169 | 1 | 50.0% | 8.45 | 16.90 | 24 | 167 | 3.4 | 3 | 2 | 1 | 71 | 49 | 19 | 14 | 8 | 0 | 71 |
| 2 | Trey McBrideArizona Cardinals·#85 | 17 | 36 | 18 | 156 | 3 | 50.0% | 4.33 | 8.67 | 10 | 321 | 3.1 | 12 | 6 | 3 | 109 | 58 | 33 | 16 | 11 | 0 | 109 |
| 3 | George KittleSan Francisco 49ers·#85 | 10 | 10 | 7 | 112 | 2 | 70.0% | 11.20 | 16.00 | 4 | 123 | 2.7 | 2 | 2 | 2 | 45 | 29 | 8 | 3 | 6 | 0 | 45 |
| 4 | Kyle PittsAtlanta Falcons·#8 | 15 | 19 | 10 | 100 | 0 | 52.6% | 5.26 | 10.00 | 10 | 180 | 2.3 | 3 | 0 | 0 | 80 | 47 | 16 | 7 | 9 | 0 | 80 |
| 5 | Theo JohnsonNew York Giants·#84 | 14 | 13 | 7 | 96 | 0 | 53.9% | 7.38 | 13.71 | 10 | 166 | 3.0 | 1 | 0 | 0 | 56 | 32 | 13 | 5 | 6 | 0 | 56 |
| 6 | Oronde Gadsden IILos Angeles Chargers·#86 | 15 | 10 | 6 | 89 | 0 | 60.0% | 8.90 | 14.83 | 13 | 99 | 2.8 | 1 | 0 | 0 | 47 | 28 | 9 | 3 | 4 | 0 | 47 |
| 7 | Brock BowersLas Vegas Raiders·#89 | 11 | 16 | 10 | 86 | 3 | 62.5% | 5.38 | 8.60 | 12 | 118 | 3.3 | 7 | 4 | 3 | 43 | 23 | 15 | 4 | 7 | 0 | 43 |
| 8 | Hunter HenryNew England Patriots·#85 | 16 | 14 | 7 | 76 | 0 | 50.0% | 5.43 | 10.86 | 6 | 130 | 2.1 | 4 | 1 | 0 | 61 | 41 | 10 | 14 | 4 | 0 | 61 |
| 9 | Mark AndrewsBaltimore Ravens·#89 | 13 | 15 | 6 | 70 | 1 | 40.0% | 4.67 | 11.67 | 1 | 124 | 2.5 | 7 | 1 | 1 | 50 | 32 | 13 | 6 | 4 | 0 | 50 |
| 10 | Jake FergusonDallas Cowboys·#87 | 16 | 13 | 7 | 65 | 2 | 53.9% | 5.00 | 9.29 | 2 | 77 | 1.5 | 6 | 3 | 2 | 67 | 41 | 13 | 7 | 4 | 0 | 67 |
| 11 | Harold Fannin Jr.Cleveland Browns·#44 | 14 | 20 | 8 | 65 | 1 | 40.0% | 3.25 | 8.12 | 18 | 106 | 1.8 | 2 | 1 | 1 | 58 | 38 | 16 | 5 | 4 | 0 | 58 |
| 12 | Colston LovelandChicago Bears·#84 | 14 | 15 | 7 | 61 | 1 | 46.7% | 4.07 | 8.71 | 2 | 110 | 2.6 | 3 | 2 | 1 | 51 | 30 | 14 | 5 | 2 | 0 | 51 |
| 13 | Dalton KincaidBuffalo Bills·#86 | 12 | 8 | 4 | 57 | 0 | 50.0% | 7.12 | 14.25 | 2 | 75 | 3.5 | 2 | 1 | 0 | 33 | 22 | 8 | 5 | 3 | 0 | 33 |
| 14 | Cole KmetChicago Bears·#85 | 14 | 6 | 3 | 55 | 0 | 50.0% | 9.17 | 18.33 | 12 | 51 | 1.4 | 2 | 1 | 0 | 41 | 20 | 3 | 5 | 2 | 0 | 41 |
| 15 | Mike GesickiCincinnati Bengals·#88 | 12 | 11 | 5 | 51 | 0 | 45.5% | 4.64 | 10.20 | 2 | 100 | 2.3 | 4 | 1 | 0 | 56 | 42 | 11 | 8 | 4 | 0 | 56 |
| 16 | Dalton SchultzHouston Texans·#86 | 14 | 11 | 5 | 48 | 0 | 45.5% | 4.36 | 9.60 | 1 | 68 | 1.6 | 2 | 0 | 0 | 55 | 35 | 10 | 2 | 4 | 0 | 55 |
| 17 | Dawson KnoxBuffalo Bills·#88 | 13 | 9 | 4 | 45 | 1 | 44.4% | 5.00 | 11.25 | 4 | 62 | 2.1 | 4 | 1 | 1 | 35 | 22 | 5 | 3 | 3 | 0 | 35 |
| 18 | Tyler WarrenIndianapolis Colts·#84 | 17 | 17 | 5 | 44 | 0 | 29.4% | 2.59 | 8.80 | 0 | 101 | 1.7 | 6 | 1 | 0 | 81 | 44 | 15 | 15 | 3 | 0 | 81 |
| 19 | David NjokuCleveland Browns·#85 | 11 | 9 | 6 | 43 | 2 | 66.7% | 4.78 | 7.17 | 5 | 50 | 1.3 | 2 | 2 | 2 | 40 | 26 | 8 | 4 | 3 | 0 | 40 |
| 20 | Mason TaylorNew York Jets·#85 | 13 | 14 | 8 | 41 | 0 | 57.1% | 2.93 | 5.12 | 1 | 89 | 1.8 | 5 | 3 | 0 | 57 | 33 | 12 | 3 | 0 | 0 | 57 |
| 21 | Pat FreiermuthPittsburgh Steelers·#88 | 12 | 7 | 3 | 38 | 1 | 42.9% | 5.43 | 12.67 | 5 | 43 | 1.4 | 3 | 1 | 1 | 44 | 21 | 7 | 4 | 2 | 0 | 44 |
| 22 | Evan EngramDenver Broncos·#1 | 15 | 9 | 3 | 37 | 0 | 33.3% | 4.11 | 12.33 | 5 | 59 | 1.5 | 2 | 0 | 0 | 40 | 23 | 7 | 5 | 2 | 0 | 40 |
| 23 | Zach ErtzWashington Commanders·#86 | 11 | 9 | 5 | 35 | 0 | 55.6% | 3.89 | 7.00 | 0 | 108 | 2.4 | 0 | 0 | 0 | 45 | 25 | 8 | 4 | 2 | 0 | 45 |
| 24 | Cade OttonTampa Bay Buccaneers·#88 | 16 | 11 | 4 | 32 | 0 | 36.4% | 2.91 | 8.00 | 8 | 65 | 1.5 | 3 | 0 | 0 | 57 | 33 | 9 | 5 | 1 | 0 | 57 |
| 25 | Daniel BellingerNew York Giants·#82 | 10 | 5 | 2 | 32 | 0 | 40.0% | 6.40 | 16.00 | 2 | 71 | 1.9 | 3 | 2 | 0 | 37 | 20 | 5 | 3 | 2 | 0 | 37 |
| 26 | T.J. HockensonMinnesota Vikings·#87 | 15 | 9 | 4 | 30 | 0 | 44.4% | 3.33 | 7.50 | 0 | 74 | 1.2 | 1 | 0 | 0 | 64 | 37 | 7 | 8 | 2 | 0 | 64 |
| 27 | Gunnar HelmTennessee Titans·#84 | 13 | 8 | 4 | 27 | 0 | 50.0% | 3.38 | 6.75 | 2 | 72 | 2.5 | 2 | 1 | 0 | 30 | 17 | 7 | 2 | 1 | 0 | 30 |
| 28 | Elijah HigginsArizona Cardinals·#84 | 14 | 6 | 2 | 26 | 0 | 33.3% | 4.33 | 13.00 | 11 | 58 | 1.0 | 1 | 0 | 0 | 56 | 28 | 4 | 9 | 1 | 0 | 56 |
| 29 | Jake TongesSan Francisco 49ers·#88 | 10 | 6 | 3 | 24 | 1 | 50.0% | 4.00 | 8.00 | 2 | 50 | 1.4 | 1 | 1 | 1 | 35 | 26 | 5 | 6 | 3 | 0 | 35 |
| 30 | Tyler HigbeeLos Angeles Rams·#89 | 9 | 9 | 3 | 22 | 0 | 33.3% | 2.44 | 7.33 | 9 | 57 | 1.8 | 0 | 0 | 0 | 32 | 20 | 7 | 3 | 1 | 0 | 32 |
| 31 | Chig OkonkwoTennessee Titans·#85 | 16 | 7 | 3 | 19 | 0 | 42.9% | 2.71 | 6.33 | 5 | 21 | 1.4 | 0 | 0 | 0 | 47 | 29 | 5 | 7 | 0 | 0 | 47 |
| 32 | Ja'Tavion SandersCarolina Panthers·#0 | 10 | 6 | 3 | 19 | 0 | 50.0% | 3.17 | 6.33 | 2 | 40 | 1.8 | 3 | 2 | 0 | 32 | 20 | 5 | 2 | 1 | 0 | 32 |
| 33 | Travis KelceKansas City Chiefs·#87 | 14 | 9 | 2 | 19 | 1 | 22.2% | 2.11 | 9.50 | 4 | 90 | 2.4 | 2 | 1 | 1 | 39 | 21 | 9 | 1 | 1 | 0 | 39 |
| 34 | Brenton StrangeJacksonville Jaguars·#85 | 12 | 6 | 2 | 16 | 0 | 33.3% | 2.67 | 8.00 | 3 | 44 | 1.0 | 2 | 0 | 0 | 44 | 26 | 6 | 4 | 1 | 0 | 44 |
| 35 | Jeremy RuckertNew York Jets·#89 | 14 | 6 | 4 | 15 | 1 | 66.7% | 2.50 | 3.75 | 0 | 28 | 0.9 | 3 | 1 | 1 | 32 | 21 | 5 | 3 | 1 | 0 | 32 |
| 36 | Jonnu SmithPittsburgh Steelers·#81 | 14 | 8 | 2 | 13 | 0 | 25.0% | 1.62 | 6.50 | 3 | 73 | 2.5 | 2 | 0 | 0 | 40 | 21 | 8 | 5 | 0 | 0 | 40 |
| 37 | Noah FantCincinnati Bengals·#86 | 13 | 3 | 2 | 12 | 0 | 66.7% | 4.00 | 6.00 | 3 | 16 | 0.4 | 1 | 0 | 0 | 36 | 21 | 3 | 5 | 0 | 0 | 36 |
| 38 | Colby ParkinsonLos Angeles Rams·#84 | 15 | 6 | 2 | 10 | 1 | 33.3% | 1.67 | 5.00 | 0 | 48 | 1.3 | 4 | 1 | 1 | 35 | 19 | 4 | 4 | 2 | 0 | 35 |
| 39 | Tommy TrembleCarolina Panthers·#82 | 12 | 2 | 2 | 7 | 1 | 100.0% | 3.50 | 3.50 | 0 | 7 | 0.3 | 1 | 1 | 1 | 27 | 18 | 1 | 4 | 1 | 0 | 27 |
| 40 | Luke MusgraveGreen Bay Packers·#88 | 11 | 5 | 1 | 6 | 0 | 20.0% | 1.20 | 6.00 | 0 | 27 | 1.0 | 0 | 0 | 0 | 28 | 11 | 3 | 1 | 0 | 0 | 28 |
| 41 | Isaiah LikelyBaltimore Ravens·#80 | 10 | 4 | 2 | 6 | 0 | 50.0% | 1.50 | 3.00 | -2 | 50 | 1.5 | 1 | 0 | 0 | 33 | 18 | 3 | 3 | 0 | 0 | 33 |
| 42 | AJ BarnerSeattle Seahawks·#88 | 15 | 3 | 2 | 6 | 1 | 66.7% | 2.00 | 3.00 | 3 | 7 | 0.2 | 1 | 1 | 1 | 37 | 23 | 3 | 4 | 1 | 0 | 37 |
| 43 | Dallas GoedertPhiladelphia Eagles·#88 | 13 | 4 | 1 | 5 | 0 | 25.0% | 1.25 | 5.00 | 1 | 10 | 0.6 | 0 | 0 | 0 | 45 | 33 | 3 | 9 | 0 | 0 | 45 |
| 44 | Drew SampleCincinnati Bengals·#89 | 14 | 2 | 1 | 5 | 0 | 50.0% | 2.50 | 5.00 | 0 | 4 | 0.1 | 0 | 0 | 0 | 38 | 30 | 1 | 5 | 0 | 0 | 38 |
| 45 | Adam TrautmanDenver Broncos·#82 | 12 | 1 | 1 | 1 | 0 | 100.0% | 1.00 | 1.00 | 0 | 1 | 0.0 | 0 | 0 | 0 | 30 | 17 | 1 | 1 | 0 | 0 | 30 |
| 46 | Charlie WoernerAtlanta Falcons·#89 | 12 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0.0 | 0 | 0 | 0 | 28 | 19 | 0 | 3 | 0 | 0 | 28 |
| 47 | Michael MayerLas Vegas Raiders·#87 | 9 | 4 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 8 | 0.4 | 1 | 0 | 0 | 26 | 8 | 4 | 0 | 0 | 0 | 26 |