| 1 | Jared GoffDetroit Lions·#16 | 13 | 21 | 19 | 90.5% | 164 | 7.81 | 2 | 0 | 0.0% | 0 | 130 | 6.2 | 2.59 | 2.55 | 0 | 0 | 0 | 0 | 0 | 0 | 34 |
| 2 | Joe BurrowCincinnati Bengals·#9 | 7 | 18 | 15 | 83.3% | 190 | 10.56 | 1 | 0 | 0.0% | 1 | 115 | 6.4 | 2.59 | 2.59 | 1 | 2 | 0 | 1 | 1 | 0 | 26 |
| 3 | Bryce YoungCarolina Panthers·#9 | 15 | 29 | 22 | 75.9% | 233 | 8.03 | 0 | 0 | 0.0% | 3 | 139 | 4.8 | 3.00 | 3.00 | 1 | -3 | 0 | 1 | 3 | 1 | 55 |
| 4 | Patrick MahomesKansas City Chiefs·#15 | 12 | 18 | 13 | 72.2% | 257 | 14.28 | 0 | 0 | 0.0% | 3 | 255 | 14.2 | 3.18 | 3.18 | 2 | 11 | 0 | 2 | 0 | 0 | 34 |
| 5 | Joe FlaccoCincinnati Bengals·#16 | 8 | 21 | 15 | 71.4% | 94 | 4.48 | 0 | 0 | 0.0% | 0 | 46 | 2.2 | 2.67 | 2.67 | 0 | 0 | 0 | 0 | 1 | 0 | 26 |
| 6 | Jalen HurtsPhiladelphia Eagles·#1 | 12 | 15 | 10 | 66.7% | 123 | 8.20 | 1 | 1 | 6.7% | 0 | 97 | 6.5 | 2.86 | 2.86 | 0 | 0 | 0 | 0 | 1 | 0 | 39 |
| 7 | Geno SmithLas Vegas Raiders·#7 | 14 | 39 | 26 | 66.7% | 305 | 7.82 | 4 | 1 | 2.6% | 3 | 315 | 8.1 | 2.73 | 2.71 | 3 | 33 | 0 | 2 | 0 | 0 | 67 |
| 8 | Sam DarnoldSeattle Seahawks·#14 | 16 | 26 | 17 | 65.4% | 168 | 6.46 | 1 | 2 | 7.7% | 6 | 186 | 6.6 | 2.80 | 2.84 | 1 | 12 | 0 | 2 | 1 | 0 | 50 |
| 9 | Jacoby BrissettArizona Cardinals·#7 | 10 | 14 | 9 | 64.3% | 65 | 4.64 | 1 | 0 | 0.0% | 1 | 8 | 0.6 | 2.66 | 2.66 | 1 | -4 | 0 | 0 | 3 | 1 | 31 |
| 10 | Trevor LawrenceJacksonville Jaguars·#16 | 17 | 32 | 20 | 62.5% | 261 | 8.16 | 3 | 0 | 0.0% | 4 | 338 | 10.6 | 2.87 | 2.87 | 0 | 0 | 0 | 1 | 0 | 0 | 55 |
| 11 | Bo NixDenver Broncos·#10 | 14 | 20 | 12 | 60.0% | 180 | 9.00 | 1 | 0 | 0.0% | 4 | 196 | 9.8 | 3.24 | 3.24 | 2 | 10 | 0 | 0 | 2 | 0 | 32 |
| 12 | Matthew StaffordLos Angeles Rams·#9 | 15 | 40 | 23 | 57.5% | 290 | 7.25 | 1 | 0 | 0.0% | 4 | 425 | 10.9 | 3.17 | 3.17 | 1 | 0 | 0 | 0 | 1 | 0 | 59 |
| 13 | C.J. StroudHouston Texans·#7 | 13 | 23 | 13 | 56.5% | 152 | 6.61 | 1 | 0 | 0.0% | 3 | 265 | 11.5 | 2.54 | 2.54 | 2 | 9 | 0 | 1 | 2 | 0 | 36 |
| 14 | Cam WardTennessee Titans·#1 | 11 | 16 | 9 | 56.3% | 73 | 4.56 | 0 | 0 | 0.0% | 0 | 101 | 6.3 | 3.33 | 3.33 | 0 | 0 | 0 | 0 | 1 | 1 | 25 |
| 15 | Aaron RodgersPittsburgh Steelers·#8 | 14 | 19 | 10 | 52.6% | 94 | 4.95 | 0 | 1 | 5.3% | 2 | 113 | 6.0 | 2.40 | 2.40 | 1 | 0 | 0 | 1 | 1 | 0 | 27 |
| 16 | Jordan LoveGreen Bay Packers·#10 | 10 | 15 | 7 | 46.7% | 37 | 2.47 | 1 | 0 | 0.0% | 0 | 99 | 6.6 | 2.84 | 2.84 | 1 | 10 | 0 | 0 | 1 | 0 | 27 |
| 17 | Baker MayfieldTampa Bay Buccaneers·#6 | 14 | 9 | 4 | 44.4% | 72 | 8.00 | 0 | 0 | 0.0% | 1 | 112 | 12.4 | 2.98 | 2.98 | 3 | 27 | 0 | 1 | 0 | 0 | 27 |
| 18 | Michael Penix Jr.Atlanta Falcons·#9 | 8 | 25 | 11 | 44.0% | 173 | 6.92 | 0 | 1 | 4.0% | 3 | 311 | 12.4 | 3.03 | 3.03 | 2 | 6 | 0 | 0 | 0 | 0 | 37 |
| 19 | Caleb WilliamsChicago Bears·#18 | 14 | 19 | 8 | 42.1% | 87 | 4.58 | 0 | 1 | 5.3% | 2 | 184 | 9.7 | 3.55 | 3.55 | 3 | 20 | 0 | 0 | 1 | 1 | 43 |
| 20 | Dak PrescottDallas Cowboys·#4 | 15 | 7 | 2 | 28.6% | -2 | -0.29 | 0 | 0 | 0.0% | 3 | 25 | 3.6 | 2.97 | 2.97 | 0 | 0 | 0 | 0 | 1 | 0 | 50 |