| 1 | Aaron JonesMinnesota Vikings·#33 | 11 | 50 | 221 | 4.42 | 2 | 135 | 15 | 3 | 17 | 12 | 56 | 0 | 70.6% | 3.29 | 4.67 | 65 | 3 | 2 | 0 | 0 | 120 |
| 2 | Ashton JeantyLas Vegas Raiders·#2 | 15 | 62 | 203 | 3.27 | 1 | 157 | 9 | 3 | 18 | 14 | 74 | 0 | 77.8% | 4.11 | 5.29 | 100 | 3 | 2 | 0 | 0 | 173 |
| 3 | Audric EstiméNew Orleans Saints·#30 | 5 | 3 | 2 | 0.67 | 0 | 15 | 0 | 0 | 5 | 5 | 36 | 0 | 100.0% | 7.20 | 7.20 | 48 | 0 | 0 | 0 | 0 | 26 |
| 4 | Bam KnightArizona Cardinals·#20 | 6 | 23 | 96 | 4.17 | 0 | 60 | 4 | 0 | 2 | 1 | 5 | 0 | 50.0% | 2.50 | 5.00 | 5 | 1 | 1 | 0 | 0 | 64 |
| 5 | Blake CorumLos Angeles Rams·#22 | 6 | 15 | 51 | 3.40 | 0 | 23 | 4 | 3 | 3 | 1 | 13 | 0 | 33.3% | 4.33 | 13.00 | 7 | 0 | 0 | 0 | 0 | 31 |
| 6 | Bhayshul TutenJacksonville Jaguars·#33 | 8 | 16 | 65 | 4.06 | 1 | 38 | 3 | 2 | 4 | 2 | 5 | 1 | 50.0% | 1.25 | 2.50 | 16 | 1 | 1 | 1 | 0 | 36 |
| 7 | Breece HallNew York Jets·#20 | 11 | 65 | 247 | 3.80 | 1 | 94 | 16 | 2 | 8 | 6 | 82 | 1 | 75.0% | 10.25 | 13.67 | 85 | 2 | 0 | 0 | 0 | 129 |
| 8 | Brashard SmithKansas City Chiefs·#24 | 11 | 12 | 54 | 4.50 | 0 | 31 | 3 | 0 | 6 | 3 | 32 | 0 | 50.0% | 5.33 | 10.67 | 39 | 0 | 0 | 0 | 0 | 33 |
| 9 | Cam SkatteboNew York Giants·#44 | 5 | 12 | 53 | 4.42 | 0 | 33 | 5 | 0 | 3 | 2 | 12 | 0 | 66.7% | 4.00 | 6.00 | 16 | 0 | 0 | 0 | 0 | 31 |
| 10 | Chase BrownCincinnati Bengals·#30 | 13 | 49 | 209 | 4.27 | 2 | 139 | 11 | 3 | 8 | 7 | 31 | 1 | 87.5% | 3.88 | 4.43 | 34 | 1 | 1 | 1 | 0 | 112 |
| 11 | Brian RobinsonSan Francisco 49ers·#3 | 10 | 17 | 106 | 6.24 | 0 | 63 | 6 | 1 | 4 | 2 | 10 | 0 | 50.0% | 2.50 | 5.00 | 21 | 1 | 1 | 0 | 0 | 34 |
| 12 | Bucky IrvingTampa Bay Buccaneers·#7 | 8 | 38 | 125 | 3.29 | 0 | 80 | 7 | 0 | 6 | 5 | 25 | 1 | 83.3% | 4.17 | 5.00 | 39 | 1 | 1 | 1 | 0 | 79 |
| 13 | Chris BrooksGreen Bay Packers·#30 | 11 | 1 | 1 | 1.00 | 0 | 1 | 0 | 0 | 1 | 1 | 16 | 0 | 100.0% | 16.00 | 16.00 | 21 | 0 | 0 | 0 | 0 | 26 |
| 14 | Chris Rodriguez Jr.Washington Commanders·#36 | 7 | 23 | 113 | 4.91 | 0 | 63 | 6 | 4 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 20 | 0 | 0 | 0 | 0 | 38 |
| 15 | Dare OgunbowaleHouston Texans·#33 | 10 | 2 | 12 | 6.00 | 1 | 14 | 1 | 1 | 2 | 2 | 11 | 0 | 100.0% | 5.50 | 5.50 | 10 | 0 | 0 | 0 | 0 | 27 |
| 16 | Christian McCaffreySan Francisco 49ers·#23 | 15 | 80 | 352 | 4.40 | 3 | 236 | 23 | 7 | 31 | 25 | 195 | 1 | 80.7% | 6.29 | 7.80 | 146 | 4 | 2 | 1 | 0 | 219 |
| 17 | Jahmyr GibbsDetroit Lions·#0 | 15 | 61 | 290 | 4.75 | 5 | 138 | 15 | 6 | 22 | 18 | 157 | 1 | 81.8% | 7.14 | 8.72 | 154 | 4 | 3 | 1 | 0 | 156 |
| 18 | Jacory Croskey-MerrittWashington Commanders·#22 | 5 | 19 | 60 | 3.16 | 1 | 12 | 4 | 3 | 2 | 2 | 39 | 0 | 100.0% | 19.50 | 19.50 | 37 | 1 | 1 | 0 | 0 | 41 |
| 19 | Derrick HenryBaltimore Ravens·#22 | 12 | 67 | 328 | 4.90 | 3 | 170 | 18 | 6 | 3 | 3 | 25 | 0 | 100.0% | 8.33 | 8.33 | 22 | 0 | 0 | 0 | 0 | 112 |
| 20 | De'Von AchaneMiami Dolphins·#28 | 14 | 56 | 378 | 6.75 | 1 | 138 | 15 | 2 | 15 | 13 | 97 | 1 | 86.7% | 6.47 | 7.46 | 93 | 1 | 1 | 1 | 0 | 121 |
| 21 | Devin NealNew Orleans Saints·#24 | 4 | 6 | 16 | 2.67 | 1 | 11 | 1 | 1 | 3 | 3 | 24 | 0 | 100.0% | 8.00 | 8.00 | 27 | 0 | 0 | 0 | 0 | 27 |
| 22 | Isaiah DavisNew York Jets·#32 | 11 | 9 | 28 | 3.11 | 0 | 15 | 1 | 0 | 5 | 3 | 10 | 0 | 60.0% | 2.00 | 3.33 | 16 | 0 | 0 | 0 | 0 | 39 |
| 23 | Emanuel WilsonGreen Bay Packers·#23 | 9 | 10 | 33 | 3.30 | 0 | 22 | 2 | 1 | 2 | 1 | 1 | 0 | 50.0% | 0.50 | 1.00 | 7 | 0 | 0 | 0 | 0 | 44 |
| 24 | Devin SingletaryNew York Giants·#26 | 9 | 13 | 73 | 5.62 | 2 | 33 | 5 | 2 | 3 | 3 | 5 | 0 | 100.0% | 1.67 | 1.67 | 20 | 0 | 0 | 0 | 0 | 35 |
| 25 | Isiah PachecoKansas City Chiefs·#10 | 10 | 27 | 106 | 3.93 | 0 | 71 | 7 | 0 | 5 | 5 | 20 | 0 | 100.0% | 4.00 | 4.00 | 38 | 0 | 0 | 0 | 0 | 87 |
| 26 | Kareem HuntKansas City Chiefs·#29 | 14 | 31 | 124 | 4.00 | 1 | 61 | 10 | 3 | 4 | 3 | 10 | 1 | 75.0% | 2.50 | 3.33 | 5 | 1 | 1 | 1 | 0 | 100 |
| 27 | Keaton MitchellBaltimore Ravens·#34 | 8 | 11 | 49 | 4.45 | 0 | 35 | 3 | 0 | 3 | 3 | 16 | 0 | 100.0% | 5.33 | 5.33 | 22 | 0 | 0 | 0 | 0 | 26 |
| 28 | Kenneth GainwellPittsburgh Steelers·#14 | 13 | 11 | 71 | 6.45 | 1 | 27 | 2 | 2 | 10 | 8 | 64 | 1 | 80.0% | 6.40 | 8.00 | 81 | 1 | 1 | 1 | 0 | 50 |
| 29 | Jeremy McNicholsWashington Commanders·#26 | 8 | 8 | 70 | 8.75 | 1 | 85 | 1 | 1 | 2 | 2 | 32 | 0 | 100.0% | 16.00 | 16.00 | 22 | 0 | 0 | 0 | 0 | 39 |
| 30 | Jerome FordCleveland Browns·#34 | 8 | 5 | 7 | 1.40 | 0 | 8 | 1 | 1 | 3 | 3 | 32 | 0 | 100.0% | 10.67 | 10.67 | 45 | 0 | 0 | 0 | 0 | 34 |
| 31 | Jonathan TaylorIndianapolis Colts·#28 | 15 | 61 | 280 | 4.59 | 3 | 202 | 17 | 5 | 10 | 9 | 76 | 0 | 90.0% | 7.60 | 8.44 | 82 | 0 | 0 | 0 | 0 | 157 |
| 32 | James ConnerArizona Cardinals·#6 | 2 | 13 | 36 | 2.77 | 0 | 48 | 3 | 0 | 6 | 5 | 16 | 1 | 83.3% | 2.67 | 3.20 | 38 | 1 | 1 | 1 | 0 | 38 |
| 33 | Tank BigsbyPhiladelphia Eagles·#37 | 6 | 11 | 61 | 5.55 | 0 | 47 | 3 | 0 | 1 | 1 | 31 | 0 | 100.0% | 31.00 | 31.00 | 30 | 0 | 0 | 0 | 0 | 33 |
| 34 | Sean TuckerTampa Bay Buccaneers·#44 | 9 | 18 | 67 | 3.72 | 1 | 50 | 8 | 3 | 3 | 2 | -1 | 0 | 66.7% | -0.33 | -0.50 | 8 | 2 | 1 | 0 | 0 | 40 |
| 35 | Samaje PerineCincinnati Bengals·#34 | 12 | 13 | 48 | 3.69 | 0 | 38 | 5 | 0 | 7 | 6 | 30 | 0 | 85.7% | 4.29 | 5.00 | 36 | 0 | 0 | 0 | 0 | 47 |
| 36 | Rachaad WhiteTampa Bay Buccaneers·#1 | 13 | 37 | 136 | 3.68 | 2 | 103 | 14 | 6 | 7 | 6 | 27 | 0 | 85.7% | 3.86 | 4.50 | 42 | 1 | 1 | 0 | 0 | 103 |
| 37 | Omarion HamptonLos Angeles Chargers·#8 | 7 | 18 | 89 | 4.94 | 0 | 43 | 5 | 0 | 3 | 2 | 12 | 1 | 66.7% | 4.00 | 6.00 | 17 | 1 | 1 | 1 | 0 | 51 |
| 38 | Michael CarterArizona Cardinals·#22 | 7 | 14 | 26 | 1.86 | 1 | 22 | 2 | 1 | 4 | 2 | 10 | 0 | 50.0% | 2.50 | 5.00 | 8 | 0 | 0 | 0 | 0 | 38 |
| 39 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 14 | 4 | 14 | 3.50 | 0 | 16 | 2 | 0 | 2 | 2 | 9 | 0 | 100.0% | 4.50 | 4.50 | 18 | 0 | 0 | 0 | 0 | 44 |
| 40 | Justice HillBaltimore Ravens·#43 | 5 | 4 | 17 | 4.25 | 0 | 9 | 2 | 0 | 3 | 2 | 15 | 1 | 66.7% | 5.00 | 7.50 | 12 | 1 | 1 | 1 | 0 | 25 |
| 41 | Kimani VidalLos Angeles Chargers·#30 | 9 | 25 | 99 | 3.96 | 1 | 74 | 4 | 0 | 3 | 3 | 77 | 0 | 100.0% | 25.67 | 25.67 | 83 | 0 | 0 | 0 | 0 | 73 |
| 42 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 54 | 195 | 3.61 | 0 | 105 | 8 | 1 | 10 | 10 | 133 | 0 | 100.0% | 13.30 | 13.30 | 159 | 0 | 0 | 0 | 0 | 113 |
| 43 | Kyle MonangaiChicago Bears·#25 | 14 | 26 | 128 | 4.92 | 1 | 60 | 8 | 2 | 8 | 4 | 24 | 0 | 50.0% | 3.00 | 6.00 | 15 | 2 | 1 | 0 | 0 | 69 |
| 44 | Quinshon JudkinsCleveland Browns·#10 | 11 | 55 | 231 | 4.20 | 3 | 128 | 13 | 3 | 9 | 5 | 18 | 0 | 55.6% | 2.00 | 3.60 | 23 | 0 | 0 | 0 | 0 | 107 |
| 45 | Ollie Gordon IIMiami Dolphins·#31 | 12 | 16 | 48 | 3.00 | 1 | 15 | 6 | 3 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 35 |
| 46 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 56 | 265 | 4.73 | 4 | 165 | 17 | 7 | 18 | 11 | 86 | 0 | 61.1% | 4.78 | 7.82 | 38 | 4 | 2 | 0 | 0 | 178 |
| 47 | TreVeyon HendersonNew England Patriots·#32 | 14 | 26 | 123 | 4.73 | 2 | 52 | 7 | 1 | 8 | 8 | 56 | 0 | 100.0% | 7.00 | 7.00 | 50 | 1 | 1 | 0 | 0 | 78 |
| 48 | Travis EtienneJacksonville Jaguars·#1 | 16 | 75 | 317 | 4.23 | 2 | 196 | 15 | 4 | 12 | 9 | 55 | 2 | 75.0% | 4.58 | 6.11 | 80 | 3 | 3 | 2 | 0 | 185 |
| 49 | Will ShipleyPhiladelphia Eagles·#28 | 6 | 5 | 17 | 3.40 | 0 | 2 | 1 | 0 | 2 | 1 | 11 | 0 | 50.0% | 5.50 | 11.00 | 2 | 1 | 0 | 0 | 0 | 27 |
| 50 | Woody MarksHouston Texans·#27 | 15 | 40 | 119 | 2.98 | 0 | 85 | 4 | 1 | 3 | 1 | 37 | 0 | 33.3% | 12.33 | 37.00 | 32 | 0 | 0 | 0 | 0 | 99 |