| 1 | AJ DillonPhiladelphia Eagles·#29 | 6 | 9 | 44 | 4.89 | 0 | 29 | 1 | 0 | 2 | 2 | 18 | 0 | 100.0% | 9.00 | 9.00 | 9 | 0 | 0 | 0 | 1 | 29 |
| 2 | Aaron JonesMinnesota Vikings·#33 | 12 | 104 | 441 | 4.24 | 0 | 276 | 12 | 0 | 31 | 22 | 180 | 1 | 71.0% | 5.81 | 8.18 | 193 | 3 | 2 | 0 | 2 | 266 |
| 3 | Alvin KamaraNew Orleans Saints·#41 | 11 | 91 | 320 | 3.52 | 0 | 247 | 5 | 0 | 33 | 28 | 180 | 0 | 84.8% | 5.45 | 6.43 | 181 | 5 | 4 | 0 | 4 | 311 |
| 4 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 9 | 33 | 3.67 | 0 | 22 | 0 | 0 | 14 | 13 | 89 | 0 | 92.9% | 6.36 | 6.85 | 87 | 1 | 1 | 0 | 0 | 55 |
| 5 | Antonio GibsonNew England Patriots·#4 | 5 | 19 | 76 | 4.00 | 0 | 41 | 2 | 0 | 3 | 2 | 6 | 0 | 66.7% | 2.00 | 3.00 | 16 | 0 | 0 | 0 | 1 | 34 |
| 6 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 195 | 765 | 3.92 | 2 | 595 | 18 | 0 | 60 | 45 | 240 | 2 | 75.0% | 4.00 | 5.33 | 369 | 7 | 7 | 2 | 0 | 524 |
| 7 | Audric EstiméNew Orleans Saints·#30 | 5 | 28 | 140 | 5.00 | 1 | 152 | 2 | 0 | 11 | 10 | 79 | 0 | 90.9% | 7.18 | 7.90 | 100 | 0 | 0 | 0 | 1 | 115 |
| 8 | Austin EkelerWashington Commanders·#30 | 2 | 9 | 35 | 3.89 | 0 | 29 | 0 | 0 | 5 | 4 | 26 | 0 | 80.0% | 5.20 | 6.50 | 41 | 0 | 0 | 0 | 0 | 43 |
| 9 | Bam KnightArizona Cardinals·#20 | 10 | 52 | 184 | 3.54 | 0 | 141 | 4 | 0 | 25 | 17 | 126 | 0 | 68.0% | 5.04 | 7.41 | 131 | 2 | 1 | 0 | 3 | 192 |
| 10 | Bhayshul TutenJacksonville Jaguars·#33 | 15 | 49 | 202 | 4.12 | 0 | 139 | 4 | 0 | 14 | 10 | 79 | 2 | 71.4% | 5.64 | 7.90 | 80 | 2 | 2 | 2 | 1 | 129 |
| 11 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 208 | 1,140 | 5.48 | 2 | 841 | 28 | 0 | 80 | 61 | 633 | 1 | 76.3% | 7.91 | 10.38 | 673 | 7 | 5 | 1 | 5 | 594 |
| 12 | Blake CorumLos Angeles Rams·#22 | 17 | 97 | 557 | 5.74 | 2 | 252 | 18 | 0 | 12 | 7 | 23 | 0 | 58.3% | 1.92 | 3.29 | 30 | 1 | 0 | 0 | 1 | 204 |
| 13 | Braelon AllenNew York Jets·#0 | 4 | 10 | 38 | 3.80 | 1 | 15 | 1 | 0 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 9 | 1 | 1 | 0 | 0 | 30 |
| 14 | Brashard SmithKansas City Chiefs·#24 | 17 | 34 | 108 | 3.18 | 0 | 103 | 2 | 0 | 26 | 20 | 174 | 0 | 76.9% | 6.69 | 8.70 | 213 | 4 | 3 | 0 | 1 | 116 |
| 15 | Breece HallNew York Jets·#20 | 16 | 166 | 824 | 4.96 | 2 | 381 | 22 | 0 | 38 | 31 | 313 | 1 | 81.6% | 8.24 | 10.10 | 304 | 6 | 1 | 0 | 2 | 417 |
| 16 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 64 | 312 | 4.88 | 1 | 149 | 8 | 0 | 10 | 6 | 17 | 0 | 60.0% | 1.70 | 2.83 | 23 | 2 | 1 | 0 | 0 | 119 |
| 17 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 127 | 456 | 3.59 | 0 | 282 | 8 | 0 | 28 | 24 | 255 | 3 | 85.7% | 9.11 | 10.62 | 313 | 4 | 3 | 1 | 0 | 301 |
| 18 | Cam SkatteboNew York Giants·#44 | 8 | 63 | 311 | 4.94 | 1 | 232 | 9 | 0 | 23 | 18 | 174 | 2 | 78.3% | 7.57 | 9.67 | 175 | 3 | 3 | 2 | 2 | 168 |
| 19 | Chase BrownCincinnati Bengals·#30 | 17 | 168 | 794 | 4.73 | 1 | 560 | 21 | 0 | 66 | 56 | 343 | 3 | 84.8% | 5.20 | 6.12 | 340 | 7 | 6 | 3 | 3 | 515 |
| 20 | Chris BrooksGreen Bay Packers·#30 | 17 | 22 | 95 | 4.32 | 0 | 69 | 3 | 0 | 14 | 10 | 76 | 0 | 71.4% | 5.43 | 7.60 | 95 | 2 | 0 | 0 | 0 | 126 |
| 21 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 67 | 344 | 5.13 | 1 | 226 | 9 | 0 | 3 | 3 | 30 | 0 | 100.0% | 10.00 | 10.00 | 26 | 0 | 0 | 0 | 1 | 157 |
| 22 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 205 | 800 | 3.90 | 0 | 570 | 20 | 0 | 98 | 79 | 716 | 3 | 80.6% | 7.31 | 9.06 | 557 | 14 | 11 | 3 | 6 | 615 |
| 23 | Chuba HubbardCarolina Panthers·#30 | 15 | 86 | 371 | 4.31 | 0 | 236 | 5 | 0 | 26 | 19 | 167 | 2 | 73.1% | 6.42 | 8.79 | 204 | 2 | 1 | 0 | 3 | 265 |
| 24 | D'Andre SwiftChicago Bears·#4 | 16 | 148 | 759 | 5.13 | 3 | 437 | 21 | 0 | 36 | 27 | 181 | 0 | 75.0% | 5.03 | 6.70 | 238 | 1 | 1 | 0 | 3 | 413 |
| 25 | DJ GiddensIndianapolis Colts·#21 | 6 | 17 | 62 | 3.65 | 0 | 39 | 1 | 0 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 1 | 36 |
| 26 | Dare OgunbowaleHouston Texans·#33 | 14 | 5 | 20 | 4.00 | 0 | 17 | 0 | 0 | 10 | 8 | 66 | 0 | 80.0% | 6.60 | 8.25 | 51 | 2 | 1 | 0 | 1 | 76 |
| 27 | David MontgomeryDetroit Lions·#5 | 17 | 107 | 577 | 5.39 | 3 | 350 | 17 | 0 | 27 | 22 | 179 | 0 | 81.5% | 6.63 | 8.14 | 191 | 2 | 1 | 0 | 3 | 270 |
| 28 | De'Von AchaneMiami Dolphins·#28 | 16 | 185 | 1,132 | 6.12 | 7 | 710 | 33 | 0 | 66 | 53 | 374 | 2 | 80.3% | 5.67 | 7.06 | 467 | 8 | 5 | 2 | 2 | 494 |
| 29 | Derrick HenryBaltimore Ravens·#22 | 17 | 195 | 1,159 | 5.94 | 5 | 649 | 31 | 0 | 19 | 15 | 150 | 0 | 79.0% | 7.89 | 10.00 | 135 | 2 | 2 | 0 | 3 | 373 |
| 30 | Devin NealNew Orleans Saints·#24 | 9 | 36 | 146 | 4.06 | 0 | 81 | 3 | 0 | 17 | 16 | 94 | 0 | 94.1% | 5.53 | 5.88 | 131 | 1 | 1 | 0 | 0 | 168 |
| 31 | Devin SingletaryNew York Giants·#26 | 17 | 70 | 247 | 3.53 | 0 | 167 | 4 | 0 | 14 | 13 | 85 | 0 | 92.9% | 6.07 | 6.54 | 90 | 0 | 0 | 0 | 1 | 176 |
| 32 | Dylan SampsonCleveland Browns·#22 | 15 | 50 | 142 | 2.84 | 0 | 185 | 3 | 0 | 34 | 28 | 214 | 2 | 82.3% | 6.29 | 7.64 | 256 | 6 | 4 | 1 | 2 | 186 |
| 33 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 81 | 330 | 4.07 | 1 | 267 | 9 | 0 | 13 | 12 | 97 | 0 | 92.3% | 7.46 | 8.08 | 122 | 1 | 1 | 0 | 0 | 212 |
| 34 | Emari DemercadoArizona Cardinals·#31 | 11 | 34 | 139 | 4.09 | 0 | 77 | 3 | 0 | 17 | 12 | 99 | 1 | 70.6% | 5.82 | 8.25 | 84 | 2 | 2 | 1 | 2 | 129 |
| 35 | Evan HullNew Orleans Saints·#34 | 6 | 14 | 34 | 2.43 | 0 | 13 | 0 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 1 | 53 |
| 36 | George HolaniSeattle Seahawks·#36 | 4 | 15 | 56 | 3.73 | 1 | 37 | 1 | 0 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 16 | 0 | 0 | 0 | 1 | 27 |
| 37 | Hassan HaskinsLos Angeles Chargers·#28 | 9 | 12 | 34 | 2.83 | 0 | 21 | 1 | 0 | 3 | 3 | 11 | 0 | 100.0% | 3.67 | 3.67 | 11 | 0 | 0 | 0 | 2 | 51 |
| 38 | Isaiah DavisNew York Jets·#32 | 16 | 28 | 185 | 6.61 | 0 | 145 | 4 | 0 | 26 | 20 | 180 | 0 | 76.9% | 6.92 | 9.00 | 183 | 1 | 1 | 0 | 1 | 190 |
| 39 | Isiah PachecoKansas City Chiefs·#10 | 13 | 84 | 337 | 4.01 | 0 | 220 | 8 | 0 | 18 | 14 | 59 | 1 | 77.8% | 3.28 | 4.21 | 87 | 1 | 1 | 1 | 0 | 298 |
| 40 | J.K. DobbinsDenver Broncos·#27 | 10 | 104 | 597 | 5.74 | 1 | 320 | 16 | 0 | 13 | 11 | 42 | 0 | 84.6% | 3.23 | 3.82 | 56 | 0 | 0 | 0 | 1 | 226 |
| 41 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 117 | 593 | 5.07 | 2 | 387 | 13 | 0 | 10 | 7 | 64 | 0 | 70.0% | 6.40 | 9.14 | 62 | 1 | 1 | 0 | 2 | 272 |
| 42 | Jahmyr GibbsDetroit Lions·#0 | 17 | 167 | 785 | 4.70 | 5 | 413 | 19 | 0 | 77 | 63 | 483 | 2 | 81.8% | 6.27 | 7.67 | 480 | 10 | 8 | 2 | 2 | 500 |
| 43 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 26 | 135 | 5.19 | 0 | 56 | 3 | 0 | 4 | 3 | 18 | 0 | 75.0% | 4.50 | 6.00 | 31 | 0 | 0 | 0 | 0 | 53 |
| 44 | James ConnerArizona Cardinals·#6 | 3 | 19 | 70 | 3.68 | 0 | 65 | 0 | 0 | 7 | 6 | 29 | 0 | 85.7% | 4.14 | 4.83 | 55 | 0 | 0 | 0 | 0 | 61 |
| 45 | James CookBuffalo Bills·#4 | 17 | 224 | 1,145 | 5.11 | 2 | 623 | 31 | 0 | 33 | 28 | 174 | 1 | 84.8% | 5.27 | 6.21 | 153 | 2 | 2 | 0 | 3 | 431 |
| 46 | Jaret PattersonLos Angeles Chargers·#32 | 6 | 31 | 136 | 4.39 | 0 | 81 | 3 | 0 | 3 | 2 | 4 | 0 | 66.7% | 1.33 | 2.00 | 5 | 0 | 0 | 0 | 1 | 79 |
| 47 | Javonte WilliamsDallas Cowboys·#33 | 16 | 169 | 927 | 5.49 | 1 | 582 | 21 | 0 | 35 | 28 | 114 | 0 | 80.0% | 3.26 | 4.07 | 174 | 6 | 4 | 0 | 3 | 475 |
| 48 | Jawhar JordanHouston Texans·#26 | 4 | 35 | 173 | 4.94 | 0 | 106 | 6 | 0 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 40 | 0 | 0 | 0 | 0 | 60 |
| 49 | Jaydon BlueDallas Cowboys·#23 | 5 | 34 | 112 | 3.29 | 1 | 39 | 6 | 0 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 10 | 0 | 0 | 0 | 0 | 60 |
| 50 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 136 | 702 | 5.16 | 1 | 511 | 17 | 0 | 36 | 32 | 259 | 0 | 88.9% | 7.19 | 8.09 | 368 | 4 | 3 | 0 | 3 | 330 |