| 1 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 33 | 124 | 3.76 | 1 | 105 | 6 | 7 | 3 | 2 | 49 | 1 | 66.7% | 16.33 | 24.50 | 24 | 0 | 0 | 0 | 0 | 99 |
| 2 | Derrick HenryBaltimore Ravens·#22 | 16 | 52 | 266 | 5.12 | 0 | 171 | 16 | 6 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 74 |
| 3 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 45 | 193 | 4.29 | 3 | 115 | 19 | 6 | 20 | 15 | 113 | 1 | 75.0% | 5.65 | 7.53 | 91 | 5 | 5 | 1 | 0 | 134 |
| 4 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 30 | 160 | 5.33 | 5 | 110 | 16 | 6 | 4 | 3 | 32 | 0 | 75.0% | 8.00 | 10.67 | 24 | 0 | 0 | 0 | 0 | 65 |
| 5 | Josh JacobsGreen Bay Packers·#8 | 14 | 29 | 119 | 4.10 | 0 | 85 | 9 | 5 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 1 | 67 |
| 6 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 20 | 47 | 2.35 | 2 | 64 | 5 | 5 | 5 | 5 | 62 | 1 | 100.0% | 12.40 | 12.40 | 73 | 1 | 1 | 1 | 0 | 63 |
| 7 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 37 | 152 | 4.11 | 1 | 77 | 13 | 5 | 9 | 4 | 28 | 0 | 44.4% | 3.11 | 7.00 | 16 | 4 | 2 | 0 | 0 | 116 |
| 8 | Chris Rodriguez Jr.Washington Commanders·#36 | 11 | 19 | 84 | 4.42 | 1 | 45 | 6 | 5 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 0 | 34 |
| 9 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 26 | 93 | 3.58 | 3 | 46 | 7 | 5 | 2 | 1 | 5 | 0 | 50.0% | 2.50 | 5.00 | 9 | 0 | 0 | 0 | 0 | 59 |
| 10 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 49 | 249 | 5.08 | 4 | 157 | 18 | 5 | 2 | 2 | 10 | 0 | 100.0% | 5.00 | 5.00 | 20 | 0 | 0 | 0 | 2 | 116 |
| 11 | Jahmyr GibbsDetroit Lions·#0 | 17 | 36 | 216 | 6.00 | 4 | 136 | 11 | 5 | 8 | 8 | 100 | 1 | 100.0% | 12.50 | 12.50 | 108 | 2 | 2 | 1 | 1 | 110 |
| 12 | James CookBuffalo Bills·#4 | 16 | 41 | 239 | 5.83 | 1 | 192 | 10 | 4 | 4 | 2 | 56 | 1 | 50.0% | 14.00 | 28.00 | 58 | 1 | 1 | 1 | 0 | 87 |
| 13 | Rhamondre StevensonNew England Patriots·#38 | 14 | 21 | 114 | 5.43 | 3 | 74 | 9 | 4 | 5 | 4 | 23 | 0 | 80.0% | 4.60 | 5.75 | 18 | 2 | 2 | 0 | 0 | 76 |
| 14 | RJ HarveyDenver Broncos·#12 | 15 | 22 | 48 | 2.18 | 2 | 42 | 4 | 4 | 7 | 5 | 50 | 2 | 71.4% | 7.14 | 10.00 | 55 | 3 | 3 | 2 | 0 | 59 |
| 15 | Javonte WilliamsDallas Cowboys·#33 | 16 | 29 | 119 | 4.10 | 2 | 54 | 14 | 4 | 6 | 3 | 10 | 0 | 50.0% | 1.67 | 3.33 | 20 | 3 | 2 | 0 | 0 | 113 |
| 16 | Jaylen WarrenPittsburgh Steelers·#30 | 15 | 26 | 111 | 4.27 | 1 | 103 | 4 | 4 | 8 | 7 | 68 | 2 | 87.5% | 8.50 | 9.71 | 71 | 1 | 1 | 1 | 0 | 64 |
| 17 | De'Von AchaneMiami Dolphins·#28 | 16 | 30 | 140 | 4.67 | 1 | 41 | 11 | 4 | 13 | 10 | 82 | 1 | 76.9% | 6.31 | 8.20 | 67 | 1 | 1 | 0 | 1 | 93 |
| 18 | Chase BrownCincinnati Bengals·#30 | 17 | 29 | 112 | 3.86 | 2 | 82 | 8 | 4 | 12 | 7 | 51 | 1 | 58.3% | 4.25 | 7.29 | 43 | 2 | 1 | 1 | 1 | 88 |
| 19 | Blake CorumLos Angeles Rams·#22 | 15 | 21 | 95 | 4.52 | 0 | 50 | 8 | 4 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0 | 0 | 0 | 53 |
| 20 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 31 | 177 | 5.71 | 3 | 132 | 7 | 4 | 13 | 9 | 91 | 2 | 69.2% | 7.00 | 10.11 | 88 | 3 | 1 | 1 | 0 | 117 |
| 21 | D'Andre SwiftChicago Bears·#4 | 16 | 39 | 211 | 5.41 | 1 | 91 | 18 | 4 | 7 | 5 | 94 | 1 | 71.4% | 13.43 | 18.80 | 93 | 0 | 0 | 0 | 0 | 98 |
| 22 | Tyler AllgeierAtlanta Falcons·#25 | 16 | 20 | 61 | 3.05 | 2 | 38 | 7 | 4 | 1 | 1 | 15 | 0 | 100.0% | 15.00 | 15.00 | 15 | 0 | 0 | 0 | 0 | 46 |
| 23 | TreVeyon HendersonNew England Patriots·#32 | 15 | 28 | 89 | 3.18 | 2 | 49 | 9 | 4 | 8 | 6 | 29 | 1 | 75.0% | 3.62 | 4.83 | 26 | 3 | 3 | 1 | 0 | 64 |
| 24 | Jordan MasonMinnesota Vikings·#27 | 15 | 19 | 72 | 3.79 | 2 | 47 | 8 | 3 | 1 | 1 | 2 | 0 | 100.0% | 2.00 | 2.00 | 7 | 0 | 0 | 0 | 2 | 53 |
| 25 | Travis EtienneJacksonville Jaguars·#1 | 16 | 35 | 129 | 3.69 | 1 | 82 | 5 | 3 | 10 | 6 | 38 | 0 | 60.0% | 3.80 | 6.33 | 48 | 2 | 1 | 0 | 0 | 83 |
| 26 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 16 | 52 | 3.25 | 2 | 65 | 7 | 3 | 12 | 10 | 47 | 1 | 83.3% | 3.92 | 4.70 | 71 | 5 | 4 | 1 | 0 | 69 |
| 27 | Quinshon JudkinsCleveland Browns·#10 | 12 | 24 | 67 | 2.79 | 1 | 61 | 4 | 3 | 2 | 2 | -8 | 0 | 100.0% | -4.00 | -4.00 | 1 | 0 | 0 | 0 | 0 | 38 |
| 28 | Rico DowdleCarolina Panthers·#5 | 17 | 29 | 138 | 4.76 | 2 | 120 | 8 | 3 | 6 | 6 | 30 | 0 | 100.0% | 5.00 | 5.00 | 57 | 1 | 1 | 0 | 0 | 79 |
| 29 | Bhayshul TutenJacksonville Jaguars·#33 | 11 | 13 | 37 | 2.85 | 2 | 20 | 3 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 28 |
| 30 | David MontgomeryDetroit Lions·#5 | 16 | 19 | 58 | 3.05 | 0 | 26 | 3 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 50 |
| 31 | Nick ChubbHouston Texans·#21 | 11 | 10 | 37 | 3.70 | 1 | 24 | 3 | 2 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 0 | 0 | 0 | 0 | 0 | 29 |
| 32 | Aaron JonesMinnesota Vikings·#33 | 12 | 12 | 54 | 4.50 | 1 | 43 | 5 | 2 | 9 | 5 | 15 | 0 | 55.6% | 1.67 | 3.00 | 25 | 2 | 1 | 0 | 1 | 54 |
| 33 | Woody MarksHouston Texans·#27 | 14 | 23 | 95 | 4.13 | 0 | 51 | 7 | 2 | 5 | 3 | 91 | 1 | 60.0% | 18.20 | 30.33 | 82 | 1 | 1 | 1 | 0 | 78 |
| 34 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 21 | 136 | 6.48 | 1 | 69 | 12 | 2 | 4 | 2 | 33 | 1 | 50.0% | 8.25 | 16.50 | 24 | 1 | 1 | 1 | 1 | 60 |
| 35 | Jerome FordCleveland Browns·#34 | 12 | 3 | 7 | 2.33 | 0 | 7 | 0 | 2 | 7 | 5 | 19 | 0 | 71.4% | 2.71 | 3.80 | 22 | 1 | 0 | 0 | 1 | 46 |
| 36 | Cam SkatteboNew York Giants·#44 | 8 | 16 | 35 | 2.19 | 1 | 28 | 3 | 2 | 6 | 5 | 24 | 0 | 83.3% | 4.00 | 4.80 | 24 | 0 | 0 | 0 | 0 | 45 |
| 37 | Kareem HuntKansas City Chiefs·#29 | 17 | 17 | 44 | 2.59 | 1 | 19 | 2 | 2 | 2 | 2 | 21 | 0 | 100.0% | 10.50 | 10.50 | 21 | 0 | 0 | 0 | 0 | 63 |
| 38 | Tyjae SpearsTennessee Titans·#2 | 13 | 12 | 78 | 6.50 | 1 | 30 | 5 | 1 | 7 | 7 | 24 | 0 | 100.0% | 3.43 | 3.43 | 56 | 1 | 1 | 0 | 0 | 64 |
| 39 | Ashton JeantyLas Vegas Raiders·#2 | 16 | 28 | 106 | 3.79 | 0 | 112 | 8 | 1 | 5 | 4 | 96 | 2 | 80.0% | 19.20 | 24.00 | 68 | 1 | 1 | 1 | 0 | 98 |
| 40 | Audric EstiméNew Orleans Saints·#30 | 5 | 6 | 33 | 5.50 | 0 | 16 | 3 | 1 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 8 | 0 | 0 | 0 | 0 | 26 |
| 41 | Kenneth Walker IIISeattle Seahawks·#9 | 16 | 26 | 91 | 3.50 | 0 | 81 | 4 | 1 | 5 | 3 | 22 | 0 | 60.0% | 4.40 | 7.33 | 22 | 1 | 1 | 0 | 2 | 52 |
| 42 | Kimani VidalLos Angeles Chargers·#30 | 12 | 13 | 34 | 2.62 | 0 | 29 | 5 | 1 | 2 | 2 | 16 | 0 | 100.0% | 8.00 | 8.00 | 22 | 1 | 1 | 0 | 0 | 73 |
| 43 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 8 | 15 | 1.88 | 0 | 21 | 1 | 1 | 4 | 3 | 28 | 0 | 75.0% | 7.00 | 9.33 | 29 | 2 | 2 | 0 | 0 | 71 |
| 44 | Jeremy McNicholsWashington Commanders·#26 | 15 | 7 | 83 | 11.86 | 1 | 73 | 4 | 1 | 5 | 2 | 24 | 0 | 40.0% | 4.80 | 12.00 | 24 | 0 | 0 | 0 | 1 | 46 |
| 45 | Bam KnightArizona Cardinals·#20 | 7 | 9 | 28 | 3.11 | 1 | 19 | 4 | 1 | 2 | 2 | 6 | 0 | 100.0% | 3.00 | 3.00 | 1 | 1 | 1 | 0 | 0 | 30 |
| 46 | Dare OgunbowaleHouston Texans·#33 | 13 | 2 | 8 | 4.00 | 1 | 8 | 1 | 1 | 3 | 2 | 10 | 0 | 66.7% | 3.33 | 5.00 | 5 | 1 | 1 | 0 | 0 | 30 |
| 47 | Breece HallNew York Jets·#20 | 16 | 37 | 113 | 3.05 | 0 | 59 | 7 | 1 | 6 | 2 | 22 | 0 | 33.3% | 3.67 | 11.00 | 12 | 3 | 1 | 0 | 2 | 94 |
| 48 | Brashard SmithKansas City Chiefs·#24 | 14 | 7 | 28 | 4.00 | 0 | 21 | 2 | 1 | 5 | 5 | 11 | 1 | 100.0% | 2.20 | 2.20 | 19 | 3 | 3 | 1 | 0 | 29 |
| 49 | Devin SingletaryNew York Giants·#26 | 14 | 22 | 137 | 6.23 | 3 | 66 | 9 | 1 | 4 | 4 | 25 | 0 | 100.0% | 6.25 | 6.25 | 30 | 2 | 2 | 0 | 0 | 50 |
| 50 | Emanuel WilsonGreen Bay Packers·#23 | 14 | 20 | 95 | 4.75 | 0 | 57 | 8 | 1 | 3 | 2 | 6 | 0 | 66.7% | 2.00 | 3.00 | 10 | 1 | 0 | 0 | 0 | 45 |