| 1 | Derrick HenryBaltimore Ravens·#22 | 17 | 157 | 801 | 5.10 | 9 | 466 | 42 | 14 | 9 | 7 | 47 | 0 | 77.8% | 5.22 | 6.71 | 41 | 1 | 1 | 0 | 1 | 266 |
| 2 | David MontgomeryDetroit Lions·#5 | 17 | 85 | 303 | 3.56 | 5 | 197 | 23 | 14 | 13 | 12 | 82 | 0 | 92.3% | 6.31 | 6.83 | 90 | 0 | 0 | 0 | 3 | 206 |
| 3 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 165 | 669 | 4.05 | 7 | 367 | 41 | 14 | 32 | 25 | 242 | 1 | 78.1% | 7.56 | 9.68 | 258 | 2 | 2 | 1 | 2 | 470 |
| 4 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 132 | 653 | 4.95 | 6 | 403 | 40 | 12 | 23 | 16 | 105 | 1 | 69.6% | 4.57 | 6.56 | 67 | 5 | 3 | 1 | 1 | 372 |
| 5 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 137 | 606 | 4.42 | 4 | 279 | 26 | 11 | 29 | 22 | 120 | 1 | 75.9% | 4.14 | 5.45 | 161 | 6 | 4 | 1 | 1 | 349 |
| 6 | Javonte WilliamsDallas Cowboys·#33 | 16 | 133 | 623 | 4.68 | 7 | 368 | 37 | 11 | 25 | 16 | 72 | 0 | 64.0% | 2.88 | 4.50 | 113 | 5 | 3 | 0 | 3 | 365 |
| 7 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 108 | 454 | 4.20 | 3 | 266 | 26 | 9 | 24 | 23 | 121 | 0 | 95.8% | 5.04 | 5.26 | 180 | 1 | 1 | 0 | 0 | 242 |
| 8 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 84 | 353 | 4.20 | 6 | 234 | 25 | 9 | 8 | 6 | 42 | 0 | 75.0% | 5.25 | 7.00 | 35 | 0 | 0 | 0 | 2 | 214 |
| 9 | Quinshon JudkinsCleveland Browns·#10 | 14 | 127 | 415 | 3.27 | 5 | 272 | 27 | 9 | 18 | 14 | 124 | 0 | 77.8% | 6.89 | 8.86 | 151 | 1 | 1 | 0 | 1 | 237 |
| 10 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 153 | 641 | 4.19 | 6 | 381 | 39 | 9 | 64 | 48 | 316 | 5 | 75.0% | 4.94 | 6.58 | 231 | 13 | 11 | 5 | 3 | 459 |
| 11 | Blake CorumLos Angeles Rams·#22 | 16 | 69 | 350 | 5.07 | 2 | 163 | 24 | 8 | 4 | 2 | -11 | 0 | 50.0% | -2.75 | -5.50 | 2 | 0 | 0 | 0 | 1 | 161 |
| 12 | Jahmyr GibbsDetroit Lions·#0 | 17 | 127 | 626 | 4.93 | 6 | 365 | 31 | 7 | 46 | 39 | 291 | 3 | 84.8% | 6.33 | 7.46 | 290 | 9 | 6 | 3 | 2 | 350 |
| 13 | Chris Rodriguez Jr.Washington Commanders·#36 | 11 | 55 | 293 | 5.33 | 3 | 159 | 20 | 7 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 1 | 116 |
| 14 | Bam KnightArizona Cardinals·#20 | 10 | 48 | 157 | 3.27 | 4 | 112 | 13 | 6 | 13 | 9 | 60 | 0 | 69.2% | 4.62 | 6.67 | 63 | 1 | 1 | 0 | 1 | 141 |
| 15 | Devin SingletaryNew York Giants·#26 | 17 | 56 | 202 | 3.61 | 3 | 107 | 13 | 6 | 8 | 7 | 28 | 0 | 87.5% | 3.50 | 4.00 | 37 | 0 | 0 | 0 | 1 | 112 |
| 16 | Josh JacobsGreen Bay Packers·#8 | 15 | 111 | 436 | 3.93 | 2 | 308 | 26 | 6 | 25 | 23 | 169 | 1 | 92.0% | 6.76 | 7.35 | 188 | 3 | 3 | 1 | 3 | 269 |
| 17 | Jacory Croskey-MerrittWashington Commanders·#22 | 16 | 80 | 340 | 4.25 | 5 | 164 | 20 | 6 | 5 | 4 | 16 | 0 | 80.0% | 3.20 | 4.00 | 28 | 0 | 0 | 0 | 1 | 179 |
| 18 | TreVeyon HendersonNew England Patriots·#32 | 17 | 95 | 421 | 4.43 | 5 | 178 | 25 | 6 | 23 | 21 | 155 | 0 | 91.3% | 6.74 | 7.38 | 160 | 1 | 1 | 0 | 1 | 244 |
| 19 | Woody MarksHouston Texans·#27 | 16 | 99 | 391 | 3.95 | 1 | 271 | 27 | 6 | 23 | 16 | 144 | 1 | 69.6% | 6.26 | 9.00 | 159 | 3 | 2 | 1 | 0 | 277 |
| 20 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 81 | 368 | 4.54 | 2 | 207 | 22 | 6 | 21 | 20 | 104 | 0 | 95.2% | 4.95 | 5.20 | 161 | 6 | 6 | 0 | 2 | 257 |
| 21 | Kyle MonangaiChicago Bears·#25 | 17 | 81 | 356 | 4.40 | 3 | 154 | 22 | 6 | 11 | 5 | 33 | 0 | 45.5% | 3.00 | 6.60 | 24 | 0 | 0 | 0 | 0 | 210 |
| 22 | J.K. DobbinsDenver Broncos·#27 | 10 | 56 | 229 | 4.09 | 0 | 131 | 11 | 5 | 7 | 4 | 22 | 0 | 57.1% | 3.14 | 5.50 | 22 | 0 | 0 | 0 | 1 | 146 |
| 23 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 102 | 392 | 3.84 | 2 | 220 | 18 | 5 | 16 | 14 | 157 | 0 | 87.5% | 9.81 | 11.21 | 194 | 2 | 1 | 0 | 2 | 211 |
| 24 | Chase BrownCincinnati Bengals·#30 | 17 | 126 | 607 | 4.82 | 2 | 386 | 27 | 5 | 38 | 29 | 189 | 3 | 76.3% | 4.97 | 6.52 | 188 | 4 | 4 | 3 | 2 | 349 |
| 25 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 160 | 970 | 6.06 | 5 | 625 | 39 | 5 | 53 | 38 | 328 | 3 | 71.7% | 6.19 | 8.63 | 367 | 9 | 6 | 2 | 3 | 428 |
| 26 | Sean TuckerTampa Bay Buccaneers·#44 | 15 | 40 | 181 | 4.53 | 3 | 95 | 11 | 5 | 5 | 3 | -3 | 0 | 60.0% | -0.60 | -1.00 | 9 | 2 | 1 | 0 | 0 | 82 |
| 27 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 143 | 585 | 4.09 | 2 | 464 | 26 | 4 | 40 | 27 | 167 | 1 | 67.5% | 4.18 | 6.19 | 206 | 6 | 5 | 1 | 1 | 386 |
| 28 | James CookBuffalo Bills·#4 | 17 | 146 | 924 | 6.33 | 7 | 562 | 38 | 4 | 14 | 11 | 38 | 1 | 78.6% | 2.71 | 3.45 | 48 | 2 | 2 | 1 | 4 | 269 |
| 29 | Kimani VidalLos Angeles Chargers·#30 | 13 | 72 | 267 | 3.71 | 1 | 187 | 21 | 4 | 11 | 9 | 110 | 0 | 81.8% | 10.00 | 12.22 | 136 | 1 | 0 | 0 | 0 | 225 |
| 30 | Nick ChubbHouston Texans·#21 | 15 | 59 | 210 | 3.56 | 1 | 149 | 9 | 4 | 14 | 8 | 40 | 0 | 57.1% | 2.86 | 5.00 | 52 | 2 | 1 | 0 | 0 | 165 |
| 31 | Travis EtienneJacksonville Jaguars·#1 | 17 | 112 | 578 | 5.16 | 4 | 362 | 24 | 4 | 26 | 16 | 99 | 2 | 61.5% | 3.81 | 6.19 | 105 | 5 | 4 | 2 | 1 | 305 |
| 32 | Samaje PerineCincinnati Bengals·#34 | 15 | 44 | 198 | 4.50 | 2 | 135 | 20 | 4 | 16 | 13 | 65 | 0 | 81.3% | 4.06 | 5.00 | 76 | 0 | 0 | 0 | 2 | 167 |
| 33 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 56 | 263 | 4.70 | 3 | 182 | 17 | 4 | 47 | 42 | 273 | 2 | 89.4% | 5.81 | 6.50 | 304 | 10 | 9 | 1 | 0 | 240 |
| 34 | Rhamondre StevensonNew England Patriots·#38 | 14 | 79 | 448 | 5.67 | 2 | 236 | 21 | 4 | 19 | 18 | 168 | 1 | 94.7% | 8.84 | 9.33 | 125 | 3 | 3 | 0 | 3 | 262 |
| 35 | Aaron JonesMinnesota Vikings·#33 | 12 | 77 | 312 | 4.05 | 2 | 206 | 16 | 3 | 27 | 20 | 122 | 0 | 74.1% | 4.52 | 6.10 | 151 | 3 | 2 | 0 | 1 | 204 |
| 36 | Cam SkatteboNew York Giants·#44 | 8 | 46 | 190 | 4.13 | 2 | 135 | 12 | 3 | 16 | 11 | 100 | 2 | 68.8% | 6.25 | 9.09 | 100 | 2 | 2 | 2 | 0 | 119 |
| 37 | Bhayshul TutenJacksonville Jaguars·#33 | 15 | 36 | 150 | 4.17 | 2 | 102 | 11 | 3 | 11 | 8 | 65 | 2 | 72.7% | 5.91 | 8.12 | 68 | 2 | 2 | 2 | 1 | 104 |
| 38 | Michael CarterArizona Cardinals·#22 | 13 | 44 | 171 | 3.89 | 1 | 117 | 8 | 3 | 16 | 12 | 89 | 0 | 75.0% | 5.56 | 7.42 | 77 | 3 | 3 | 0 | 0 | 150 |
| 39 | Ollie Gordon IIMiami Dolphins·#31 | 16 | 33 | 83 | 2.52 | 1 | 42 | 11 | 3 | 3 | 1 | 3 | 0 | 33.3% | 1.00 | 3.00 | 7 | 1 | 1 | 0 | 1 | 92 |
| 40 | RJ HarveyDenver Broncos·#12 | 17 | 71 | 248 | 3.49 | 2 | 118 | 12 | 3 | 22 | 18 | 99 | 0 | 81.8% | 4.50 | 5.50 | 125 | 2 | 2 | 0 | 1 | 209 |
| 41 | Rico DowdleCarolina Panthers·#5 | 17 | 113 | 513 | 4.54 | 3 | 284 | 29 | 3 | 24 | 18 | 112 | 0 | 75.0% | 4.67 | 6.22 | 135 | 3 | 2 | 0 | 3 | 260 |
| 42 | Jaylen WrightMiami Dolphins·#5 | 9 | 37 | 162 | 4.38 | 1 | 115 | 7 | 3 | 3 | 2 | 17 | 0 | 66.7% | 5.67 | 8.50 | 25 | 0 | 0 | 0 | 1 | 57 |
| 43 | Kareem HuntKansas City Chiefs·#29 | 17 | 72 | 327 | 4.54 | 1 | 194 | 29 | 3 | 12 | 12 | 94 | 0 | 100.0% | 7.83 | 7.83 | 100 | 0 | 0 | 0 | 0 | 228 |
| 44 | Jerome FordCleveland Browns·#34 | 13 | 11 | 31 | 2.82 | 0 | 24 | 2 | 3 | 9 | 8 | 59 | 0 | 88.9% | 6.56 | 7.38 | 85 | 2 | 2 | 0 | 0 | 92 |
| 45 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 52 | 190 | 3.65 | 4 | 88 | 17 | 3 | 8 | 8 | 39 | 0 | 100.0% | 4.88 | 4.88 | 36 | 1 | 1 | 0 | 1 | 121 |
| 46 | Jordan MasonMinnesota Vikings·#27 | 16 | 78 | 296 | 3.79 | 2 | 161 | 22 | 2 | 8 | 8 | 27 | 0 | 100.0% | 3.38 | 3.38 | 58 | 1 | 1 | 0 | 1 | 178 |
| 47 | Ty JohnsonBuffalo Bills·#26 | 17 | 24 | 119 | 4.96 | 3 | 63 | 8 | 2 | 18 | 13 | 165 | 1 | 72.2% | 9.17 | 12.69 | 175 | 2 | 1 | 0 | 0 | 145 |
| 48 | Breece HallNew York Jets·#20 | 16 | 129 | 515 | 3.99 | 1 | 260 | 26 | 2 | 24 | 19 | 152 | 0 | 79.2% | 6.33 | 8.00 | 148 | 4 | 1 | 0 | 2 | 262 |
| 49 | Devin NealNew Orleans Saints·#24 | 9 | 24 | 89 | 3.71 | 2 | 53 | 7 | 2 | 7 | 6 | 26 | 0 | 85.7% | 3.71 | 4.33 | 25 | 0 | 0 | 0 | 0 | 97 |
| 50 | Audric EstiméNew Orleans Saints·#30 | 5 | 14 | 33 | 2.36 | 0 | 34 | 2 | 2 | 7 | 6 | 39 | 0 | 85.7% | 5.57 | 6.50 | 32 | 0 | 0 | 0 | 0 | 65 |