| 1 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 17 | 47 | 2.76 | 3 | 62 | 5 | 3 | 16 | 14 | 166 | 0 | 87.5% | 10.38 | 11.86 | 126 | 2 | 2 | 0 | 1 | 80 |
| 2 | Jahmyr GibbsDetroit Lions·#0 | 13 | 17 | 58 | 3.41 | 1 | 36 | 5 | 0 | 15 | 13 | 100 | 1 | 86.7% | 6.67 | 7.69 | 74 | 5 | 5 | 1 | 0 | 92 |
| 3 | Tony PollardTennessee Titans·#20 | 15 | 15 | 47 | 3.13 | 0 | 57 | 3 | 0 | 12 | 12 | 65 | 0 | 100.0% | 5.42 | 5.42 | 64 | 0 | 0 | 0 | 4 | 69 |
| 4 | Chase BrownCincinnati Bengals·#30 | 13 | 15 | 31 | 2.07 | 0 | 38 | 6 | 2 | 14 | 10 | 78 | 0 | 71.4% | 5.57 | 7.80 | 62 | 1 | 0 | 0 | 1 | 77 |
| 5 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 16 | 35 | 2.19 | 0 | 67 | 1 | 0 | 9 | 8 | 60 | 0 | 88.9% | 6.67 | 7.50 | 91 | 0 | 0 | 0 | 0 | 54 |
| 6 | Tyjae SpearsTennessee Titans·#2 | 10 | 5 | 14 | 2.80 | 1 | 11 | 1 | 1 | 9 | 8 | 25 | 0 | 88.9% | 2.78 | 3.12 | 50 | 3 | 3 | 0 | 0 | 48 |
| 7 | Michael CarterArizona Cardinals·#22 | 12 | 9 | 37 | 4.11 | 0 | 34 | 4 | 0 | 8 | 7 | 67 | 0 | 87.5% | 8.38 | 9.57 | 57 | 1 | 0 | 0 | 0 | 58 |
| 8 | Kenneth GainwellPittsburgh Steelers·#14 | 15 | 12 | 32 | 2.67 | 1 | 33 | 2 | 2 | 7 | 7 | 53 | 1 | 100.0% | 7.57 | 7.57 | 59 | 2 | 2 | 1 | 0 | 68 |
| 9 | Jerome FordCleveland Browns·#34 | 12 | 3 | 20 | 6.67 | 0 | 21 | 1 | 0 | 8 | 7 | 17 | 0 | 87.5% | 2.12 | 2.43 | 28 | 4 | 3 | 0 | 0 | 57 |
| 10 | Rico DowdleCarolina Panthers·#5 | 14 | 19 | 76 | 4.00 | 0 | 47 | 2 | 0 | 9 | 7 | 53 | 0 | 77.8% | 5.89 | 7.57 | 68 | 1 | 0 | 0 | 1 | 61 |
| 11 | RJ HarveyDenver Broncos·#12 | 12 | 16 | 60 | 3.75 | 0 | 41 | 4 | 1 | 8 | 7 | 28 | 2 | 87.5% | 3.50 | 4.00 | 48 | 4 | 3 | 2 | 0 | 50 |
| 12 | Rachaad WhiteTampa Bay Buccaneers·#1 | 12 | 8 | 29 | 3.62 | 1 | 29 | 3 | 1 | 9 | 7 | 33 | 0 | 77.8% | 3.67 | 4.71 | 47 | 1 | 0 | 0 | 2 | 63 |
| 13 | De'Von AchaneMiami Dolphins·#28 | 10 | 21 | 102 | 4.86 | 1 | 52 | 4 | 2 | 6 | 6 | 78 | 0 | 100.0% | 13.00 | 13.00 | 66 | 0 | 0 | 0 | 0 | 67 |
| 14 | Jeremy McNicholsWashington Commanders·#26 | 9 | 9 | 35 | 3.89 | 0 | 19 | 4 | 1 | 6 | 5 | 36 | 0 | 83.3% | 6.00 | 7.20 | 35 | 0 | 0 | 0 | 0 | 51 |
| 15 | Bijan RobinsonAtlanta Falcons·#7 | 12 | 16 | 54 | 3.38 | 0 | 50 | 3 | 2 | 6 | 4 | 43 | 0 | 66.7% | 7.17 | 10.75 | 27 | 0 | 0 | 0 | 0 | 72 |
| 16 | Dylan SampsonCleveland Browns·#22 | 10 | 11 | 18 | 1.64 | 0 | 32 | 0 | 0 | 6 | 4 | 55 | 1 | 66.7% | 9.17 | 13.75 | 41 | 2 | 1 | 1 | 0 | 32 |
| 17 | Tyrone Tracy Jr.New York Giants·#29 | 11 | 11 | 50 | 4.55 | 0 | 34 | 2 | 1 | 4 | 4 | 14 | 0 | 100.0% | 3.50 | 3.50 | 15 | 0 | 0 | 0 | 1 | 53 |
| 18 | Saquon BarkleyPhiladelphia Eagles·#26 | 12 | 27 | 47 | 1.74 | 0 | 44 | 3 | 1 | 6 | 4 | 20 | 0 | 66.7% | 3.33 | 5.00 | 12 | 2 | 1 | 0 | 0 | 74 |
| 19 | J.K. DobbinsDenver Broncos·#27 | 7 | 19 | 64 | 3.37 | 0 | 45 | 3 | 0 | 4 | 4 | 5 | 0 | 100.0% | 1.25 | 1.25 | 14 | 0 | 0 | 0 | 0 | 36 |
| 20 | Javonte WilliamsDallas Cowboys·#33 | 10 | 12 | 35 | 2.92 | 1 | 20 | 2 | 2 | 6 | 4 | 16 | 1 | 66.7% | 2.67 | 4.00 | 5 | 2 | 1 | 1 | 1 | 60 |
| 21 | Isaiah DavisNew York Jets·#32 | 10 | 2 | 2 | 1.00 | 0 | 4 | 1 | 0 | 4 | 3 | 30 | 0 | 75.0% | 7.50 | 10.00 | 15 | 1 | 1 | 0 | 0 | 52 |
| 22 | Devin NealNew Orleans Saints·#24 | 6 | 5 | 8 | 1.60 | 0 | 6 | 0 | 0 | 3 | 3 | 14 | 0 | 100.0% | 4.67 | 4.67 | 17 | 0 | 0 | 0 | 0 | 57 |
| 23 | D'Andre SwiftChicago Bears·#4 | 12 | 17 | 75 | 4.41 | 1 | 40 | 5 | 1 | 4 | 3 | 21 | 0 | 75.0% | 5.25 | 7.00 | 21 | 0 | 0 | 0 | 1 | 59 |
| 24 | Raheem MostertLas Vegas Raiders·#31 | 5 | 7 | 23 | 3.29 | 0 | 10 | 1 | 0 | 3 | 3 | 26 | 0 | 100.0% | 8.67 | 8.67 | 22 | 0 | 0 | 0 | 1 | 30 |
| 25 | Emari DemercadoArizona Cardinals·#31 | 7 | 9 | 40 | 4.44 | 0 | 11 | 1 | 0 | 3 | 3 | 20 | 1 | 100.0% | 6.67 | 6.67 | 23 | 1 | 1 | 1 | 0 | 31 |
| 26 | Ashton JeantyLas Vegas Raiders·#2 | 10 | 11 | 26 | 2.36 | 0 | 27 | 1 | 0 | 4 | 3 | 21 | 0 | 75.0% | 5.25 | 7.00 | 29 | 0 | 0 | 0 | 0 | 37 |
| 27 | Alvin KamaraNew Orleans Saints·#41 | 7 | 3 | 2 | 0.67 | 0 | 11 | 0 | 1 | 3 | 3 | 15 | 0 | 100.0% | 5.00 | 5.00 | 22 | 0 | 0 | 0 | 0 | 42 |
| 28 | Samaje PerineCincinnati Bengals·#34 | 11 | 9 | 16 | 1.78 | 0 | 19 | 0 | 0 | 3 | 3 | 21 | 0 | 100.0% | 7.00 | 7.00 | 26 | 1 | 1 | 0 | 0 | 46 |
| 29 | Kyren WilliamsLos Angeles Rams·#23 | 14 | 41 | 202 | 4.93 | 0 | 107 | 13 | 1 | 5 | 3 | 22 | 0 | 60.0% | 4.40 | 7.33 | 16 | 0 | 0 | 0 | 3 | 87 |
| 30 | Ollie Gordon IIMiami Dolphins·#31 | 12 | 10 | 14 | 1.40 | 0 | 15 | 2 | 1 | 3 | 3 | 5 | 0 | 100.0% | 1.67 | 1.67 | 16 | 0 | 0 | 0 | 0 | 31 |
| 31 | Woody MarksHouston Texans·#27 | 11 | 26 | 91 | 3.50 | 1 | 64 | 6 | 1 | 4 | 3 | 19 | 1 | 75.0% | 4.75 | 6.33 | 17 | 2 | 1 | 1 | 0 | 59 |
| 32 | Kyle MonangaiChicago Bears·#25 | 12 | 21 | 78 | 3.71 | 0 | 46 | 3 | 0 | 5 | 3 | 35 | 0 | 60.0% | 7.00 | 11.67 | 26 | 0 | 0 | 0 | 0 | 62 |
| 33 | Ty JohnsonBuffalo Bills·#26 | 11 | 7 | 17 | 2.43 | 0 | 13 | 2 | 0 | 4 | 2 | 8 | 0 | 50.0% | 2.00 | 4.00 | 12 | 1 | 0 | 0 | 0 | 44 |
| 34 | Zach CharbonnetSeattle Seahawks·#26 | 13 | 24 | 75 | 3.12 | 1 | 62 | 4 | 2 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 11 | 0 | 0 | 0 | 0 | 58 |
| 35 | Travis EtienneJacksonville Jaguars·#1 | 11 | 23 | 130 | 5.65 | 1 | 74 | 7 | 0 | 3 | 2 | 19 | 0 | 66.7% | 6.33 | 9.50 | 17 | 0 | 0 | 0 | 0 | 46 |
| 36 | Breece HallNew York Jets·#20 | 14 | 11 | 23 | 2.09 | 0 | 12 | 2 | 0 | 4 | 2 | 20 | 0 | 50.0% | 5.00 | 10.00 | 19 | 1 | 0 | 0 | 0 | 65 |
| 37 | Emanuel WilsonGreen Bay Packers·#23 | 10 | 20 | 76 | 3.80 | 0 | 52 | 3 | 0 | 3 | 2 | 23 | 0 | 66.7% | 7.67 | 11.50 | 22 | 1 | 0 | 0 | 0 | 38 |
| 38 | Isiah PachecoKansas City Chiefs·#10 | 8 | 3 | 8 | 2.67 | 0 | 1 | 0 | 0 | 2 | 2 | 3 | 0 | 100.0% | 1.50 | 1.50 | 10 | 0 | 0 | 0 | 0 | 27 |
| 39 | Aaron JonesMinnesota Vikings·#33 | 7 | 18 | 56 | 3.11 | 0 | 35 | 3 | 0 | 4 | 2 | 12 | 0 | 50.0% | 3.00 | 6.00 | 14 | 1 | 1 | 0 | 0 | 42 |
| 40 | Devin SingletaryNew York Giants·#26 | 12 | 10 | 25 | 2.50 | 0 | 37 | 1 | 1 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 23 | 0 | 0 | 0 | 0 | 44 |
| 41 | James CookBuffalo Bills·#4 | 13 | 34 | 81 | 2.38 | 0 | 47 | 1 | 2 | 3 | 2 | 17 | 0 | 66.7% | 5.67 | 8.50 | 14 | 0 | 0 | 0 | 0 | 61 |
| 42 | Derrick HenryBaltimore Ravens·#22 | 10 | 23 | 74 | 3.22 | 2 | 28 | 4 | 3 | 2 | 1 | 8 | 0 | 50.0% | 4.00 | 8.00 | 5 | 1 | 1 | 0 | 1 | 37 |
| 43 | Chuba HubbardCarolina Panthers·#30 | 10 | 4 | 8 | 2.00 | 0 | 27 | 0 | 0 | 2 | 1 | 27 | 1 | 50.0% | 13.50 | 27.00 | 24 | 0 | 0 | 0 | 1 | 44 |
| 44 | Josh JacobsGreen Bay Packers·#8 | 10 | 27 | 72 | 2.67 | 3 | 67 | 6 | 5 | 2 | 1 | 25 | 0 | 50.0% | 12.50 | 25.00 | 25 | 0 | 0 | 0 | 1 | 48 |
| 45 | Rhamondre StevensonNew England Patriots·#38 | 10 | 10 | 51 | 5.10 | 1 | 41 | 2 | 0 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 6 | 0 | 0 | 0 | 0 | 45 |
| 46 | TreVeyon HendersonNew England Patriots·#32 | 10 | 13 | 102 | 7.85 | 1 | 17 | 3 | 0 | 3 | 1 | 8 | 0 | 33.3% | 2.67 | 8.00 | 8 | 0 | 0 | 0 | 1 | 26 |
| 47 | Jaret PattersonLos Angeles Chargers·#32 | 5 | 11 | 35 | 3.18 | 1 | 28 | 3 | 2 | 2 | 1 | 4 | 0 | 50.0% | 2.00 | 4.00 | 3 | 0 | 0 | 0 | 0 | 28 |
| 48 | Jaylen WrightMiami Dolphins·#5 | 4 | 11 | 36 | 3.27 | 1 | 23 | 4 | 1 | 2 | 1 | 0 | 0 | 50.0% | 0.00 | 0.00 | 3 | 0 | 0 | 0 | 0 | 25 |
| 49 | Jordan MasonMinnesota Vikings·#27 | 8 | 12 | 31 | 2.58 | 0 | 29 | 1 | 2 | 2 | 1 | 2 | 0 | 50.0% | 1.00 | 2.00 | 7 | 0 | 0 | 0 | 0 | 47 |
| 50 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 10 | 8 | 41 | 5.12 | 0 | 19 | 2 | 0 | 1 | 1 | 4 | 0 | 100.0% | 4.00 | 4.00 | 3 | 1 | 1 | 0 | 1 | 31 |