| 1 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 75 | 122 | 1.63 | 10 | 128 | 17 | 20 | 24 | 20 | 118 | 7 | 83.3% | 4.92 | 5.90 | 68 | 0 | 169 |
| 2 | Kenneth GainwellPittsburgh Steelers·#14 | 15 | 23 | 49 | 2.13 | 5 | 62 | 8 | 9 | 17 | 14 | 74 | 2 | 82.3% | 4.35 | 5.29 | 81 | 0 | 71 |
| 3 | Jahmyr GibbsDetroit Lions·#0 | 17 | 52 | 168 | 3.23 | 9 | 86 | 17 | 10 | 15 | 12 | 109 | 5 | 80.0% | 7.27 | 9.08 | 87 | 0 | 115 |
| 4 | Bijan RobinsonAtlanta Falcons·#7 | 16 | 36 | 92 | 2.56 | 5 | 98 | 6 | 11 | 13 | 9 | 71 | 3 | 69.2% | 5.46 | 7.89 | 72 | 2 | 101 |
| 5 | Javonte WilliamsDallas Cowboys·#33 | 16 | 54 | 159 | 2.94 | 10 | 90 | 18 | 20 | 12 | 8 | 29 | 2 | 66.7% | 2.42 | 3.62 | 43 | 0 | 135 |
| 6 | Chase BrownCincinnati Bengals·#30 | 17 | 37 | 116 | 3.14 | 6 | 85 | 12 | 13 | 11 | 8 | 65 | 5 | 72.7% | 5.91 | 8.12 | 28 | 0 | 110 |
| 7 | RJ HarveyDenver Broncos·#12 | 14 | 29 | 53 | 1.83 | 5 | 27 | 6 | 10 | 11 | 9 | 49 | 4 | 81.8% | 4.45 | 5.44 | 60 | 0 | 88 |
| 8 | De'Von AchaneMiami Dolphins·#28 | 16 | 32 | 97 | 3.03 | 3 | 78 | 7 | 5 | 11 | 7 | 51 | 3 | 63.6% | 4.64 | 7.29 | 48 | 0 | 89 |
| 9 | Rachaad WhiteTampa Bay Buccaneers·#1 | 16 | 19 | 41 | 2.16 | 4 | 35 | 11 | 9 | 10 | 9 | 48 | 0 | 90.0% | 4.80 | 5.33 | 81 | 0 | 82 |
| 10 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 53 | 148 | 2.79 | 10 | 82 | 17 | 18 | 10 | 8 | 60 | 3 | 80.0% | 6.00 | 7.50 | 33 | 2 | 138 |
| 11 | Ashton JeantyLas Vegas Raiders·#2 | 15 | 34 | 55 | 1.62 | 2 | 82 | 6 | 10 | 10 | 9 | 44 | 4 | 90.0% | 4.40 | 4.89 | 64 | 0 | 92 |
| 12 | Travis EtienneJacksonville Jaguars·#1 | 16 | 54 | 157 | 2.91 | 5 | 106 | 14 | 12 | 10 | 8 | 77 | 5 | 80.0% | 7.70 | 9.62 | 62 | 1 | 123 |
| 13 | Breece HallNew York Jets·#20 | 15 | 24 | 40 | 1.67 | 2 | 30 | 2 | 4 | 9 | 2 | 13 | 0 | 22.2% | 1.44 | 6.50 | 13 | 1 | 66 |
| 14 | Woody MarksHouston Texans·#27 | 14 | 33 | 64 | 1.94 | 2 | 62 | 6 | 9 | 8 | 5 | 19 | 3 | 62.5% | 2.38 | 3.80 | 21 | 0 | 94 |
| 15 | Saquon BarkleyPhiladelphia Eagles·#26 | 15 | 42 | 83 | 1.98 | 5 | 61 | 10 | 14 | 8 | 5 | 22 | 1 | 62.5% | 2.75 | 4.40 | 14 | 0 | 96 |
| 16 | Tyjae SpearsTennessee Titans·#2 | 11 | 10 | 30 | 3.00 | 2 | 17 | 3 | 2 | 7 | 7 | 14 | 0 | 100.0% | 2.00 | 2.00 | 42 | 0 | 37 |
| 17 | Michael CarterArizona Cardinals·#22 | 11 | 8 | 10 | 1.25 | 1 | 15 | 3 | 3 | 7 | 4 | 19 | 0 | 57.1% | 2.71 | 4.75 | 19 | 1 | 57 |
| 18 | Brashard SmithKansas City Chiefs·#24 | 15 | 10 | 26 | 2.60 | 0 | 14 | 0 | 1 | 7 | 6 | 29 | 1 | 85.7% | 4.14 | 4.83 | 25 | 0 | 38 |
| 19 | Josh JacobsGreen Bay Packers·#8 | 15 | 52 | 153 | 2.94 | 12 | 103 | 16 | 20 | 6 | 5 | 29 | 1 | 83.3% | 4.83 | 5.80 | 19 | 2 | 97 |
| 20 | Rhamondre StevensonNew England Patriots·#38 | 14 | 27 | 51 | 1.89 | 5 | 27 | 6 | 12 | 6 | 5 | 42 | 1 | 83.3% | 7.00 | 8.40 | 11 | 1 | 80 |
| 21 | Bam KnightArizona Cardinals·#20 | 9 | 17 | 25 | 1.47 | 4 | 24 | 7 | 8 | 6 | 4 | 29 | 1 | 66.7% | 4.83 | 7.25 | 10 | 0 | 48 |
| 22 | Jerome FordCleveland Browns·#34 | 10 | 4 | 7 | 1.75 | 0 | 9 | 0 | 3 | 6 | 5 | 7 | 0 | 83.3% | 1.17 | 1.40 | 19 | 0 | 31 |
| 23 | Kimani VidalLos Angeles Chargers·#30 | 10 | 26 | 61 | 2.35 | 2 | 33 | 6 | 7 | 6 | 3 | 16 | 1 | 50.0% | 2.67 | 5.33 | 17 | 0 | 71 |
| 24 | Chuba HubbardCarolina Panthers·#30 | 14 | 19 | 47 | 2.47 | 1 | 39 | 6 | 2 | 6 | 4 | 5 | 1 | 66.7% | 0.83 | 1.25 | 15 | 0 | 60 |
| 25 | Alvin KamaraNew Orleans Saints·#41 | 10 | 15 | 58 | 3.87 | 1 | 34 | 3 | 2 | 5 | 4 | 5 | 0 | 80.0% | 1.00 | 1.25 | 5 | 0 | 55 |
| 26 | Aaron JonesMinnesota Vikings·#33 | 11 | 14 | 44 | 3.14 | 2 | 30 | 3 | 3 | 5 | 3 | 11 | 0 | 60.0% | 2.20 | 3.67 | 13 | 0 | 48 |
| 27 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 71 | 206 | 2.90 | 14 | 130 | 22 | 24 | 5 | 4 | 33 | 2 | 80.0% | 6.60 | 8.25 | 40 | 0 | 147 |
| 28 | Tyrone Tracy Jr.New York Giants·#29 | 12 | 21 | 68 | 3.24 | 1 | 43 | 4 | 2 | 5 | 4 | 32 | 2 | 80.0% | 6.40 | 8.00 | 6 | 0 | 62 |
| 29 | Rico DowdleCarolina Panthers·#5 | 14 | 35 | 78 | 2.23 | 6 | 48 | 8 | 9 | 5 | 3 | 13 | 0 | 60.0% | 2.60 | 4.33 | 24 | 1 | 77 |
| 30 | Ray DavisBuffalo Bills·#22 | 10 | 7 | 21 | 3.00 | 0 | 17 | 1 | 2 | 5 | 4 | 17 | 2 | 80.0% | 3.40 | 4.25 | 29 | 0 | 27 |
| 31 | Jaylen WarrenPittsburgh Steelers·#30 | 14 | 40 | 89 | 2.22 | 4 | 52 | 9 | 14 | 5 | 4 | 20 | 1 | 80.0% | 4.00 | 5.00 | 27 | 1 | 81 |
| 32 | Isiah PachecoKansas City Chiefs·#10 | 12 | 20 | 60 | 3.00 | 1 | 36 | 4 | 0 | 4 | 2 | 13 | 1 | 50.0% | 3.25 | 6.50 | 12 | 0 | 55 |
| 33 | Cam SkatteboNew York Giants·#44 | 8 | 24 | 67 | 2.79 | 5 | 52 | 6 | 10 | 4 | 3 | 32 | 2 | 75.0% | 8.00 | 10.67 | 29 | 1 | 51 |
| 34 | Bucky IrvingTampa Bay Buccaneers·#7 | 9 | 18 | 55 | 3.06 | 1 | 42 | 3 | 0 | 4 | 3 | 11 | 1 | 75.0% | 2.75 | 3.67 | 17 | 0 | 37 |
| 35 | TreVeyon HendersonNew England Patriots·#32 | 16 | 35 | 87 | 2.49 | 5 | 53 | 8 | 8 | 4 | 4 | 13 | 1 | 100.0% | 3.25 | 3.25 | 15 | 1 | 71 |
| 36 | Ty JohnsonBuffalo Bills·#26 | 16 | 19 | 74 | 3.89 | 3 | 51 | 6 | 6 | 4 | 2 | 13 | 1 | 50.0% | 3.25 | 6.50 | 16 | 0 | 57 |
| 37 | Brian RobinsonSan Francisco 49ers·#3 | 11 | 13 | 46 | 3.54 | 2 | 47 | 3 | 2 | 4 | 3 | 12 | 0 | 75.0% | 3.00 | 4.00 | 12 | 0 | 30 |
| 38 | Kareem HuntKansas City Chiefs·#29 | 16 | 38 | 89 | 2.34 | 8 | 53 | 16 | 15 | 4 | 2 | 13 | 1 | 50.0% | 3.25 | 6.50 | 15 | 1 | 94 |
| 39 | Zach CharbonnetSeattle Seahawks·#26 | 15 | 50 | 124 | 2.48 | 11 | 91 | 17 | 18 | 3 | 3 | 7 | 0 | 100.0% | 2.33 | 2.33 | 8 | 0 | 91 |
| 40 | Kyle MonangaiChicago Bears·#25 | 17 | 37 | 102 | 2.76 | 5 | 41 | 9 | 12 | 3 | 2 | 1 | 0 | 66.7% | 0.33 | 0.50 | 6 | 0 | 76 |
| 41 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 34 | 111 | 3.26 | 4 | 57 | 9 | 8 | 3 | 2 | 7 | 0 | 66.7% | 2.33 | 3.50 | 12 | 1 | 66 |
| 42 | Sean TuckerTampa Bay Buccaneers·#44 | 10 | 21 | 61 | 2.90 | 6 | 37 | 8 | 11 | 3 | 1 | -4 | 0 | 33.3% | -1.33 | -4.00 | 3 | 0 | 33 |
| 43 | Emanuel WilsonGreen Bay Packers·#23 | 13 | 24 | 84 | 3.50 | 3 | 47 | 7 | 4 | 3 | 1 | 1 | 0 | 33.3% | 0.33 | 1.00 | 4 | 0 | 48 |
| 44 | Jeremy McNicholsWashington Commanders·#26 | 15 | 6 | 39 | 6.50 | 0 | 24 | 2 | 2 | 3 | 2 | 6 | 0 | 66.7% | 2.00 | 3.00 | 10 | 0 | 42 |
| 45 | James CookBuffalo Bills·#4 | 16 | 56 | 155 | 2.77 | 7 | 84 | 11 | 16 | 3 | 3 | 10 | 1 | 100.0% | 3.33 | 3.33 | 15 | 1 | 96 |
| 46 | Dare OgunbowaleHouston Texans·#33 | 9 | 6 | 12 | 2.00 | 1 | 11 | 1 | 3 | 3 | 2 | 14 | 0 | 66.7% | 4.67 | 7.00 | 2 | 0 | 26 |
| 47 | Bhayshul TutenJacksonville Jaguars·#33 | 13 | 26 | 75 | 2.88 | 5 | 53 | 10 | 8 | 2 | 2 | 24 | 2 | 100.0% | 12.00 | 12.00 | 16 | 0 | 48 |
| 48 | David MontgomeryDetroit Lions·#5 | 15 | 35 | 75 | 2.14 | 6 | 49 | 10 | 17 | 2 | 1 | 7 | 0 | 50.0% | 3.50 | 7.00 | 3 | 0 | 79 |
| 49 | Isaiah DavisNew York Jets·#32 | 13 | 9 | 30 | 3.33 | 0 | 17 | 2 | 0 | 2 | 1 | 11 | 0 | 50.0% | 5.50 | 11.00 | 5 | 0 | 27 |
| 50 | Derrick HenryBaltimore Ravens·#22 | 15 | 63 | 158 | 2.51 | 10 | 94 | 16 | 27 | 2 | 2 | 13 | 0 | 100.0% | 6.50 | 6.50 | 8 | 0 | 103 |