| 1 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 27 | 116 | 4.30 | 2 | 83 | 9 | 2 | 27 | 20 | 181 | 1 | 74.1% | 6.70 | 9.05 | 136 | 6 | 5 | 1 | 2 | 150 |
| 2 | Jahmyr GibbsDetroit Lions·#0 | 16 | 13 | 36 | 2.77 | 1 | 33 | 4 | 0 | 20 | 18 | 113 | 1 | 90.0% | 5.65 | 6.28 | 77 | 3 | 3 | 1 | 0 | 116 |
| 3 | Kenneth GainwellPittsburgh Steelers·#14 | 16 | 21 | 132 | 6.29 | 0 | 79 | 6 | 1 | 16 | 15 | 159 | 1 | 93.8% | 9.94 | 10.60 | 139 | 4 | 3 | 0 | 0 | 124 |
| 4 | De'Von AchaneMiami Dolphins·#28 | 14 | 28 | 144 | 5.14 | 0 | 80 | 4 | 2 | 15 | 12 | 140 | 1 | 80.0% | 9.33 | 11.67 | 131 | 3 | 1 | 0 | 0 | 103 |
| 5 | Chase BrownCincinnati Bengals·#30 | 17 | 23 | 120 | 5.22 | 0 | 75 | 9 | 2 | 15 | 11 | 84 | 1 | 73.3% | 5.60 | 7.64 | 70 | 2 | 2 | 1 | 1 | 96 |
| 6 | Woody MarksHouston Texans·#27 | 15 | 27 | 90 | 3.33 | 1 | 71 | 6 | 3 | 14 | 9 | 21 | 1 | 64.3% | 1.50 | 2.33 | 32 | 2 | 1 | 1 | 0 | 101 |
| 7 | Tyler BadieDenver Broncos·#28 | 14 | 1 | 7 | 7.00 | 0 | 11 | 0 | 0 | 13 | 9 | 51 | 0 | 69.2% | 3.92 | 5.67 | 73 | 1 | 1 | 0 | 0 | 64 |
| 8 | Bijan RobinsonAtlanta Falcons·#7 | 16 | 27 | 188 | 6.96 | 1 | 167 | 5 | 2 | 12 | 7 | 46 | 0 | 58.3% | 3.83 | 6.57 | 58 | 0 | 0 | 0 | 1 | 138 |
| 9 | Michael CarterArizona Cardinals·#22 | 10 | 6 | 36 | 6.00 | 0 | 42 | 3 | 0 | 11 | 8 | 81 | 0 | 72.7% | 7.36 | 10.12 | 64 | 2 | 1 | 0 | 0 | 66 |
| 10 | Alvin KamaraNew Orleans Saints·#41 | 10 | 5 | 10 | 2.00 | 0 | 17 | 0 | 0 | 11 | 10 | 57 | 0 | 90.9% | 5.18 | 5.70 | 42 | 1 | 1 | 0 | 1 | 75 |
| 11 | Rico DowdleCarolina Panthers·#5 | 14 | 27 | 142 | 5.26 | 1 | 88 | 8 | 1 | 11 | 8 | 77 | 0 | 72.7% | 7.00 | 9.62 | 81 | 1 | 0 | 0 | 2 | 85 |
| 12 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 20 | 50 | 2.50 | 0 | 58 | 1 | 0 | 11 | 10 | 59 | 0 | 90.9% | 5.36 | 5.90 | 88 | 1 | 1 | 0 | 0 | 66 |
| 13 | Tyjae SpearsTennessee Titans·#2 | 13 | 20 | 85 | 4.25 | 1 | 61 | 7 | 1 | 10 | 8 | 27 | 0 | 80.0% | 2.70 | 3.38 | 50 | 1 | 1 | 0 | 0 | 83 |
| 14 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 37 | 135 | 3.65 | 2 | 88 | 8 | 4 | 10 | 8 | 49 | 0 | 80.0% | 4.90 | 6.12 | 48 | 4 | 3 | 0 | 0 | 99 |
| 15 | D'Andre SwiftChicago Bears·#4 | 15 | 24 | 116 | 4.83 | 1 | 70 | 7 | 1 | 10 | 7 | 38 | 0 | 70.0% | 3.80 | 5.43 | 47 | 1 | 1 | 0 | 1 | 104 |
| 16 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 38 | 143 | 3.76 | 0 | 142 | 5 | 1 | 10 | 8 | 37 | 1 | 80.0% | 3.70 | 4.62 | 43 | 2 | 2 | 1 | 0 | 114 |
| 17 | Zavier ScottMinnesota Vikings·#36 | 6 | 6 | 47 | 7.83 | 0 | 31 | 3 | 0 | 10 | 9 | 59 | 0 | 90.0% | 5.90 | 6.56 | 74 | 1 | 1 | 0 | 0 | 27 |
| 18 | Tyrone Tracy Jr.New York Giants·#29 | 13 | 8 | 22 | 2.75 | 0 | 23 | 1 | 0 | 9 | 6 | 19 | 0 | 66.7% | 2.11 | 3.17 | 29 | 2 | 1 | 0 | 1 | 88 |
| 19 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 13 | 57 | 4.38 | 2 | 51 | 3 | 2 | 9 | 8 | 71 | 0 | 88.9% | 7.89 | 8.88 | 92 | 3 | 3 | 0 | 3 | 97 |
| 20 | Jeremy McNicholsWashington Commanders·#26 | 16 | 12 | 57 | 4.75 | 0 | 41 | 5 | 1 | 8 | 7 | 40 | 0 | 87.5% | 5.00 | 5.71 | 53 | 0 | 0 | 0 | 0 | 86 |
| 21 | Isaiah DavisNew York Jets·#32 | 15 | 6 | 38 | 6.33 | 0 | 23 | 1 | 0 | 8 | 5 | 45 | 0 | 62.5% | 5.62 | 9.00 | 25 | 0 | 0 | 0 | 1 | 73 |
| 22 | Justice HillBaltimore Ravens·#43 | 10 | 3 | 62 | 20.67 | 1 | 62 | 1 | 0 | 8 | 7 | 80 | 0 | 87.5% | 10.00 | 11.43 | 64 | 0 | 0 | 0 | 1 | 46 |
| 23 | Tony PollardTennessee Titans·#20 | 16 | 26 | 93 | 3.58 | 0 | 74 | 4 | 0 | 8 | 6 | 18 | 0 | 75.0% | 2.25 | 3.00 | 25 | 0 | 0 | 0 | 3 | 79 |
| 24 | Josh JacobsGreen Bay Packers·#8 | 14 | 27 | 94 | 3.48 | 2 | 77 | 8 | 3 | 8 | 7 | 58 | 0 | 87.5% | 7.25 | 8.29 | 62 | 1 | 1 | 0 | 3 | 72 |
| 25 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 44 | 213 | 4.84 | 2 | 118 | 16 | 5 | 8 | 5 | 52 | 1 | 62.5% | 6.50 | 10.40 | 39 | 1 | 1 | 1 | 2 | 133 |
| 26 | Dylan SampsonCleveland Browns·#22 | 11 | 9 | 10 | 1.11 | 0 | 28 | 0 | 0 | 8 | 6 | 72 | 1 | 75.0% | 9.00 | 12.00 | 52 | 2 | 1 | 1 | 0 | 38 |
| 27 | Aaron JonesMinnesota Vikings·#33 | 11 | 16 | 51 | 3.19 | 0 | 38 | 3 | 0 | 7 | 4 | 27 | 0 | 57.1% | 3.86 | 6.75 | 23 | 1 | 1 | 0 | 1 | 59 |
| 28 | Raheem MostertLas Vegas Raiders·#31 | 9 | 7 | 24 | 3.43 | 0 | 16 | 2 | 0 | 7 | 7 | 46 | 0 | 100.0% | 6.57 | 6.57 | 48 | 0 | 0 | 0 | 1 | 50 |
| 29 | Cam SkatteboNew York Giants·#44 | 6 | 13 | 45 | 3.46 | 2 | 36 | 3 | 1 | 7 | 4 | 46 | 0 | 57.1% | 6.57 | 11.50 | 47 | 1 | 1 | 0 | 0 | 38 |
| 30 | Travis EtienneJacksonville Jaguars·#1 | 15 | 17 | 61 | 3.59 | 1 | 49 | 3 | 0 | 7 | 7 | 52 | 1 | 100.0% | 7.43 | 7.43 | 41 | 2 | 2 | 1 | 0 | 57 |
| 31 | Rhamondre StevensonNew England Patriots·#38 | 14 | 16 | 75 | 4.69 | 1 | 53 | 3 | 0 | 6 | 5 | 55 | 0 | 83.3% | 9.17 | 11.00 | 49 | 1 | 1 | 0 | 1 | 89 |
| 32 | Ashton JeantyLas Vegas Raiders·#2 | 13 | 16 | 46 | 2.88 | 0 | 32 | 0 | 2 | 6 | 4 | 5 | 0 | 66.7% | 0.83 | 1.25 | 10 | 0 | 0 | 0 | 0 | 57 |
| 33 | Chuba HubbardCarolina Panthers·#30 | 12 | 15 | 54 | 3.60 | 0 | 34 | 0 | 0 | 5 | 2 | 33 | 0 | 40.0% | 6.60 | 16.50 | 45 | 1 | 0 | 0 | 1 | 65 |
| 34 | Jerome FordCleveland Browns·#34 | 12 | 7 | 34 | 4.86 | 0 | 24 | 3 | 0 | 5 | 4 | 19 | 0 | 80.0% | 3.80 | 4.75 | 34 | 2 | 2 | 0 | 0 | 74 |
| 35 | Rasheen AliBaltimore Ravens·#26 | 6 | 3 | 17 | 5.67 | 0 | 8 | 1 | 0 | 5 | 4 | 13 | 0 | 80.0% | 2.60 | 3.25 | 24 | 0 | 0 | 0 | 2 | 33 |
| 36 | Kareem HuntKansas City Chiefs·#29 | 15 | 23 | 97 | 4.22 | 1 | 65 | 7 | 5 | 5 | 5 | 48 | 0 | 100.0% | 9.60 | 9.60 | 52 | 0 | 0 | 0 | 0 | 89 |
| 37 | TreVeyon HendersonNew England Patriots·#32 | 12 | 19 | 122 | 6.42 | 1 | 40 | 4 | 2 | 5 | 3 | 26 | 0 | 60.0% | 5.20 | 8.67 | 23 | 0 | 0 | 0 | 1 | 56 |
| 38 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 33 | 118 | 3.58 | 2 | 91 | 10 | 3 | 5 | 4 | 35 | 0 | 80.0% | 7.00 | 8.75 | 24 | 0 | 0 | 0 | 1 | 110 |
| 39 | RJ HarveyDenver Broncos·#12 | 12 | 14 | 56 | 4.00 | 0 | 29 | 4 | 2 | 5 | 5 | 16 | 1 | 100.0% | 3.20 | 3.20 | 25 | 1 | 1 | 1 | 0 | 44 |
| 40 | Audric EstiméNew Orleans Saints·#30 | 4 | 3 | 2 | 0.67 | 0 | 10 | 1 | 0 | 4 | 4 | 38 | 0 | 100.0% | 9.50 | 9.50 | 37 | 0 | 0 | 0 | 0 | 32 |
| 41 | Breece HallNew York Jets·#20 | 16 | 21 | 53 | 2.52 | 0 | 24 | 4 | 0 | 4 | 3 | 17 | 0 | 75.0% | 4.25 | 5.67 | 7 | 0 | 0 | 0 | 1 | 81 |
| 42 | Omarion HamptonLos Angeles Chargers·#8 | 7 | 12 | 42 | 3.50 | 1 | 24 | 3 | 1 | 4 | 3 | -7 | 0 | 75.0% | -1.75 | -2.33 | 2 | 0 | 0 | 0 | 0 | 44 |
| 43 | Ty JohnsonBuffalo Bills·#26 | 14 | 7 | 22 | 3.14 | 0 | 15 | 2 | 0 | 4 | 3 | 60 | 1 | 75.0% | 15.00 | 20.00 | 69 | 0 | 0 | 0 | 0 | 53 |
| 44 | Isiah PachecoKansas City Chiefs·#10 | 11 | 3 | 6 | 2.00 | 0 | 8 | 1 | 0 | 4 | 4 | 11 | 1 | 100.0% | 2.75 | 2.75 | 18 | 1 | 1 | 1 | 0 | 55 |
| 45 | Devin NealNew Orleans Saints·#24 | 5 | 6 | 9 | 1.50 | 0 | 8 | 1 | 0 | 4 | 3 | 29 | 0 | 75.0% | 7.25 | 9.67 | 23 | 0 | 0 | 0 | 0 | 58 |
| 46 | Bam KnightArizona Cardinals·#20 | 7 | 7 | 8 | 1.14 | 0 | 8 | 1 | 1 | 4 | 4 | 22 | 0 | 100.0% | 5.50 | 5.50 | 23 | 0 | 0 | 0 | 0 | 25 |
| 47 | Dare OgunbowaleHouston Texans·#33 | 11 | 1 | 4 | 4.00 | 0 | 3 | 0 | 0 | 4 | 4 | 43 | 0 | 100.0% | 10.75 | 10.75 | 41 | 0 | 0 | 0 | 1 | 25 |
| 48 | Chris BrooksGreen Bay Packers·#30 | 10 | 4 | 21 | 5.25 | 0 | 18 | 1 | 0 | 4 | 3 | 33 | 0 | 75.0% | 8.25 | 11.00 | 38 | 0 | 0 | 0 | 0 | 31 |
| 49 | J.K. DobbinsDenver Broncos·#27 | 8 | 13 | 48 | 3.69 | 0 | 42 | 3 | 0 | 4 | 4 | 9 | 0 | 100.0% | 2.25 | 2.25 | 20 | 0 | 0 | 0 | 0 | 33 |
| 50 | Javonte WilliamsDallas Cowboys·#33 | 13 | 16 | 165 | 10.31 | 1 | 102 | 7 | 2 | 4 | 3 | 20 | 0 | 75.0% | 5.00 | 6.67 | 14 | 0 | 0 | 0 | 0 | 98 |