| 1 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 95 | 455 | 4.79 | 2 | 305 | 21 | 4 | 25 | 18 | 202 | 2 | 72.0% | 8.08 | 11.22 | 215 | 3 | 2 | 1 | 1 | 216 |
| 2 | Christian McCaffreySan Francisco 49ers·#23 | 15 | 80 | 352 | 4.40 | 3 | 236 | 23 | 7 | 31 | 25 | 195 | 1 | 80.7% | 6.29 | 7.80 | 146 | 4 | 2 | 1 | 0 | 219 |
| 3 | Jonathan TaylorIndianapolis Colts·#28 | 15 | 61 | 280 | 4.59 | 3 | 202 | 17 | 5 | 10 | 9 | 76 | 0 | 90.0% | 7.60 | 8.44 | 82 | 0 | 0 | 0 | 0 | 157 |
| 4 | James CookBuffalo Bills·#4 | 15 | 60 | 322 | 5.37 | 4 | 200 | 18 | 3 | 7 | 6 | 33 | 0 | 85.7% | 4.71 | 5.50 | 30 | 0 | 0 | 0 | 4 | 115 |
| 5 | Jaylen WarrenPittsburgh Steelers·#30 | 13 | 49 | 242 | 4.94 | 2 | 198 | 14 | 4 | 12 | 11 | 111 | 0 | 91.7% | 9.25 | 10.09 | 139 | 1 | 1 | 0 | 1 | 98 |
| 6 | Travis EtienneJacksonville Jaguars·#1 | 16 | 75 | 317 | 4.23 | 2 | 196 | 15 | 4 | 12 | 9 | 55 | 2 | 75.0% | 4.58 | 6.11 | 80 | 3 | 3 | 2 | 0 | 185 |
| 7 | Josh JacobsGreen Bay Packers·#8 | 12 | 72 | 259 | 3.60 | 1 | 190 | 17 | 3 | 13 | 12 | 67 | 0 | 92.3% | 5.15 | 5.58 | 97 | 1 | 1 | 0 | 2 | 151 |
| 8 | Javonte WilliamsDallas Cowboys·#33 | 16 | 65 | 292 | 4.49 | 4 | 189 | 18 | 7 | 12 | 7 | 15 | 0 | 58.3% | 1.25 | 2.14 | 33 | 1 | 1 | 0 | 2 | 147 |
| 9 | Derrick HenryBaltimore Ravens·#22 | 12 | 67 | 328 | 4.90 | 3 | 170 | 18 | 6 | 3 | 3 | 25 | 0 | 100.0% | 8.33 | 8.33 | 22 | 0 | 0 | 0 | 0 | 112 |
| 10 | Tony PollardTennessee Titans·#20 | 15 | 60 | 259 | 4.32 | 0 | 169 | 12 | 0 | 7 | 5 | 44 | 0 | 71.4% | 6.29 | 8.80 | 60 | 1 | 1 | 0 | 1 | 135 |
| 11 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 56 | 265 | 4.73 | 4 | 165 | 17 | 7 | 18 | 11 | 86 | 0 | 61.1% | 4.78 | 7.82 | 38 | 4 | 2 | 0 | 0 | 178 |
| 12 | Ashton JeantyLas Vegas Raiders·#2 | 15 | 62 | 203 | 3.27 | 1 | 157 | 9 | 3 | 18 | 14 | 74 | 0 | 77.8% | 4.11 | 5.29 | 100 | 3 | 2 | 0 | 0 | 173 |
| 13 | D'Andre SwiftChicago Bears·#4 | 15 | 48 | 208 | 4.33 | 2 | 148 | 12 | 1 | 12 | 9 | 71 | 0 | 75.0% | 5.92 | 7.89 | 104 | 0 | 0 | 0 | 1 | 110 |
| 14 | Rhamondre StevensonNew England Patriots·#38 | 10 | 29 | 184 | 6.34 | 0 | 140 | 6 | 1 | 6 | 5 | 58 | 0 | 83.3% | 9.67 | 11.60 | 33 | 1 | 1 | 0 | 3 | 83 |
| 15 | Chase BrownCincinnati Bengals·#30 | 13 | 49 | 209 | 4.27 | 2 | 139 | 11 | 3 | 8 | 7 | 31 | 1 | 87.5% | 3.88 | 4.43 | 34 | 1 | 1 | 1 | 0 | 112 |
| 16 | Jahmyr GibbsDetroit Lions·#0 | 15 | 61 | 290 | 4.75 | 5 | 138 | 15 | 6 | 22 | 18 | 157 | 1 | 81.8% | 7.14 | 8.72 | 154 | 4 | 3 | 1 | 0 | 156 |
| 17 | De'Von AchaneMiami Dolphins·#28 | 14 | 56 | 378 | 6.75 | 1 | 138 | 15 | 2 | 15 | 13 | 97 | 1 | 86.7% | 6.47 | 7.46 | 93 | 1 | 1 | 1 | 0 | 121 |
| 18 | Aaron JonesMinnesota Vikings·#33 | 11 | 50 | 221 | 4.42 | 2 | 135 | 15 | 3 | 17 | 12 | 56 | 0 | 70.6% | 3.29 | 4.67 | 65 | 3 | 2 | 0 | 0 | 120 |
| 19 | Quinshon JudkinsCleveland Browns·#10 | 11 | 55 | 231 | 4.20 | 3 | 128 | 13 | 3 | 9 | 5 | 18 | 0 | 55.6% | 2.00 | 3.60 | 23 | 0 | 0 | 0 | 0 | 107 |
| 20 | David MontgomeryDetroit Lions·#5 | 10 | 29 | 186 | 6.41 | 2 | 119 | 9 | 2 | 1 | 1 | 13 | 0 | 100.0% | 13.00 | 13.00 | 9 | 0 | 0 | 0 | 1 | 58 |
| 21 | Rico DowdleCarolina Panthers·#5 | 11 | 51 | 211 | 4.14 | 2 | 116 | 10 | 2 | 13 | 10 | 38 | 0 | 76.9% | 2.92 | 3.80 | 56 | 3 | 2 | 0 | 1 | 123 |
| 22 | RJ HarveyDenver Broncos·#12 | 12 | 45 | 160 | 3.56 | 1 | 109 | 13 | 2 | 16 | 14 | 76 | 1 | 87.5% | 4.75 | 5.43 | 96 | 3 | 3 | 1 | 1 | 128 |
| 23 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 54 | 195 | 3.61 | 0 | 105 | 8 | 1 | 10 | 10 | 133 | 0 | 100.0% | 13.30 | 13.30 | 159 | 0 | 0 | 0 | 0 | 113 |
| 24 | Rachaad WhiteTampa Bay Buccaneers·#1 | 13 | 37 | 136 | 3.68 | 2 | 103 | 14 | 6 | 7 | 6 | 27 | 0 | 85.7% | 3.86 | 4.50 | 42 | 1 | 1 | 0 | 0 | 103 |
| 25 | Zach CharbonnetSeattle Seahawks·#26 | 14 | 28 | 157 | 5.61 | 4 | 101 | 12 | 4 | 3 | 3 | 25 | 0 | 100.0% | 8.33 | 8.33 | 20 | 0 | 0 | 0 | 0 | 85 |
| 26 | Breece HallNew York Jets·#20 | 11 | 65 | 247 | 3.80 | 1 | 94 | 16 | 2 | 8 | 6 | 82 | 1 | 75.0% | 10.25 | 13.67 | 85 | 2 | 0 | 0 | 0 | 129 |
| 27 | Saquon BarkleyPhiladelphia Eagles·#26 | 13 | 52 | 250 | 4.81 | 2 | 93 | 7 | 4 | 12 | 11 | 38 | 1 | 91.7% | 3.17 | 3.45 | 61 | 2 | 2 | 1 | 2 | 137 |
| 28 | Jeremy McNicholsWashington Commanders·#26 | 8 | 8 | 70 | 8.75 | 1 | 85 | 1 | 1 | 2 | 2 | 32 | 0 | 100.0% | 16.00 | 16.00 | 22 | 0 | 0 | 0 | 0 | 39 |
| 29 | Woody MarksHouston Texans·#27 | 15 | 40 | 119 | 2.98 | 0 | 85 | 4 | 1 | 3 | 1 | 37 | 0 | 33.3% | 12.33 | 37.00 | 32 | 0 | 0 | 0 | 0 | 99 |
| 30 | Bucky IrvingTampa Bay Buccaneers·#7 | 8 | 38 | 125 | 3.29 | 0 | 80 | 7 | 0 | 6 | 5 | 25 | 1 | 83.3% | 4.17 | 5.00 | 39 | 1 | 1 | 1 | 0 | 79 |
| 31 | Nick ChubbHouston Texans·#21 | 12 | 30 | 97 | 3.23 | 0 | 76 | 2 | 1 | 6 | 5 | 42 | 0 | 83.3% | 7.00 | 8.40 | 44 | 0 | 0 | 0 | 1 | 78 |
| 32 | Kimani VidalLos Angeles Chargers·#30 | 9 | 25 | 99 | 3.96 | 1 | 74 | 4 | 0 | 3 | 3 | 77 | 0 | 100.0% | 25.67 | 25.67 | 83 | 0 | 0 | 0 | 0 | 73 |
| 33 | Isiah PachecoKansas City Chiefs·#10 | 10 | 27 | 106 | 3.93 | 0 | 71 | 7 | 0 | 5 | 5 | 20 | 0 | 100.0% | 4.00 | 4.00 | 38 | 0 | 0 | 0 | 0 | 87 |
| 34 | Tyrone Tracy Jr.New York Giants·#29 | 10 | 28 | 74 | 2.64 | 0 | 64 | 5 | 0 | 7 | 6 | 30 | 0 | 85.7% | 4.29 | 5.00 | 40 | 0 | 0 | 0 | 0 | 83 |
| 35 | Brian RobinsonSan Francisco 49ers·#3 | 10 | 17 | 106 | 6.24 | 0 | 63 | 6 | 1 | 4 | 2 | 10 | 0 | 50.0% | 2.50 | 5.00 | 21 | 1 | 1 | 0 | 0 | 34 |
| 36 | Chuba HubbardCarolina Panthers·#30 | 11 | 28 | 93 | 3.32 | 0 | 63 | 8 | 0 | 6 | 5 | 45 | 0 | 83.3% | 7.50 | 9.00 | 57 | 0 | 0 | 0 | 1 | 79 |
| 37 | Chris Rodriguez Jr.Washington Commanders·#36 | 7 | 23 | 113 | 4.91 | 0 | 63 | 6 | 4 | 2 | 2 | 24 | 0 | 100.0% | 12.00 | 12.00 | 20 | 0 | 0 | 0 | 0 | 38 |
| 38 | Kareem HuntKansas City Chiefs·#29 | 14 | 31 | 124 | 4.00 | 1 | 61 | 10 | 3 | 4 | 3 | 10 | 1 | 75.0% | 2.50 | 3.33 | 5 | 1 | 1 | 1 | 0 | 100 |
| 39 | Kyle MonangaiChicago Bears·#25 | 14 | 26 | 128 | 4.92 | 1 | 60 | 8 | 2 | 8 | 4 | 24 | 0 | 50.0% | 3.00 | 6.00 | 15 | 2 | 1 | 0 | 0 | 69 |
| 40 | Bam KnightArizona Cardinals·#20 | 6 | 23 | 96 | 4.17 | 0 | 60 | 4 | 0 | 2 | 1 | 5 | 0 | 50.0% | 2.50 | 5.00 | 5 | 1 | 1 | 0 | 0 | 64 |
| 41 | J.K. DobbinsDenver Broncos·#27 | 8 | 30 | 119 | 3.97 | 0 | 53 | 5 | 0 | 3 | 3 | 3 | 0 | 100.0% | 1.00 | 1.00 | 14 | 0 | 0 | 0 | 1 | 51 |
| 42 | TreVeyon HendersonNew England Patriots·#32 | 14 | 26 | 123 | 4.73 | 2 | 52 | 7 | 1 | 8 | 8 | 56 | 0 | 100.0% | 7.00 | 7.00 | 50 | 1 | 1 | 0 | 0 | 78 |
| 43 | Sean TuckerTampa Bay Buccaneers·#44 | 9 | 18 | 67 | 3.72 | 1 | 50 | 8 | 3 | 3 | 2 | -1 | 0 | 66.7% | -0.33 | -0.50 | 8 | 2 | 1 | 0 | 0 | 40 |
| 44 | James ConnerArizona Cardinals·#6 | 2 | 13 | 36 | 2.77 | 0 | 48 | 3 | 0 | 6 | 5 | 16 | 1 | 83.3% | 2.67 | 3.20 | 38 | 1 | 1 | 1 | 0 | 38 |
| 45 | Tank BigsbyPhiladelphia Eagles·#37 | 6 | 11 | 61 | 5.55 | 0 | 47 | 3 | 0 | 1 | 1 | 31 | 0 | 100.0% | 31.00 | 31.00 | 30 | 0 | 0 | 0 | 0 | 33 |
| 46 | Tyler AllgeierAtlanta Falcons·#25 | 12 | 25 | 84 | 3.36 | 1 | 44 | 5 | 0 | 5 | 5 | 48 | 0 | 100.0% | 9.60 | 9.60 | 60 | 0 | 0 | 0 | 1 | 55 |
| 47 | Omarion HamptonLos Angeles Chargers·#8 | 7 | 18 | 89 | 4.94 | 0 | 43 | 5 | 0 | 3 | 2 | 12 | 1 | 66.7% | 4.00 | 6.00 | 17 | 1 | 1 | 1 | 0 | 51 |
| 48 | Alvin KamaraNew Orleans Saints·#41 | 9 | 17 | 77 | 4.53 | 0 | 43 | 2 | 0 | 2 | 1 | 9 | 0 | 50.0% | 4.50 | 9.00 | 7 | 0 | 0 | 0 | 3 | 42 |
| 49 | Samaje PerineCincinnati Bengals·#34 | 12 | 13 | 48 | 3.69 | 0 | 38 | 5 | 0 | 7 | 6 | 30 | 0 | 85.7% | 4.29 | 5.00 | 36 | 0 | 0 | 0 | 0 | 47 |
| 50 | Bhayshul TutenJacksonville Jaguars·#33 | 8 | 16 | 65 | 4.06 | 1 | 38 | 3 | 2 | 4 | 2 | 5 | 1 | 50.0% | 1.25 | 2.50 | 16 | 1 | 1 | 1 | 0 | 36 |