| 1 | Emari DemercadoArizona Cardinals·#31 | 11 | 44 | 312 | 7.09 | 0 | 133 | 9 | 0 | 20 | 13 | 101 | 1 | 65.0% | 5.05 | 7.77 | 84 | 4 | 3 | 1 | 3 | 177 |
| 2 | Miles SandersDallas Cowboys·#24 | 4 | 20 | 117 | 5.85 | 1 | 75 | 6 | 1 | 8 | 8 | 30 | 0 | 100.0% | 3.75 | 3.75 | 44 | 1 | 1 | 0 | 1 | 58 |
| 3 | Keaton MitchellBaltimore Ravens·#34 | 13 | 59 | 341 | 5.78 | 1 | 172 | 16 | 0 | 12 | 9 | 63 | 0 | 75.0% | 5.25 | 7.00 | 85 | 0 | 0 | 0 | 1 | 116 |
| 4 | De'Von AchaneMiami Dolphins·#28 | 16 | 238 | 1,350 | 5.67 | 8 | 817 | 57 | 5 | 84 | 67 | 481 | 4 | 79.8% | 5.73 | 7.18 | 545 | 11 | 7 | 3 | 3 | 644 |
| 5 | Isaiah DavisNew York Jets·#32 | 16 | 42 | 237 | 5.64 | 1 | 165 | 9 | 0 | 29 | 21 | 188 | 0 | 72.4% | 6.48 | 8.95 | 189 | 2 | 1 | 0 | 2 | 260 |
| 6 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 55 | 306 | 5.56 | 1 | 219 | 16 | 6 | 4 | 3 | 32 | 0 | 75.0% | 8.00 | 10.67 | 39 | 1 | 1 | 0 | 0 | 114 |
| 7 | Trey BensonArizona Cardinals·#33 | 4 | 29 | 160 | 5.52 | 0 | 157 | 4 | 1 | 16 | 13 | 64 | 0 | 81.3% | 4.00 | 4.92 | 73 | 2 | 1 | 0 | 1 | 113 |
| 8 | Trayveon WilliamsCleveland Browns·#38 | 4 | 7 | 37 | 5.29 | 0 | 34 | 3 | 0 | 8 | 7 | 55 | 0 | 87.5% | 6.88 | 7.86 | 82 | 2 | 2 | 0 | 0 | 60 |
| 9 | Jeremy McNicholsWashington Commanders·#26 | 17 | 44 | 232 | 5.27 | 1 | 229 | 13 | 2 | 32 | 25 | 196 | 0 | 78.1% | 6.12 | 7.84 | 222 | 3 | 2 | 0 | 2 | 287 |
| 10 | James CookBuffalo Bills·#4 | 17 | 308 | 1,612 | 5.23 | 12 | 1,020 | 69 | 16 | 40 | 33 | 291 | 2 | 82.5% | 7.28 | 8.82 | 272 | 3 | 3 | 1 | 5 | 594 |
| 11 | Derrick HenryBaltimore Ravens·#22 | 17 | 307 | 1,595 | 5.20 | 16 | 916 | 80 | 27 | 20 | 15 | 150 | 0 | 75.0% | 7.50 | 10.00 | 135 | 2 | 2 | 0 | 4 | 528 |
| 12 | Justice HillBaltimore Ravens·#43 | 10 | 18 | 93 | 5.17 | 2 | 108 | 4 | 1 | 27 | 21 | 169 | 1 | 77.8% | 6.26 | 8.05 | 184 | 1 | 1 | 1 | 2 | 190 |
| 13 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 287 | 1,474 | 5.14 | 7 | 1,090 | 64 | 11 | 103 | 79 | 820 | 4 | 76.7% | 7.96 | 10.38 | 857 | 13 | 9 | 3 | 6 | 804 |
| 14 | Blake CorumLos Angeles Rams·#22 | 17 | 145 | 746 | 5.14 | 6 | 346 | 45 | 13 | 14 | 8 | 36 | 0 | 57.1% | 2.57 | 4.50 | 37 | 1 | 0 | 0 | 1 | 308 |
| 15 | TreVeyon HendersonNew England Patriots·#32 | 17 | 178 | 902 | 5.07 | 9 | 367 | 44 | 8 | 42 | 35 | 221 | 1 | 83.3% | 5.26 | 6.31 | 244 | 4 | 4 | 1 | 2 | 456 |
| 16 | J.K. DobbinsDenver Broncos·#27 | 10 | 153 | 772 | 5.05 | 4 | 415 | 37 | 7 | 14 | 11 | 42 | 0 | 78.6% | 3.00 | 3.82 | 56 | 0 | 0 | 0 | 1 | 318 |
| 17 | Jahmyr GibbsDetroit Lions·#0 | 17 | 243 | 1,223 | 5.03 | 13 | 686 | 57 | 10 | 94 | 77 | 613 | 5 | 81.9% | 6.52 | 7.96 | 612 | 15 | 12 | 5 | 3 | 689 |
| 18 | AJ DillonPhiladelphia Eagles·#29 | 7 | 12 | 60 | 5.00 | 0 | 42 | 4 | 0 | 3 | 3 | 21 | 0 | 100.0% | 7.00 | 7.00 | 9 | 1 | 1 | 0 | 1 | 37 |
| 19 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 321 | 1,580 | 4.92 | 18 | 947 | 85 | 24 | 56 | 46 | 378 | 2 | 82.1% | 6.75 | 8.22 | 434 | 5 | 4 | 2 | 5 | 823 |
| 20 | D'Andre SwiftChicago Bears·#4 | 16 | 222 | 1,087 | 4.90 | 9 | 612 | 63 | 14 | 48 | 34 | 290 | 1 | 70.8% | 6.04 | 8.53 | 348 | 1 | 1 | 0 | 4 | 589 |
| 21 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 258 | 1,251 | 4.85 | 10 | 749 | 75 | 18 | 50 | 36 | 281 | 3 | 72.0% | 5.62 | 7.81 | 155 | 10 | 8 | 3 | 6 | 734 |
| 22 | Corey KinerArizona Cardinals·#37 | 4 | 12 | 58 | 4.83 | 0 | 26 | 4 | 0 | 3 | 2 | 15 | 0 | 66.7% | 5.00 | 7.50 | 6 | 1 | 1 | 0 | 0 | 27 |
| 23 | Malik DavisDallas Cowboys·#43 | 9 | 52 | 250 | 4.81 | 2 | 96 | 12 | 2 | 5 | 2 | 16 | 0 | 40.0% | 3.20 | 8.00 | 6 | 0 | 0 | 0 | 1 | 135 |
| 24 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 36 | 173 | 4.81 | 1 | 84 | 7 | 1 | 6 | 4 | 27 | 0 | 66.7% | 4.50 | 6.75 | 39 | 0 | 0 | 0 | 1 | 75 |
| 25 | Jordan MasonMinnesota Vikings·#27 | 16 | 159 | 758 | 4.77 | 6 | 443 | 45 | 7 | 16 | 14 | 51 | 0 | 87.5% | 3.19 | 3.64 | 102 | 1 | 1 | 0 | 3 | 387 |
| 26 | Raheem MostertLas Vegas Raiders·#31 | 12 | 21 | 100 | 4.76 | 0 | 84 | 5 | 0 | 12 | 12 | 70 | 0 | 100.0% | 5.83 | 5.83 | 86 | 1 | 1 | 0 | 1 | 119 |
| 27 | Javonte WilliamsDallas Cowboys·#33 | 16 | 248 | 1,175 | 4.74 | 11 | 742 | 66 | 20 | 51 | 35 | 137 | 2 | 68.6% | 2.69 | 3.91 | 206 | 12 | 8 | 2 | 4 | 713 |
| 28 | Ray DavisBuffalo Bills·#22 | 17 | 58 | 275 | 4.74 | 0 | 171 | 15 | 2 | 14 | 10 | 86 | 2 | 71.4% | 6.14 | 8.60 | 99 | 5 | 4 | 2 | 0 | 135 |
| 29 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 114 | 537 | 4.71 | 5 | 396 | 34 | 9 | 85 | 73 | 486 | 3 | 85.9% | 5.72 | 6.66 | 528 | 17 | 14 | 2 | 2 | 473 |
| 30 | Trevor EtienneCarolina Panthers·#23 | 11 | 20 | 94 | 4.70 | 0 | 55 | 7 | 1 | 3 | 3 | 13 | 0 | 100.0% | 4.33 | 4.33 | 11 | 0 | 0 | 0 | 0 | 42 |
| 31 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 219 | 1,015 | 4.63 | 5 | 546 | 48 | 8 | 36 | 31 | 282 | 0 | 86.1% | 7.83 | 9.10 | 339 | 3 | 2 | 0 | 5 | 451 |
| 32 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 13 | 60 | 4.62 | 1 | 32 | 3 | 1 | 17 | 16 | 99 | 0 | 94.1% | 5.82 | 6.19 | 105 | 1 | 1 | 0 | 0 | 77 |
| 33 | Rhamondre StevensonNew England Patriots·#38 | 14 | 131 | 605 | 4.62 | 7 | 402 | 29 | 12 | 38 | 32 | 347 | 2 | 84.2% | 9.13 | 10.84 | 263 | 6 | 5 | 1 | 4 | 481 |
| 34 | Kyle MonangaiChicago Bears·#25 | 17 | 170 | 783 | 4.61 | 5 | 407 | 43 | 12 | 30 | 18 | 164 | 0 | 60.0% | 5.47 | 9.11 | 162 | 3 | 2 | 0 | 0 | 450 |
| 35 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 175 | 805 | 4.60 | 8 | 498 | 41 | 13 | 13 | 9 | 68 | 0 | 69.2% | 5.23 | 7.56 | 77 | 1 | 1 | 0 | 3 | 371 |
| 36 | Rico DowdleCarolina Panthers·#5 | 17 | 235 | 1,071 | 4.56 | 6 | 646 | 54 | 9 | 49 | 39 | 297 | 1 | 79.6% | 6.06 | 7.62 | 350 | 5 | 3 | 0 | 6 | 539 |
| 37 | Samaje PerineCincinnati Bengals·#34 | 15 | 84 | 382 | 4.55 | 3 | 263 | 33 | 4 | 21 | 17 | 87 | 0 | 81.0% | 4.14 | 5.12 | 109 | 1 | 1 | 0 | 3 | 308 |
| 38 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 211 | 958 | 4.54 | 6 | 691 | 52 | 14 | 45 | 40 | 333 | 2 | 88.9% | 7.40 | 8.32 | 439 | 5 | 4 | 1 | 4 | 462 |
| 39 | David MontgomeryDetroit Lions·#5 | 17 | 159 | 718 | 4.52 | 8 | 434 | 42 | 17 | 29 | 24 | 192 | 0 | 82.8% | 6.62 | 8.00 | 199 | 2 | 1 | 0 | 5 | 388 |
| 40 | Jawhar JordanHouston Texans·#26 | 4 | 43 | 193 | 4.49 | 0 | 129 | 8 | 1 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 40 | 0 | 0 | 0 | 0 | 74 |
| 41 | Tony PollardTennessee Titans·#20 | 17 | 241 | 1,079 | 4.48 | 5 | 648 | 48 | 4 | 41 | 33 | 206 | 0 | 80.5% | 5.02 | 6.24 | 203 | 1 | 1 | 0 | 9 | 615 |
| 42 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 112 | 500 | 4.46 | 6 | 309 | 32 | 14 | 4 | 3 | 30 | 0 | 75.0% | 7.50 | 10.00 | 26 | 1 | 0 | 0 | 2 | 237 |
| 43 | Chase BrownCincinnati Bengals·#30 | 17 | 232 | 1,019 | 4.39 | 6 | 714 | 52 | 13 | 88 | 69 | 439 | 5 | 78.4% | 4.99 | 6.36 | 427 | 11 | 8 | 5 | 4 | 685 |
| 44 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 123 | 535 | 4.35 | 4 | 356 | 30 | 8 | 35 | 32 | 192 | 1 | 91.4% | 5.49 | 6.00 | 245 | 2 | 2 | 1 | 2 | 348 |
| 45 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 92 | 400 | 4.35 | 2 | 226 | 21 | 2 | 12 | 8 | 25 | 0 | 66.7% | 2.08 | 3.12 | 35 | 4 | 3 | 0 | 0 | 165 |
| 46 | Breece HallNew York Jets·#20 | 16 | 242 | 1,048 | 4.33 | 4 | 511 | 56 | 4 | 48 | 36 | 350 | 1 | 75.0% | 7.29 | 9.72 | 321 | 9 | 2 | 0 | 4 | 581 |
| 47 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 133 | 572 | 4.30 | 4 | 327 | 40 | 9 | 45 | 40 | 218 | 0 | 88.9% | 4.84 | 5.45 | 329 | 10 | 9 | 0 | 4 | 519 |
| 48 | Audric EstiméNew Orleans Saints·#30 | 5 | 46 | 198 | 4.30 | 1 | 182 | 12 | 3 | 13 | 12 | 103 | 0 | 92.3% | 7.92 | 8.58 | 108 | 0 | 0 | 0 | 1 | 163 |
| 49 | Travis EtienneJacksonville Jaguars·#1 | 17 | 259 | 1,109 | 4.28 | 7 | 739 | 51 | 12 | 52 | 36 | 292 | 6 | 69.2% | 5.62 | 8.11 | 339 | 10 | 8 | 5 | 1 | 639 |
| 50 | Antonio GibsonNew England Patriots·#4 | 5 | 25 | 106 | 4.24 | 1 | 62 | 6 | 2 | 3 | 2 | 6 | 0 | 66.7% | 2.00 | 3.00 | 16 | 0 | 0 | 0 | 1 | 46 |