| 1 | Jawhar JordanHouston Texans·#26 | 4 | 29 | 138 | 4.76 | 0 | 86 | 4 | 1 | 1 | 1 | 14 | 0 | 100.0% | 14.00 | 14.00 | 17 | 0 | 0 | 0 | 0 | 40 |
| 2 | Derrick HenryBaltimore Ravens·#22 | 17 | 174 | 1,045 | 6.01 | 9 | 586 | 31 | 12 | 12 | 10 | 131 | 0 | 83.3% | 10.92 | 13.10 | 124 | 0 | 0 | 0 | 3 | 303 |
| 3 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 69 | 280 | 4.06 | 2 | 205 | 9 | 3 | 6 | 6 | 62 | 0 | 100.0% | 10.33 | 10.33 | 68 | 0 | 0 | 0 | 0 | 133 |
| 4 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 120 | 545 | 4.54 | 3 | 363 | 13 | 6 | 5 | 4 | 50 | 0 | 80.0% | 10.00 | 12.50 | 39 | 1 | 1 | 0 | 2 | 204 |
| 5 | Breece HallNew York Jets·#20 | 16 | 128 | 702 | 5.48 | 3 | 321 | 21 | 2 | 26 | 23 | 254 | 0 | 88.5% | 9.77 | 11.04 | 230 | 2 | 0 | 0 | 2 | 285 |
| 6 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 125 | 630 | 5.04 | 2 | 305 | 23 | 4 | 16 | 13 | 150 | 0 | 81.3% | 9.38 | 11.54 | 162 | 1 | 0 | 0 | 1 | 243 |
| 7 | Kaleb JohnsonPittsburgh Steelers·#20 | 10 | 18 | 47 | 2.61 | 0 | 34 | 1 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 14 | 0 | 0 | 0 | 0 | 27 |
| 8 | Hassan HaskinsLos Angeles Chargers·#28 | 9 | 11 | 32 | 2.91 | 0 | 17 | 1 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 7 | 0 | 0 | 0 | 0 | 32 |
| 9 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 173 | 1,020 | 5.90 | 5 | 768 | 25 | 6 | 42 | 36 | 372 | 1 | 85.7% | 8.86 | 10.33 | 437 | 3 | 3 | 1 | 3 | 349 |
| 10 | Cam SkatteboNew York Giants·#44 | 8 | 55 | 261 | 4.75 | 4 | 197 | 10 | 5 | 14 | 12 | 120 | 1 | 85.7% | 8.57 | 10.00 | 117 | 1 | 1 | 1 | 1 | 112 |
| 11 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 113 | 565 | 5.00 | 2 | 400 | 14 | 7 | 21 | 19 | 180 | 1 | 90.5% | 8.57 | 9.47 | 244 | 3 | 2 | 1 | 1 | 229 |
| 12 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 20 | 106 | 5.30 | 0 | 48 | 3 | 0 | 2 | 1 | 17 | 0 | 50.0% | 8.50 | 17.00 | 22 | 0 | 0 | 0 | 0 | 38 |
| 13 | Bhayshul TutenJacksonville Jaguars·#33 | 15 | 47 | 193 | 4.11 | 3 | 130 | 7 | 4 | 7 | 6 | 56 | 1 | 85.7% | 8.00 | 9.33 | 50 | 1 | 1 | 1 | 1 | 90 |
| 14 | Kendre MillerNew Orleans Saints·#5 | 7 | 32 | 125 | 3.91 | 1 | 91 | 2 | 0 | 2 | 2 | 16 | 0 | 100.0% | 8.00 | 8.00 | 17 | 0 | 0 | 0 | 1 | 56 |
| 15 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 101 | 363 | 3.59 | 0 | 202 | 6 | 0 | 17 | 15 | 135 | 1 | 88.2% | 7.94 | 9.00 | 194 | 0 | 0 | 0 | 0 | 196 |
| 16 | David MontgomeryDetroit Lions·#5 | 17 | 82 | 358 | 4.37 | 3 | 195 | 13 | 7 | 18 | 15 | 139 | 0 | 83.3% | 7.72 | 9.27 | 144 | 1 | 0 | 0 | 2 | 170 |
| 17 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 185 | 711 | 3.84 | 5 | 436 | 22 | 11 | 46 | 39 | 353 | 1 | 84.8% | 7.67 | 9.05 | 303 | 4 | 3 | 1 | 4 | 398 |
| 18 | Justice HillBaltimore Ravens·#43 | 10 | 7 | 66 | 9.43 | 2 | 75 | 2 | 1 | 5 | 4 | 38 | 0 | 80.0% | 7.60 | 9.50 | 37 | 0 | 0 | 0 | 1 | 38 |
| 19 | Audric EstiméNew Orleans Saints·#30 | 5 | 24 | 128 | 5.33 | 1 | 127 | 2 | 1 | 6 | 6 | 45 | 0 | 100.0% | 7.50 | 7.50 | 52 | 0 | 0 | 0 | 1 | 62 |
| 20 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 74 | 285 | 3.85 | 3 | 191 | 10 | 3 | 9 | 9 | 65 | 0 | 100.0% | 7.22 | 7.22 | 90 | 1 | 1 | 0 | 0 | 130 |
| 21 | Kyle MonangaiChicago Bears·#25 | 17 | 88 | 426 | 4.84 | 3 | 214 | 12 | 3 | 10 | 7 | 72 | 0 | 70.0% | 7.20 | 10.29 | 80 | 0 | 0 | 0 | 0 | 198 |
| 22 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 179 | 877 | 4.90 | 7 | 542 | 22 | 11 | 30 | 24 | 214 | 2 | 80.0% | 7.13 | 8.92 | 243 | 3 | 3 | 2 | 1 | 388 |
| 23 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 95 | 372 | 3.92 | 0 | 259 | 11 | 1 | 19 | 14 | 130 | 1 | 73.7% | 6.84 | 9.29 | 131 | 2 | 1 | 1 | 1 | 225 |
| 24 | Michael CarterArizona Cardinals·#22 | 12 | 57 | 192 | 3.37 | 0 | 137 | 3 | 0 | 24 | 17 | 161 | 0 | 70.8% | 6.71 | 9.47 | 158 | 2 | 2 | 0 | 0 | 167 |
| 25 | Kareem HuntKansas City Chiefs·#29 | 17 | 81 | 352 | 4.35 | 2 | 220 | 8 | 6 | 9 | 7 | 60 | 0 | 77.8% | 6.67 | 8.57 | 77 | 2 | 1 | 0 | 0 | 181 |
| 26 | Devin NealNew Orleans Saints·#24 | 9 | 32 | 117 | 3.66 | 2 | 54 | 4 | 2 | 5 | 4 | 33 | 0 | 80.0% | 6.60 | 8.25 | 26 | 0 | 0 | 0 | 0 | 91 |
| 27 | RJ HarveyDenver Broncos·#12 | 17 | 80 | 321 | 4.01 | 3 | 241 | 8 | 5 | 21 | 16 | 138 | 1 | 76.2% | 6.57 | 8.62 | 114 | 2 | 1 | 0 | 0 | 198 |
| 28 | Rhamondre StevensonNew England Patriots·#38 | 14 | 75 | 303 | 4.04 | 4 | 181 | 8 | 6 | 16 | 13 | 105 | 0 | 81.3% | 6.56 | 8.08 | 101 | 1 | 1 | 0 | 2 | 197 |
| 29 | Chris BrooksGreen Bay Packers·#30 | 14 | 14 | 67 | 4.79 | 0 | 44 | 2 | 0 | 6 | 5 | 39 | 0 | 83.3% | 6.50 | 7.80 | 47 | 0 | 0 | 0 | 0 | 50 |
| 30 | Josh JacobsGreen Bay Packers·#8 | 15 | 125 | 493 | 3.94 | 4 | 331 | 14 | 8 | 23 | 20 | 149 | 0 | 87.0% | 6.48 | 7.45 | 181 | 2 | 2 | 0 | 3 | 241 |
| 31 | Aaron JonesMinnesota Vikings·#33 | 12 | 75 | 310 | 4.13 | 1 | 200 | 7 | 1 | 15 | 10 | 96 | 1 | 66.7% | 6.40 | 9.60 | 92 | 0 | 0 | 0 | 1 | 161 |
| 32 | James CookBuffalo Bills·#4 | 17 | 206 | 1,050 | 5.10 | 4 | 547 | 30 | 4 | 19 | 17 | 121 | 1 | 89.5% | 6.37 | 7.12 | 91 | 1 | 1 | 0 | 4 | 324 |
| 33 | Kimani VidalLos Angeles Chargers·#30 | 12 | 96 | 358 | 3.73 | 2 | 177 | 12 | 5 | 3 | 2 | 19 | 0 | 66.7% | 6.33 | 9.50 | 19 | 1 | 1 | 0 | 0 | 185 |
| 34 | De'Von AchaneMiami Dolphins·#28 | 16 | 138 | 729 | 5.28 | 5 | 441 | 21 | 2 | 32 | 26 | 201 | 0 | 81.3% | 6.28 | 7.73 | 260 | 2 | 1 | 0 | 0 | 282 |
| 35 | Brashard SmithKansas City Chiefs·#24 | 17 | 27 | 97 | 3.59 | 0 | 61 | 1 | 0 | 16 | 13 | 100 | 0 | 81.3% | 6.25 | 7.69 | 140 | 3 | 2 | 0 | 0 | 75 |
| 36 | Rico DowdleCarolina Panthers·#5 | 17 | 143 | 685 | 4.79 | 2 | 369 | 22 | 3 | 19 | 15 | 117 | 1 | 79.0% | 6.16 | 7.80 | 117 | 2 | 1 | 0 | 3 | 254 |
| 37 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 139 | 691 | 4.97 | 6 | 403 | 21 | 9 | 22 | 18 | 133 | 2 | 81.8% | 6.05 | 7.39 | 93 | 2 | 2 | 2 | 4 | 321 |
| 38 | Emari DemercadoArizona Cardinals·#31 | 11 | 23 | 82 | 3.57 | 0 | 47 | 3 | 0 | 3 | 3 | 18 | 0 | 100.0% | 6.00 | 6.00 | 30 | 0 | 0 | 0 | 0 | 50 |
| 39 | Chris Rodriguez Jr.Washington Commanders·#36 | 11 | 63 | 262 | 4.16 | 2 | 160 | 8 | 6 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 3 | 0 | 0 | 0 | 1 | 114 |
| 40 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 61 | 311 | 5.10 | 3 | 183 | 14 | 4 | 18 | 17 | 104 | 0 | 94.4% | 5.78 | 6.12 | 120 | 3 | 3 | 0 | 0 | 167 |
| 41 | Quinshon JudkinsCleveland Browns·#10 | 14 | 130 | 525 | 4.04 | 4 | 340 | 15 | 7 | 23 | 16 | 131 | 0 | 69.6% | 5.70 | 8.19 | 139 | 1 | 1 | 0 | 1 | 226 |
| 42 | Jahmyr GibbsDetroit Lions·#0 | 17 | 131 | 658 | 5.02 | 5 | 294 | 15 | 3 | 33 | 27 | 176 | 1 | 81.8% | 5.33 | 6.52 | 158 | 6 | 5 | 1 | 2 | 301 |
| 43 | Chuba HubbardCarolina Panthers·#30 | 15 | 66 | 265 | 4.02 | 1 | 165 | 3 | 1 | 12 | 7 | 63 | 1 | 58.3% | 5.25 | 9.00 | 76 | 1 | 0 | 0 | 1 | 150 |
| 44 | Travis EtienneJacksonville Jaguars·#1 | 17 | 156 | 733 | 4.70 | 5 | 465 | 19 | 6 | 21 | 16 | 109 | 2 | 76.2% | 5.19 | 6.81 | 143 | 3 | 3 | 2 | 1 | 333 |
| 45 | Isaiah DavisNew York Jets·#32 | 15 | 16 | 104 | 6.50 | 0 | 92 | 3 | 0 | 13 | 8 | 66 | 0 | 61.5% | 5.08 | 8.25 | 49 | 1 | 1 | 0 | 0 | 69 |
| 46 | Chase BrownCincinnati Bengals·#30 | 17 | 148 | 704 | 4.76 | 3 | 493 | 20 | 7 | 42 | 36 | 209 | 2 | 85.7% | 4.98 | 5.81 | 201 | 5 | 4 | 2 | 3 | 355 |
| 47 | TreVeyon HendersonNew England Patriots·#32 | 17 | 107 | 564 | 5.27 | 7 | 230 | 14 | 2 | 19 | 15 | 92 | 0 | 79.0% | 4.84 | 6.13 | 100 | 0 | 0 | 0 | 1 | 210 |
| 48 | Bam KnightArizona Cardinals·#20 | 10 | 50 | 159 | 3.18 | 2 | 119 | 5 | 4 | 13 | 8 | 62 | 0 | 61.5% | 4.77 | 7.75 | 70 | 2 | 1 | 0 | 2 | 136 |
| 49 | Javonte WilliamsDallas Cowboys·#33 | 16 | 159 | 810 | 5.09 | 8 | 507 | 26 | 15 | 18 | 16 | 84 | 0 | 88.9% | 4.67 | 5.25 | 127 | 2 | 2 | 0 | 1 | 333 |
| 50 | Will ShipleyPhiladelphia Eagles·#28 | 12 | 4 | 17 | 4.25 | 0 | 5 | 1 | 0 | 3 | 3 | 14 | 0 | 100.0% | 4.67 | 4.67 | 23 | 0 | 0 | 0 | 0 | 25 |