| 1 | Tank BigsbyPhiladelphia Eagles·#37 | 10 | 19 | 115 | 6.05 | 0 | 74 | 5 | 0 | 3 | 2 | 33 | 0 | 66.7% | 11.00 | 16.50 | 33 | 1 | 1 | 0 | 0 | 51 |
| 2 | Kimani VidalLos Angeles Chargers·#30 | 13 | 72 | 267 | 3.71 | 1 | 187 | 21 | 4 | 11 | 9 | 110 | 0 | 81.8% | 10.00 | 12.22 | 136 | 1 | 0 | 0 | 0 | 225 |
| 3 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 102 | 392 | 3.84 | 2 | 220 | 18 | 5 | 16 | 14 | 157 | 0 | 87.5% | 9.81 | 11.21 | 194 | 2 | 1 | 0 | 2 | 211 |
| 4 | Dare OgunbowaleHouston Texans·#33 | 15 | 4 | 13 | 3.25 | 0 | 18 | 0 | 1 | 4 | 4 | 37 | 0 | 100.0% | 9.25 | 9.25 | 36 | 0 | 0 | 0 | 1 | 76 |
| 5 | Ty JohnsonBuffalo Bills·#26 | 17 | 24 | 119 | 4.96 | 3 | 63 | 8 | 2 | 18 | 13 | 165 | 1 | 72.2% | 9.17 | 12.69 | 175 | 2 | 1 | 0 | 0 | 145 |
| 6 | Hassan HaskinsLos Angeles Chargers·#28 | 6 | 7 | 16 | 2.29 | 0 | 10 | 2 | 0 | 1 | 1 | 9 | 0 | 100.0% | 9.00 | 9.00 | 7 | 0 | 0 | 0 | 2 | 29 |
| 7 | Rhamondre StevensonNew England Patriots·#38 | 14 | 79 | 448 | 5.67 | 2 | 236 | 21 | 4 | 19 | 18 | 168 | 1 | 94.7% | 8.84 | 9.33 | 125 | 3 | 3 | 0 | 3 | 262 |
| 8 | Jeremy McNicholsWashington Commanders·#26 | 16 | 19 | 131 | 6.89 | 1 | 144 | 6 | 0 | 14 | 13 | 118 | 0 | 92.9% | 8.43 | 9.08 | 139 | 1 | 1 | 0 | 0 | 133 |
| 9 | Rasheen AliBaltimore Ravens·#26 | 8 | 2 | 5 | 2.50 | 0 | 27 | 0 | 0 | 7 | 5 | 59 | 1 | 71.4% | 8.43 | 11.80 | 69 | 0 | 0 | 0 | 2 | 47 |
| 10 | Kareem HuntKansas City Chiefs·#29 | 17 | 72 | 327 | 4.54 | 1 | 194 | 29 | 3 | 12 | 12 | 94 | 0 | 100.0% | 7.83 | 7.83 | 100 | 0 | 0 | 0 | 0 | 228 |
| 11 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 165 | 669 | 4.05 | 7 | 367 | 41 | 14 | 32 | 25 | 242 | 1 | 78.1% | 7.56 | 9.68 | 258 | 2 | 2 | 1 | 2 | 470 |
| 12 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 8 | 48 | 6.00 | 0 | 23 | 2 | 0 | 6 | 6 | 45 | 0 | 100.0% | 7.50 | 7.50 | 44 | 1 | 1 | 0 | 0 | 28 |
| 13 | Tyjae SpearsTennessee Titans·#2 | 13 | 45 | 211 | 4.69 | 0 | 162 | 12 | 0 | 22 | 21 | 157 | 0 | 95.5% | 7.14 | 7.48 | 199 | 2 | 2 | 0 | 1 | 171 |
| 14 | Quinshon JudkinsCleveland Browns·#10 | 14 | 127 | 415 | 3.27 | 5 | 272 | 27 | 9 | 18 | 14 | 124 | 0 | 77.8% | 6.89 | 8.86 | 151 | 1 | 1 | 0 | 1 | 237 |
| 15 | Josh JacobsGreen Bay Packers·#8 | 15 | 111 | 436 | 3.93 | 2 | 308 | 26 | 6 | 25 | 23 | 169 | 1 | 92.0% | 6.76 | 7.35 | 188 | 3 | 3 | 1 | 3 | 269 |
| 16 | TreVeyon HendersonNew England Patriots·#32 | 17 | 95 | 421 | 4.43 | 5 | 178 | 25 | 6 | 23 | 21 | 155 | 0 | 91.3% | 6.74 | 7.38 | 160 | 1 | 1 | 0 | 1 | 244 |
| 17 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 87 | 284 | 3.26 | 0 | 177 | 13 | 0 | 18 | 16 | 119 | 1 | 88.9% | 6.61 | 7.44 | 173 | 2 | 2 | 0 | 0 | 204 |
| 18 | Jerome FordCleveland Browns·#34 | 13 | 11 | 31 | 2.82 | 0 | 24 | 2 | 3 | 9 | 8 | 59 | 0 | 88.9% | 6.56 | 7.38 | 85 | 2 | 2 | 0 | 0 | 92 |
| 19 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 84 | 292 | 3.48 | 1 | 253 | 15 | 1 | 20 | 16 | 129 | 0 | 80.0% | 6.45 | 8.06 | 162 | 2 | 1 | 0 | 0 | 255 |
| 20 | Chris BrooksGreen Bay Packers·#30 | 17 | 11 | 45 | 4.09 | 0 | 36 | 2 | 0 | 12 | 11 | 77 | 0 | 91.7% | 6.42 | 7.00 | 87 | 2 | 1 | 0 | 0 | 94 |
| 21 | Breece HallNew York Jets·#20 | 16 | 129 | 515 | 3.99 | 1 | 260 | 26 | 2 | 24 | 19 | 152 | 0 | 79.2% | 6.33 | 8.00 | 148 | 4 | 1 | 0 | 2 | 262 |
| 22 | Jahmyr GibbsDetroit Lions·#0 | 17 | 127 | 626 | 4.93 | 6 | 365 | 31 | 7 | 46 | 39 | 291 | 3 | 84.8% | 6.33 | 7.46 | 290 | 9 | 6 | 3 | 2 | 350 |
| 23 | David MontgomeryDetroit Lions·#5 | 17 | 85 | 303 | 3.56 | 5 | 197 | 23 | 14 | 13 | 12 | 82 | 0 | 92.3% | 6.31 | 6.83 | 90 | 0 | 0 | 0 | 3 | 206 |
| 24 | Woody MarksHouston Texans·#27 | 16 | 99 | 391 | 3.95 | 1 | 271 | 27 | 6 | 23 | 16 | 144 | 1 | 69.6% | 6.26 | 9.00 | 159 | 3 | 2 | 1 | 0 | 277 |
| 25 | Cam SkatteboNew York Giants·#44 | 8 | 46 | 190 | 4.13 | 2 | 135 | 12 | 3 | 16 | 11 | 100 | 2 | 68.8% | 6.25 | 9.09 | 100 | 2 | 2 | 2 | 0 | 119 |
| 26 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 160 | 970 | 6.06 | 5 | 625 | 39 | 5 | 53 | 38 | 328 | 3 | 71.7% | 6.19 | 8.63 | 367 | 9 | 6 | 2 | 3 | 428 |
| 27 | Will ShipleyPhiladelphia Eagles·#28 | 15 | 8 | 37 | 4.62 | 0 | 14 | 3 | 0 | 6 | 5 | 36 | 0 | 83.3% | 6.00 | 7.20 | 20 | 1 | 0 | 0 | 0 | 61 |
| 28 | Ray DavisBuffalo Bills·#22 | 14 | 17 | 95 | 5.59 | 0 | 44 | 5 | 0 | 7 | 5 | 42 | 1 | 71.4% | 6.00 | 8.40 | 51 | 2 | 2 | 1 | 0 | 50 |
| 29 | Evan HullNew Orleans Saints·#34 | 6 | 11 | 24 | 2.18 | 0 | 9 | 1 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 1 | 35 |
| 30 | Bhayshul TutenJacksonville Jaguars·#33 | 15 | 36 | 150 | 4.17 | 2 | 102 | 11 | 3 | 11 | 8 | 65 | 2 | 72.7% | 5.91 | 8.12 | 68 | 2 | 2 | 2 | 1 | 104 |
| 31 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 56 | 263 | 4.70 | 3 | 182 | 17 | 4 | 47 | 42 | 273 | 2 | 89.4% | 5.81 | 6.50 | 304 | 10 | 9 | 1 | 0 | 240 |
| 32 | Chuba HubbardCarolina Panthers·#30 | 15 | 69 | 262 | 3.80 | 0 | 158 | 12 | 0 | 18 | 14 | 104 | 1 | 77.8% | 5.78 | 7.43 | 156 | 2 | 1 | 0 | 1 | 194 |
| 33 | De'Von AchaneMiami Dolphins·#28 | 16 | 123 | 834 | 6.78 | 4 | 436 | 27 | 1 | 49 | 38 | 280 | 3 | 77.5% | 5.71 | 7.37 | 318 | 8 | 4 | 2 | 2 | 331 |
| 34 | Keaton MitchellBaltimore Ravens·#34 | 13 | 28 | 128 | 4.57 | 0 | 73 | 7 | 0 | 7 | 6 | 40 | 0 | 85.7% | 5.71 | 6.67 | 49 | 0 | 0 | 0 | 1 | 64 |
| 35 | Jaylen WrightMiami Dolphins·#5 | 9 | 37 | 162 | 4.38 | 1 | 115 | 7 | 3 | 3 | 2 | 17 | 0 | 66.7% | 5.67 | 8.50 | 25 | 0 | 0 | 0 | 1 | 57 |
| 36 | Audric EstiméNew Orleans Saints·#30 | 5 | 14 | 33 | 2.36 | 0 | 34 | 2 | 2 | 7 | 6 | 39 | 0 | 85.7% | 5.57 | 6.50 | 32 | 0 | 0 | 0 | 0 | 65 |
| 37 | Michael CarterArizona Cardinals·#22 | 13 | 44 | 171 | 3.89 | 1 | 117 | 8 | 3 | 16 | 12 | 89 | 0 | 75.0% | 5.56 | 7.42 | 77 | 3 | 3 | 0 | 0 | 150 |
| 38 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 84 | 353 | 4.20 | 6 | 234 | 25 | 9 | 8 | 6 | 42 | 0 | 75.0% | 5.25 | 7.00 | 35 | 0 | 0 | 0 | 2 | 214 |
| 39 | Derrick HenryBaltimore Ravens·#22 | 17 | 157 | 801 | 5.10 | 9 | 466 | 42 | 14 | 9 | 7 | 47 | 0 | 77.8% | 5.22 | 6.71 | 41 | 1 | 1 | 0 | 1 | 266 |
| 40 | Tony PollardTennessee Titans·#20 | 17 | 127 | 602 | 4.74 | 1 | 358 | 20 | 0 | 16 | 11 | 83 | 0 | 68.8% | 5.19 | 7.55 | 102 | 1 | 1 | 0 | 3 | 303 |
| 41 | Justice HillBaltimore Ravens·#43 | 10 | 10 | 13 | 1.30 | 0 | 22 | 2 | 0 | 13 | 10 | 67 | 1 | 76.9% | 5.15 | 6.70 | 74 | 1 | 1 | 1 | 1 | 92 |
| 42 | Brashard SmithKansas City Chiefs·#24 | 16 | 17 | 63 | 3.71 | 0 | 43 | 3 | 0 | 18 | 12 | 91 | 1 | 66.7% | 5.06 | 7.58 | 114 | 5 | 4 | 1 | 1 | 81 |
| 43 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 108 | 454 | 4.20 | 3 | 266 | 26 | 9 | 24 | 23 | 121 | 0 | 95.8% | 5.04 | 5.26 | 180 | 1 | 1 | 0 | 0 | 242 |
| 44 | Antonio GibsonNew England Patriots·#4 | 4 | 19 | 76 | 4.00 | 1 | 49 | 5 | 1 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 11 | 0 | 0 | 0 | 0 | 32 |
| 45 | Emanuel WilsonGreen Bay Packers·#23 | 16 | 50 | 158 | 3.16 | 2 | 128 | 11 | 1 | 7 | 6 | 35 | 0 | 85.7% | 5.00 | 5.83 | 55 | 0 | 0 | 0 | 0 | 124 |
| 46 | Chase BrownCincinnati Bengals·#30 | 17 | 126 | 607 | 4.82 | 2 | 386 | 27 | 5 | 38 | 29 | 189 | 3 | 76.3% | 4.97 | 6.52 | 188 | 4 | 4 | 3 | 2 | 349 |
| 47 | Alvin KamaraNew Orleans Saints·#41 | 11 | 75 | 279 | 3.72 | 1 | 184 | 10 | 1 | 27 | 22 | 134 | 0 | 81.5% | 4.96 | 6.09 | 146 | 3 | 2 | 0 | 4 | 239 |
| 48 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 81 | 368 | 4.54 | 2 | 207 | 22 | 6 | 21 | 20 | 104 | 0 | 95.2% | 4.95 | 5.20 | 161 | 6 | 6 | 0 | 2 | 257 |
| 49 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 153 | 641 | 4.19 | 6 | 381 | 39 | 9 | 64 | 48 | 316 | 5 | 75.0% | 4.94 | 6.58 | 231 | 13 | 11 | 5 | 3 | 459 |
| 50 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 64 | 239 | 3.73 | 1 | 205 | 16 | 1 | 18 | 16 | 88 | 1 | 88.9% | 4.89 | 5.50 | 130 | 1 | 1 | 1 | 1 | 182 |