| 1 | James ConnerArizona Cardinals·#6 | 1 | 11 | 34 | 3.09 | 1 | 29 | 3 | 2 | 1 | 1 | 18 | 0 | 100.0% | 18.00 | 18.00 | 18 | 0 | 0 | 0 | 0 | 25 |
| 2 | Tank BigsbyPhiladelphia Eagles·#37 | 5 | 44 | 254 | 5.77 | 1 | 192 | 14 | 6 | 2 | 1 | 31 | 0 | 50.0% | 15.50 | 31.00 | 30 | 0 | 0 | 0 | 0 | 83 |
| 3 | Bucky IrvingTampa Bay Buccaneers·#7 | 6 | 114 | 390 | 3.42 | 1 | 237 | 18 | 0 | 19 | 15 | 205 | 2 | 79.0% | 10.79 | 13.67 | 252 | 3 | 2 | 0 | 1 | 234 |
| 4 | Austin EkelerWashington Commanders·#30 | 1 | 6 | 26 | 4.33 | 0 | 24 | 1 | 0 | 3 | 3 | 31 | 0 | 100.0% | 10.33 | 10.33 | 38 | 0 | 0 | 0 | 0 | 32 |
| 5 | Derrick HenryBaltimore Ravens·#22 | 9 | 157 | 645 | 4.11 | 9 | 344 | 37 | 18 | 9 | 6 | 91 | 0 | 66.7% | 10.11 | 15.17 | 84 | 2 | 2 | 0 | 3 | 277 |
| 6 | Trayveon WilliamsCleveland Browns·#38 | 2 | 5 | 27 | 5.40 | 0 | 24 | 2 | 0 | 4 | 4 | 38 | 0 | 100.0% | 9.50 | 9.50 | 56 | 1 | 1 | 0 | 0 | 30 |
| 7 | Bijan RobinsonAtlanta Falcons·#7 | 8 | 137 | 712 | 5.20 | 5 | 577 | 26 | 6 | 41 | 33 | 388 | 2 | 80.5% | 9.46 | 11.76 | 392 | 5 | 3 | 1 | 2 | 356 |
| 8 | Rhamondre StevensonNew England Patriots·#38 | 7 | 59 | 326 | 5.53 | 2 | 224 | 13 | 4 | 17 | 15 | 157 | 1 | 88.2% | 9.24 | 10.47 | 133 | 4 | 4 | 1 | 2 | 228 |
| 9 | Jaylen WrightMiami Dolphins·#5 | 5 | 23 | 128 | 5.57 | 1 | 124 | 7 | 1 | 2 | 1 | 18 | 0 | 50.0% | 9.00 | 18.00 | 23 | 0 | 0 | 0 | 0 | 37 |
| 10 | Zavier ScottMinnesota Vikings·#36 | 4 | 18 | 58 | 3.22 | 0 | 44 | 3 | 1 | 4 | 4 | 35 | 0 | 100.0% | 8.75 | 8.75 | 47 | 1 | 1 | 0 | 0 | 37 |
| 11 | James CookBuffalo Bills·#4 | 9 | 152 | 649 | 4.27 | 3 | 455 | 28 | 9 | 23 | 18 | 197 | 1 | 78.3% | 8.57 | 10.94 | 179 | 1 | 1 | 0 | 4 | 327 |
| 12 | Kimani VidalLos Angeles Chargers·#30 | 6 | 100 | 420 | 4.20 | 3 | 201 | 25 | 6 | 13 | 9 | 110 | 0 | 69.2% | 8.46 | 12.22 | 118 | 3 | 1 | 0 | 0 | 269 |
| 13 | Audric EstiméNew Orleans Saints·#30 | 2 | 8 | 30 | 3.75 | 0 | 36 | 3 | 0 | 7 | 6 | 56 | 0 | 85.7% | 8.00 | 9.33 | 70 | 0 | 0 | 0 | 0 | 62 |
| 14 | Jonathan TaylorIndianapolis Colts·#28 | 9 | 182 | 1,018 | 5.59 | 11 | 578 | 53 | 16 | 33 | 26 | 257 | 2 | 78.8% | 7.79 | 9.88 | 267 | 5 | 4 | 2 | 1 | 462 |
| 15 | Nick ChubbHouston Texans·#21 | 7 | 70 | 276 | 3.94 | 1 | 195 | 10 | 3 | 9 | 9 | 70 | 0 | 100.0% | 7.78 | 7.78 | 60 | 0 | 0 | 0 | 0 | 149 |
| 16 | Breece HallNew York Jets·#20 | 9 | 144 | 651 | 4.52 | 2 | 242 | 35 | 3 | 22 | 15 | 171 | 1 | 68.2% | 7.77 | 11.40 | 143 | 5 | 2 | 0 | 2 | 328 |
| 17 | George HolaniSeattle Seahawks·#36 | 2 | 17 | 58 | 3.41 | 1 | 58 | 5 | 0 | 2 | 2 | 15 | 0 | 100.0% | 7.50 | 7.50 | 16 | 0 | 0 | 0 | 1 | 29 |
| 18 | Woody MarksHouston Texans·#27 | 8 | 88 | 387 | 4.40 | 2 | 270 | 25 | 5 | 21 | 15 | 157 | 1 | 71.4% | 7.48 | 10.47 | 166 | 4 | 2 | 1 | 0 | 247 |
| 19 | Ty JohnsonBuffalo Bills·#26 | 9 | 31 | 140 | 4.52 | 2 | 82 | 8 | 5 | 17 | 12 | 127 | 2 | 70.6% | 7.47 | 10.58 | 152 | 3 | 2 | 1 | 0 | 152 |
| 20 | Kenneth Walker IIISeattle Seahawks·#9 | 8 | 100 | 450 | 4.50 | 3 | 257 | 18 | 4 | 14 | 13 | 103 | 0 | 92.9% | 7.36 | 7.92 | 132 | 1 | 1 | 0 | 4 | 202 |
| 21 | Kareem HuntKansas City Chiefs·#29 | 9 | 95 | 330 | 3.47 | 3 | 214 | 37 | 5 | 9 | 8 | 63 | 1 | 88.9% | 7.00 | 7.88 | 64 | 3 | 2 | 1 | 1 | 250 |
| 22 | Kendre MillerNew Orleans Saints·#5 | 4 | 28 | 94 | 3.36 | 0 | 78 | 4 | 0 | 3 | 3 | 21 | 0 | 100.0% | 7.00 | 7.00 | 17 | 0 | 0 | 0 | 1 | 62 |
| 23 | Cam SkatteboNew York Giants·#44 | 3 | 55 | 239 | 4.35 | 4 | 169 | 17 | 8 | 12 | 10 | 84 | 0 | 83.3% | 7.00 | 8.40 | 89 | 0 | 0 | 0 | 0 | 125 |
| 24 | Christian McCaffreySan Francisco 49ers·#23 | 8 | 146 | 575 | 3.94 | 5 | 349 | 31 | 9 | 63 | 49 | 440 | 1 | 77.8% | 6.98 | 8.98 | 330 | 7 | 5 | 1 | 4 | 405 |
| 25 | Quinshon JudkinsCleveland Browns·#10 | 7 | 129 | 488 | 3.78 | 4 | 370 | 29 | 9 | 18 | 11 | 124 | 0 | 61.1% | 6.89 | 11.27 | 136 | 1 | 1 | 0 | 0 | 225 |
| 26 | Chris BrooksGreen Bay Packers·#30 | 8 | 10 | 23 | 2.30 | 0 | 34 | 2 | 0 | 11 | 9 | 75 | 0 | 81.8% | 6.82 | 8.33 | 90 | 2 | 1 | 0 | 0 | 83 |
| 27 | Dylan SampsonCleveland Browns·#22 | 8 | 35 | 108 | 3.09 | 0 | 167 | 5 | 0 | 21 | 18 | 143 | 0 | 85.7% | 6.81 | 7.94 | 184 | 3 | 2 | 0 | 1 | 107 |
| 28 | Tyler AllgeierAtlanta Falcons·#25 | 8 | 71 | 194 | 2.73 | 4 | 174 | 13 | 5 | 9 | 8 | 61 | 0 | 88.9% | 6.78 | 7.62 | 76 | 0 | 0 | 0 | 0 | 139 |
| 29 | Jaylen WarrenPittsburgh Steelers·#30 | 8 | 100 | 389 | 3.89 | 3 | 269 | 23 | 9 | 25 | 22 | 168 | 0 | 88.0% | 6.72 | 7.64 | 229 | 3 | 2 | 0 | 2 | 230 |
| 30 | Justice HillBaltimore Ravens·#43 | 6 | 11 | 28 | 2.55 | 0 | 30 | 1 | 0 | 15 | 12 | 100 | 0 | 80.0% | 6.67 | 8.33 | 99 | 0 | 0 | 0 | 1 | 114 |
| 31 | Kyle MonangaiChicago Bears·#25 | 8 | 65 | 272 | 4.18 | 3 | 143 | 17 | 5 | 13 | 8 | 86 | 0 | 61.5% | 6.62 | 10.75 | 64 | 1 | 1 | 0 | 0 | 189 |
| 32 | Jahmyr GibbsDetroit Lions·#0 | 8 | 107 | 678 | 6.34 | 9 | 302 | 31 | 4 | 47 | 42 | 307 | 2 | 89.4% | 6.53 | 7.31 | 304 | 6 | 5 | 2 | 0 | 325 |
| 33 | Raheem MostertLas Vegas Raiders·#31 | 6 | 12 | 66 | 5.50 | 0 | 74 | 4 | 0 | 8 | 8 | 52 | 0 | 100.0% | 6.50 | 6.50 | 65 | 0 | 0 | 0 | 1 | 61 |
| 34 | De'Von AchaneMiami Dolphins·#28 | 9 | 159 | 916 | 5.76 | 7 | 542 | 42 | 4 | 45 | 36 | 289 | 1 | 80.0% | 6.42 | 8.03 | 327 | 7 | 4 | 0 | 2 | 392 |
| 35 | Tyrone Tracy Jr.New York Giants·#29 | 7 | 83 | 380 | 4.58 | 1 | 309 | 22 | 0 | 26 | 22 | 167 | 2 | 84.6% | 6.42 | 7.59 | 181 | 3 | 3 | 2 | 2 | 219 |
| 36 | Kenneth GainwellPittsburgh Steelers·#14 | 9 | 70 | 305 | 4.36 | 3 | 210 | 21 | 6 | 51 | 45 | 320 | 2 | 88.2% | 6.27 | 7.11 | 370 | 9 | 8 | 2 | 1 | 252 |
| 37 | Tyjae SpearsTennessee Titans·#2 | 7 | 40 | 108 | 2.70 | 1 | 138 | 5 | 1 | 30 | 27 | 183 | 0 | 90.0% | 6.10 | 6.78 | 237 | 4 | 4 | 0 | 1 | 193 |
| 38 | Brashard SmithKansas City Chiefs·#24 | 9 | 26 | 71 | 2.73 | 0 | 75 | 2 | 1 | 22 | 17 | 133 | 1 | 77.3% | 6.05 | 7.82 | 161 | 4 | 4 | 1 | 0 | 84 |
| 39 | RJ HarveyDenver Broncos·#12 | 9 | 88 | 356 | 4.05 | 4 | 213 | 16 | 5 | 25 | 17 | 151 | 3 | 68.0% | 6.04 | 8.88 | 141 | 7 | 5 | 3 | 1 | 251 |
| 40 | Travis EtienneJacksonville Jaguars·#1 | 9 | 128 | 532 | 4.16 | 5 | 330 | 25 | 6 | 25 | 16 | 148 | 3 | 64.0% | 5.92 | 9.25 | 161 | 4 | 3 | 2 | 0 | 327 |
| 41 | Alvin KamaraNew Orleans Saints·#41 | 6 | 59 | 234 | 3.97 | 1 | 172 | 9 | 1 | 23 | 21 | 134 | 0 | 91.3% | 5.83 | 6.38 | 130 | 3 | 2 | 0 | 4 | 221 |
| 42 | Bhayshul TutenJacksonville Jaguars·#33 | 9 | 44 | 183 | 4.16 | 3 | 113 | 15 | 4 | 6 | 4 | 35 | 1 | 66.7% | 5.83 | 8.75 | 25 | 1 | 1 | 1 | 1 | 106 |
| 43 | Ray DavisBuffalo Bills·#22 | 9 | 26 | 161 | 6.19 | 0 | 88 | 8 | 0 | 6 | 4 | 34 | 1 | 66.7% | 5.67 | 8.50 | 47 | 3 | 2 | 1 | 0 | 70 |
| 44 | Josh JacobsGreen Bay Packers·#8 | 7 | 122 | 493 | 4.04 | 7 | 362 | 33 | 7 | 20 | 18 | 113 | 0 | 90.0% | 5.65 | 6.28 | 122 | 3 | 3 | 0 | 3 | 262 |
| 45 | Omarion HamptonLos Angeles Chargers·#8 | 5 | 73 | 247 | 3.38 | 2 | 205 | 15 | 3 | 25 | 24 | 140 | 1 | 96.0% | 5.60 | 5.83 | 186 | 2 | 2 | 1 | 1 | 214 |
| 46 | Ameer AbdullahIndianapolis Colts·#26 | 7 | 5 | 18 | 3.60 | 1 | 10 | 2 | 1 | 5 | 5 | 28 | 0 | 100.0% | 5.60 | 5.60 | 31 | 0 | 0 | 0 | 0 | 29 |
| 47 | Dare OgunbowaleHouston Texans·#33 | 9 | 8 | 11 | 1.38 | 0 | 13 | 0 | 2 | 9 | 7 | 50 | 0 | 77.8% | 5.56 | 7.14 | 37 | 3 | 2 | 0 | 1 | 84 |
| 48 | Rico DowdleCarolina Panthers·#5 | 8 | 126 | 667 | 5.29 | 3 | 411 | 33 | 4 | 26 | 20 | 141 | 1 | 76.9% | 5.42 | 7.05 | 151 | 3 | 2 | 0 | 2 | 258 |
| 49 | Malik DavisDallas Cowboys·#43 | 5 | 23 | 118 | 5.13 | 2 | 35 | 8 | 1 | 3 | 2 | 16 | 0 | 66.7% | 5.33 | 8.00 | 6 | 0 | 0 | 0 | 1 | 73 |
| 50 | David MontgomeryDetroit Lions·#5 | 8 | 67 | 254 | 3.79 | 4 | 148 | 17 | 9 | 15 | 11 | 80 | 0 | 73.3% | 5.33 | 7.27 | 90 | 1 | 0 | 0 | 2 | 164 |