| 1 | Andrew OgletreeIndianapolis Colts·#85 | 15 | 6 | 4 | 27 | 1 | 66.7% | 4.50 | 6.75 | 9 | 23 | 0.5 | 2 | 2 | 1 | 13 | 51 | 5 | 3 | 2 | 0 | 89 |
| 2 | Ben YurosekMinnesota Vikings·#85 | 9 | 3 | 2 | 14 | 0 | 66.7% | 4.67 | 7.00 | 9 | 11 | 0.3 | 0 | 0 | 0 | 3 | 30 | 3 | 1 | 1 | 0 | 39 |
| 3 | Cade StoverHouston Texans·#87 | 9 | 16 | 12 | 76 | 0 | 75.0% | 4.75 | 6.33 | 52 | 26 | 0.4 | 3 | 3 | 0 | 11 | 53 | 14 | 1 | 4 | 0 | 83 |
| 4 | Darren WallerMiami Dolphins·#83 | 9 | 35 | 24 | 283 | 6 | 68.6% | 8.09 | 11.79 | 73 | 320 | 2.1 | 8 | 6 | 6 | 23 | 99 | 30 | 6 | 19 | 0 | 169 |
| 5 | Chris ManhertzNew York Giants·#85 | 16 | 2 | 1 | 7 | 0 | 50.0% | 3.50 | 7.00 | 6 | 1 | 0.2 | 1 | 0 | 0 | 8 | 33 | 2 | 2 | 0 | 0 | 59 |
| 6 | Cole KmetChicago Bears·#85 | 16 | 49 | 30 | 349 | 2 | 61.2% | 7.12 | 11.63 | 149 | 322 | 1.1 | 7 | 3 | 1 | 41 | 241 | 34 | 16 | 17 | 0 | 414 |
| 7 | Charlie KolarBaltimore Ravens·#88 | 17 | 15 | 10 | 142 | 2 | 66.7% | 9.47 | 14.20 | 52 | 106 | 0.9 | 3 | 2 | 2 | 12 | 72 | 12 | 7 | 9 | 0 | 122 |
| 8 | Cameron LatuPhiladelphia Eagles·#36 | 12 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0.0 | 0 | 0 | 0 | 4 | 22 | 0 | 1 | 0 | 0 | 34 |
| 9 | Harrison BryantHouston Texans·#88 | 12 | 6 | 2 | 7 | 0 | 33.3% | 1.17 | 3.50 | 0 | 44 | 0.8 | 0 | 0 | 0 | 7 | 34 | 3 | 1 | 1 | 0 | 74 |
| 10 | Hunter LongJacksonville Jaguars·#84 | 9 | 17 | 12 | 85 | 2 | 70.6% | 5.00 | 7.08 | 31 | 66 | 0.4 | 4 | 3 | 2 | 19 | 94 | 11 | 3 | 5 | 0 | 150 |
| 11 | Ian ThomasLas Vegas Raiders·#80 | 14 | 13 | 13 | 114 | 0 | 100.0% | 8.77 | 8.77 | 72 | 42 | 0.3 | 0 | 0 | 0 | 22 | 86 | 9 | 5 | 5 | 0 | 151 |
| 12 | Grant CalcaterraPhiladelphia Eagles·#81 | 15 | 13 | 9 | 76 | 1 | 69.2% | 5.85 | 8.44 | 31 | 85 | 0.6 | 3 | 2 | 1 | 17 | 90 | 11 | 6 | 4 | 0 | 150 |
| 13 | Eric SaubertSeattle Seahawks·#81 | 11 | 8 | 4 | 33 | 0 | 50.0% | 4.12 | 8.25 | 16 | 28 | 0.3 | 4 | 2 | 0 | 7 | 65 | 7 | 8 | 2 | 0 | 93 |
| 14 | Durham SmytheChicago Bears·#81 | 17 | 6 | 4 | 25 | 0 | 66.7% | 4.17 | 6.25 | 15 | 24 | 0.2 | 0 | 0 | 0 | 9 | 70 | 4 | 4 | 1 | 0 | 111 |
| 15 | Devin CulpTampa Bay Buccaneers·#82 | 9 | 1 | 1 | 6 | 1 | 100.0% | 6.00 | 6.00 | 0 | 6 | 0.2 | 1 | 1 | 1 | 2 | 14 | 1 | 0 | 1 | 0 | 27 |
| 16 | David Martin-RobinsonTennessee Titans·#88 | 11 | 6 | 4 | 30 | 1 | 66.7% | 5.00 | 7.50 | 16 | 23 | 0.7 | 1 | 1 | 1 | 2 | 15 | 5 | 0 | 3 | 0 | 33 |
| 17 | John FitzPatrickGreen Bay Packers·#86 | 15 | 15 | 12 | 72 | 1 | 80.0% | 4.80 | 6.00 | 57 | 24 | 0.2 | 4 | 2 | 1 | 24 | 92 | 6 | 5 | 5 | 0 | 150 |
| 18 | Tanner HudsonCincinnati Bengals·#87 | 12 | 24 | 19 | 168 | 2 | 79.2% | 7.00 | 8.84 | 83 | 119 | 1.0 | 6 | 3 | 2 | 21 | 72 | 20 | 4 | 8 | 0 | 115 |
| 19 | Tip ReimanArizona Cardinals·#87 | 4 | 5 | 3 | 18 | 0 | 60.0% | 3.60 | 6.00 | 7 | 26 | 0.6 | 0 | 0 | 0 | 4 | 26 | 4 | 1 | 1 | 0 | 43 |
| 20 | Pharaoh BrownArizona Cardinals·#49 | 7 | 2 | 2 | 1 | 0 | 100.0% | 0.50 | 0.50 | 0 | 1 | 0.0 | 1 | 1 | 0 | 6 | 24 | 2 | 2 | 0 | 0 | 36 |
| 21 | Ross DwelleyDetroit Lions·#82 | 6 | 5 | 2 | 7 | 0 | 40.0% | 1.40 | 3.50 | 7 | 1 | 0.0 | 3 | 1 | 0 | 1 | 29 | 4 | 0 | 0 | 0 | 41 |
| 22 | Shane ZylstraDetroit Lions·#84 | 5 | 5 | 3 | 20 | 0 | 60.0% | 4.00 | 6.67 | 2 | 37 | 0.4 | 1 | 0 | 0 | 6 | 57 | 5 | 0 | 1 | 0 | 98 |
| 23 | Payne DurhamTampa Bay Buccaneers·#87 | 17 | 4 | 1 | 11 | 0 | 25.0% | 2.75 | 11.00 | 11 | 11 | 0.1 | 1 | 0 | 0 | 15 | 65 | 3 | 8 | 1 | 0 | 110 |
| 24 | Stone SmarttNew York Jets·#84 | 6 | 9 | 7 | 52 | 0 | 77.8% | 5.78 | 7.43 | 27 | 26 | 0.7 | 0 | 0 | 0 | 7 | 31 | 8 | 2 | 3 | 0 | 61 |
| 25 | Mo Alie-CoxIndianapolis Colts·#81 | 17 | 19 | 13 | 117 | 1 | 68.4% | 6.16 | 9.00 | 77 | 76 | 0.5 | 6 | 5 | 1 | 24 | 113 | 12 | 9 | 4 | 0 | 185 |
| 26 | Nate AdkinsDenver Broncos·#45 | 9 | 11 | 6 | 48 | 1 | 54.5% | 4.36 | 8.00 | 26 | 28 | 0.5 | 2 | 1 | 1 | 9 | 50 | 8 | 1 | 3 | 0 | 74 |
| 27 | Michael MayerLas Vegas Raiders·#87 | 13 | 48 | 35 | 328 | 1 | 72.9% | 6.83 | 9.37 | 196 | 218 | 0.9 | 6 | 5 | 1 | 26 | 157 | 32 | 4 | 18 | 0 | 259 |
| 28 | Kylen GransonPhiladelphia Eagles·#83 | 15 | 9 | 7 | 40 | 0 | 77.8% | 4.44 | 5.71 | 13 | 68 | 0.7 | 1 | 1 | 0 | 13 | 57 | 7 | 3 | 3 | 0 | 101 |
| 29 | Keleki LatuBuffalo Bills·#83 | 5 | 4 | 4 | 35 | 0 | 100.0% | 8.75 | 8.75 | 23 | 12 | 0.3 | 0 | 0 | 0 | 9 | 25 | 3 | 2 | 3 | 0 | 40 |
| 30 | Josiah DeguaraArizona Cardinals·#45 | 10 | 5 | 3 | 21 | 1 | 60.0% | 4.20 | 7.00 | 5 | 18 | 0.5 | 1 | 1 | 1 | 11 | 28 | 5 | 1 | 2 | 0 | 51 |
| 31 | Josh WhyleGreen Bay Packers·#81 | 8 | 6 | 5 | 36 | 1 | 83.3% | 6.00 | 7.20 | 21 | 23 | 0.3 | 1 | 1 | 1 | 10 | 56 | 3 | 3 | 2 | 0 | 87 |
| 32 | Josh OliverMinnesota Vikings·#84 | 15 | 20 | 15 | 160 | 4 | 75.0% | 8.00 | 10.67 | 102 | 64 | 0.4 | 7 | 5 | 3 | 20 | 90 | 17 | 5 | 9 | 0 | 156 |
| 33 | Tanner ConnerMiami Dolphins·#48 | 9 | 15 | 9 | 91 | 0 | 60.0% | 6.07 | 10.11 | 39 | 109 | 0.9 | 3 | 1 | 0 | 5 | 76 | 11 | 5 | 3 | 0 | 125 |
| 34 | Will DisslyLos Angeles Chargers·#89 | 9 | 16 | 11 | 97 | 0 | 68.8% | 6.06 | 8.82 | 66 | 72 | 0.7 | 1 | 1 | 0 | 18 | 60 | 12 | 0 | 5 | 0 | 104 |
| 35 | Tyler ConklinLos Angeles Chargers·#83 | 8 | 10 | 7 | 101 | 0 | 70.0% | 10.10 | 14.43 | 57 | 46 | 0.5 | 0 | 0 | 0 | 13 | 48 | 7 | 0 | 3 | 0 | 85 |
| 36 | Tucker FiskLos Angeles Chargers·#42 | 10 | 4 | 2 | 19 | 0 | 50.0% | 4.75 | 9.50 | 21 | 2 | 0.3 | 0 | 0 | 0 | 6 | 42 | 0 | 1 | 1 | 0 | 76 |
| 37 | Tyler HigbeeLos Angeles Rams·#89 | 10 | 36 | 25 | 281 | 3 | 69.4% | 7.81 | 11.24 | 140 | 116 | 0.6 | 8 | 6 | 2 | 32 | 137 | 26 | 9 | 17 | 0 | 202 |
| 38 | Evan EngramDenver Broncos·#1 | 16 | 77 | 50 | 461 | 1 | 64.9% | 5.99 | 9.22 | 302 | 257 | 0.9 | 11 | 7 | 1 | 40 | 251 | 39 | 7 | 19 | 1 | 373 |
| 39 | Johnny MundtJacksonville Jaguars·#86 | 16 | 19 | 9 | 111 | 0 | 47.4% | 5.84 | 12.33 | 76 | 108 | 0.6 | 1 | 0 | 0 | 18 | 115 | 15 | 3 | 6 | 1 | 157 |
| 40 | Jackson HawesBuffalo Bills·#85 | 17 | 19 | 16 | 187 | 3 | 84.2% | 9.84 | 11.69 | 91 | 139 | 1.0 | 3 | 3 | 2 | 11 | 95 | 9 | 1 | 13 | 1 | 141 |
| 41 | Mitchell EvansCarolina Panthers·#84 | 17 | 25 | 19 | 171 | 2 | 76.0% | 6.84 | 9.00 | 108 | 91 | 0.6 | 4 | 2 | 2 | 8 | 96 | 16 | 2 | 9 | 1 | 150 |
| 42 | Luke MusgraveGreen Bay Packers·#88 | 17 | 31 | 24 | 252 | 0 | 77.4% | 8.13 | 10.50 | 69 | 265 | 1.2 | 1 | 0 | 0 | 28 | 135 | 26 | 2 | 11 | 1 | 228 |
| 43 | Sam LaPortaDetroit Lions·#87 | 9 | 49 | 40 | 489 | 3 | 81.6% | 9.98 | 12.22 | 274 | 274 | 1.0 | 6 | 4 | 2 | 22 | 201 | 32 | 5 | 23 | 1 | 275 |
| 44 | Moliki MatavaoNew Orleans Saints·#80 | 5 | 2 | 2 | 10 | 0 | 100.0% | 5.00 | 5.00 | 5 | 5 | 0.1 | 0 | 0 | 0 | 0 | 17 | 0 | 0 | 0 | 1 | 33 |
| 45 | Noah GrayKansas City Chiefs·#83 | 16 | 38 | 21 | 178 | 0 | 55.3% | 4.68 | 8.48 | 107 | 219 | 0.8 | 3 | 1 | 0 | 14 | 167 | 29 | 3 | 9 | 1 | 305 |
| 46 | Pat FreiermuthPittsburgh Steelers·#88 | 17 | 54 | 41 | 486 | 4 | 75.9% | 9.00 | 11.85 | 255 | 296 | 0.9 | 9 | 5 | 3 | 44 | 211 | 37 | 11 | 22 | 1 | 350 |
| 47 | Quintin MorrisJacksonville Jaguars·#80 | 9 | 9 | 6 | 55 | 1 | 66.7% | 6.11 | 9.17 | 21 | 33 | 0.5 | 2 | 1 | 1 | 9 | 52 | 6 | 4 | 4 | 1 | 91 |
| 48 | Terrance FergusonLos Angeles Rams·#18 | 13 | 25 | 11 | 231 | 3 | 44.0% | 9.24 | 21.00 | 40 | 460 | 2.7 | 3 | 1 | 1 | 18 | 114 | 23 | 5 | 9 | 1 | 173 |
| 49 | Drew SampleCincinnati Bengals·#89 | 17 | 20 | 15 | 106 | 1 | 75.0% | 5.30 | 7.07 | 109 | -7 | -0.0 | 1 | 1 | 1 | 38 | 197 | 4 | 8 | 5 | 1 | 290 |
| 50 | Connor HeywardPittsburgh Steelers·#83 | 14 | 4 | 3 | 21 | 1 | 75.0% | 5.25 | 7.00 | 5 | 26 | 0.6 | 2 | 1 | 1 | 2 | 16 | 2 | 0 | 1 | 1 | 43 |