| 1 | Adam TrautmanDenver Broncos·#82 | 15 | 4 | 3 | 19 | 0 | 75.0% | 4.75 | 6.33 | 4 | 15 | 0.4 | 0 | 0 | 0 | 1 | 40 | 3 | 2 | 1 | 0 | 62 |
| 2 | Austin HooperNew England Patriots·#81 | 16 | 3 | 1 | 4 | 0 | 33.3% | 1.33 | 4.00 | 0 | 21 | 0.5 | 0 | 0 | 0 | 3 | 27 | 1 | 2 | 0 | 0 | 48 |
| 3 | Brevyn Spann-FordDallas Cowboys·#89 | 11 | 3 | 2 | 7 | 1 | 66.7% | 2.33 | 3.50 | 2 | 5 | 1.1 | 1 | 1 | 1 | 2 | 15 | 2 | 0 | 1 | 0 | 27 |
| 4 | Brenton StrangeJacksonville Jaguars·#85 | 11 | 12 | 9 | 100 | 0 | 75.0% | 8.33 | 11.11 | 41 | 81 | 1.2 | 2 | 1 | 0 | 7 | 49 | 11 | 0 | 4 | 0 | 77 |
| 5 | Brock BowersLas Vegas Raiders·#89 | 12 | 18 | 14 | 162 | 0 | 77.8% | 9.00 | 11.57 | 102 | 67 | 0.8 | 3 | 2 | 0 | 10 | 56 | 13 | 3 | 9 | 0 | 90 |
| 6 | Brock WrightDetroit Lions·#89 | 10 | 5 | 4 | 41 | 0 | 80.0% | 8.20 | 10.25 | 36 | 8 | 0.2 | 0 | 0 | 0 | 2 | 39 | 5 | 0 | 3 | 0 | 51 |
| 7 | Charlie KolarBaltimore Ravens·#88 | 15 | 6 | 3 | 41 | 1 | 50.0% | 6.83 | 13.67 | 22 | 45 | 1.1 | 2 | 1 | 1 | 6 | 28 | 5 | 3 | 3 | 0 | 42 |
| 8 | Cade OttonTampa Bay Buccaneers·#88 | 16 | 16 | 13 | 116 | 0 | 81.3% | 7.25 | 8.92 | 66 | 50 | 0.5 | 3 | 1 | 0 | 11 | 70 | 12 | 4 | 4 | 0 | 118 |
| 9 | Colston LovelandChicago Bears·#84 | 15 | 16 | 10 | 101 | 1 | 62.5% | 6.31 | 10.10 | 27 | 109 | 1.5 | 3 | 1 | 1 | 10 | 59 | 14 | 4 | 6 | 0 | 89 |
| 10 | Cole KmetChicago Bears·#85 | 15 | 13 | 7 | 88 | 0 | 53.9% | 6.77 | 12.57 | 40 | 87 | 1.2 | 1 | 1 | 0 | 11 | 59 | 7 | 6 | 4 | 0 | 104 |
| 11 | George KittleSan Francisco 49ers·#85 | 10 | 17 | 15 | 137 | 2 | 88.2% | 8.06 | 9.13 | 44 | 89 | 1.1 | 4 | 4 | 2 | 9 | 59 | 15 | 0 | 12 | 0 | 78 |
| 12 | Drew SampleCincinnati Bengals·#89 | 17 | 4 | 3 | 26 | 0 | 75.0% | 6.50 | 8.67 | 25 | 3 | 0.1 | 0 | 0 | 0 | 6 | 41 | 1 | 2 | 1 | 0 | 64 |
| 13 | David NjokuCleveland Browns·#85 | 11 | 13 | 8 | 71 | 1 | 61.5% | 5.46 | 8.88 | 50 | 57 | 0.8 | 3 | 2 | 1 | 7 | 38 | 7 | 2 | 2 | 0 | 67 |
| 14 | Davis AllenLos Angeles Rams·#87 | 16 | 10 | 9 | 99 | 2 | 90.0% | 9.90 | 11.00 | 59 | 41 | 0.6 | 2 | 2 | 2 | 5 | 47 | 7 | 4 | 5 | 0 | 64 |
| 15 | Dalton SchultzHouston Texans·#86 | 16 | 23 | 16 | 142 | 1 | 69.6% | 6.17 | 8.88 | 87 | 115 | 1.4 | 4 | 1 | 1 | 11 | 60 | 16 | 1 | 7 | 0 | 91 |
| 16 | Dalton KincaidBuffalo Bills·#86 | 11 | 12 | 11 | 138 | 1 | 91.7% | 11.50 | 12.55 | 79 | 59 | 1.5 | 3 | 3 | 1 | 5 | 36 | 8 | 1 | 7 | 0 | 51 |
| 17 | Grant CalcaterraPhiladelphia Eagles·#81 | 13 | 4 | 2 | 14 | 0 | 50.0% | 3.50 | 7.00 | 7 | 38 | 1.1 | 0 | 0 | 0 | 5 | 21 | 3 | 2 | 0 | 0 | 35 |
| 18 | Evan EngramDenver Broncos·#1 | 15 | 13 | 8 | 88 | 0 | 61.5% | 6.77 | 11.00 | 65 | 83 | 1.3 | 1 | 0 | 0 | 6 | 50 | 6 | 1 | 2 | 0 | 73 |
| 19 | Eric SaubertSeattle Seahawks·#81 | 11 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 11 | 0.4 | 1 | 0 | 0 | 2 | 14 | 1 | 3 | 0 | 0 | 26 |
| 20 | Durham SmytheChicago Bears·#81 | 14 | 4 | 3 | 23 | 0 | 75.0% | 5.75 | 7.67 | 11 | 21 | 0.7 | 0 | 0 | 0 | 1 | 24 | 3 | 1 | 1 | 0 | 31 |
| 21 | John FitzPatrickGreen Bay Packers·#86 | 11 | 2 | 2 | 9 | 1 | 100.0% | 4.50 | 4.50 | 7 | 2 | 0.1 | 1 | 1 | 1 | 5 | 23 | 1 | 0 | 1 | 0 | 35 |
| 22 | Jeremy RuckertNew York Jets·#89 | 17 | 9 | 7 | 60 | 0 | 77.8% | 6.67 | 8.57 | 25 | 33 | 0.5 | 0 | 0 | 0 | 9 | 45 | 5 | 2 | 3 | 0 | 70 |
| 23 | Johnny MundtJacksonville Jaguars·#86 | 14 | 6 | 3 | 40 | 0 | 50.0% | 6.67 | 13.33 | 31 | 37 | 0.8 | 0 | 0 | 0 | 5 | 38 | 4 | 2 | 2 | 0 | 47 |
| 24 | Josh OliverMinnesota Vikings·#84 | 13 | 5 | 4 | 24 | 1 | 80.0% | 4.80 | 6.00 | 12 | 17 | 0.5 | 2 | 2 | 1 | 3 | 19 | 5 | 1 | 2 | 0 | 37 |
| 25 | Jake FergusonDallas Cowboys·#87 | 16 | 20 | 16 | 108 | 2 | 80.0% | 5.40 | 6.75 | 50 | 91 | 1.1 | 5 | 3 | 2 | 17 | 75 | 15 | 5 | 6 | 0 | 102 |
| 26 | Jake TongesSan Francisco 49ers·#88 | 10 | 8 | 7 | 65 | 1 | 87.5% | 8.12 | 9.29 | 17 | 63 | 1.5 | 1 | 1 | 1 | 8 | 35 | 6 | 4 | 3 | 0 | 42 |
| 27 | Ja'Tavion SandersCarolina Panthers·#0 | 11 | 9 | 8 | 49 | 1 | 88.9% | 5.44 | 6.12 | 19 | 41 | 0.8 | 6 | 5 | 1 | 8 | 32 | 6 | 2 | 2 | 0 | 50 |
| 28 | Jackson HawesBuffalo Bills·#85 | 17 | 6 | 6 | 69 | 0 | 100.0% | 11.50 | 11.50 | 50 | 19 | 0.4 | 1 | 1 | 0 | 2 | 28 | 3 | 0 | 5 | 0 | 43 |
| 29 | Ian ThomasLas Vegas Raiders·#80 | 13 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 9 | -4 | -0.1 | 0 | 0 | 0 | 4 | 21 | 0 | 1 | 0 | 0 | 34 |
| 30 | Hunter LongJacksonville Jaguars·#84 | 6 | 2 | 1 | 11 | 0 | 50.0% | 5.50 | 11.00 | 4 | 3 | 0.1 | 0 | 0 | 0 | 2 | 16 | 0 | 0 | 1 | 0 | 28 |
| 31 | Hunter HenryNew England Patriots·#85 | 17 | 19 | 13 | 193 | 2 | 68.4% | 10.16 | 14.85 | 123 | 129 | 1.1 | 4 | 3 | 1 | 19 | 83 | 12 | 8 | 7 | 0 | 127 |
| 32 | Gunnar HelmTennessee Titans·#84 | 16 | 6 | 6 | 42 | 0 | 100.0% | 7.00 | 7.00 | 10 | 32 | 0.6 | 0 | 0 | 0 | 6 | 27 | 2 | 1 | 2 | 0 | 54 |
| 33 | Noah GrayKansas City Chiefs·#83 | 15 | 7 | 5 | 51 | 0 | 71.4% | 7.29 | 10.20 | 34 | 24 | 0.3 | 1 | 0 | 0 | 3 | 42 | 6 | 1 | 3 | 0 | 72 |
| 34 | Noah FantCincinnati Bengals·#86 | 14 | 6 | 5 | 39 | 0 | 83.3% | 6.50 | 7.80 | 40 | -4 | -0.1 | 1 | 0 | 0 | 6 | 34 | 2 | 1 | 2 | 0 | 44 |
| 35 | Oronde Gadsden IILos Angeles Chargers·#86 | 15 | 18 | 14 | 204 | 1 | 77.8% | 11.33 | 14.57 | 78 | 142 | 1.5 | 6 | 3 | 1 | 12 | 57 | 14 | 1 | 8 | 0 | 97 |
| 36 | Mason TaylorNew York Jets·#85 | 12 | 18 | 13 | 135 | 0 | 72.2% | 7.50 | 10.38 | 62 | 122 | 1.6 | 1 | 1 | 0 | 16 | 50 | 16 | 2 | 8 | 0 | 82 |
| 37 | Mo Alie-CoxIndianapolis Colts·#81 | 16 | 4 | 4 | 24 | 1 | 100.0% | 6.00 | 6.00 | 15 | 9 | 0.2 | 3 | 3 | 1 | 7 | 32 | 1 | 2 | 1 | 0 | 52 |
| 38 | Mike GesickiCincinnati Bengals·#88 | 11 | 9 | 4 | 60 | 0 | 44.4% | 6.67 | 15.00 | 5 | 124 | 3.2 | 1 | 0 | 0 | 9 | 30 | 7 | 0 | 4 | 0 | 45 |
| 39 | Michael MayerLas Vegas Raiders·#87 | 11 | 11 | 11 | 139 | 0 | 100.0% | 12.64 | 12.64 | 89 | 50 | 0.9 | 1 | 1 | 0 | 2 | 36 | 7 | 1 | 7 | 0 | 56 |
| 40 | Josh WhyleGreen Bay Packers·#81 | 7 | 1 | 1 | 2 | 1 | 100.0% | 2.00 | 2.00 | 0 | 2 | 0.1 | 1 | 1 | 1 | 4 | 16 | 1 | 1 | 1 | 0 | 27 |
| 41 | Luke MusgraveGreen Bay Packers·#88 | 13 | 7 | 6 | 75 | 0 | 85.7% | 10.71 | 12.50 | 18 | 73 | 1.5 | 0 | 0 | 0 | 3 | 30 | 7 | 0 | 4 | 0 | 48 |
| 42 | Luke SchoonmakerDallas Cowboys·#86 | 15 | 5 | 2 | 43 | 0 | 40.0% | 8.60 | 21.50 | 33 | 58 | 1.2 | 0 | 0 | 0 | 6 | 32 | 3 | 1 | 2 | 0 | 50 |
| 43 | Julian HillMiami Dolphins·#89 | 13 | 3 | 2 | 15 | 0 | 66.7% | 5.00 | 7.50 | 18 | -3 | 0.1 | 0 | 0 | 0 | 5 | 27 | 2 | 0 | 1 | 0 | 48 |
| 44 | Terrance FergusonLos Angeles Rams·#18 | 12 | 4 | 1 | 27 | 1 | 25.0% | 6.75 | 27.00 | 0 | 67 | 1.5 | 1 | 0 | 0 | 7 | 31 | 3 | 2 | 1 | 0 | 50 |
| 45 | Tanner ConnerMiami Dolphins·#48 | 8 | 5 | 3 | 48 | 0 | 60.0% | 9.60 | 16.00 | 20 | 41 | 1.5 | 0 | 0 | 0 | 0 | 19 | 3 | 1 | 1 | 0 | 30 |
| 46 | Sam LaPortaDetroit Lions·#87 | 9 | 11 | 10 | 127 | 0 | 90.9% | 11.55 | 12.70 | 74 | 53 | 0.9 | 1 | 1 | 0 | 6 | 47 | 6 | 0 | 5 | 0 | 61 |
| 47 | Payne DurhamTampa Bay Buccaneers·#87 | 13 | 1 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 0 | 0.2 | 0 | 0 | 0 | 7 | 15 | 0 | 5 | 0 | 0 | 31 |
| 48 | Pat FreiermuthPittsburgh Steelers·#88 | 16 | 15 | 10 | 94 | 1 | 66.7% | 6.27 | 9.40 | 51 | 83 | 1.4 | 5 | 2 | 1 | 9 | 37 | 10 | 1 | 5 | 0 | 65 |
| 49 | Tommy TrembleCarolina Panthers·#82 | 17 | 9 | 7 | 45 | 0 | 77.8% | 5.00 | 6.43 | 27 | 31 | 0.4 | 1 | 0 | 0 | 3 | 44 | 6 | 0 | 2 | 0 | 71 |
| 50 | Travis KelceKansas City Chiefs·#87 | 17 | 23 | 20 | 239 | 1 | 87.0% | 10.39 | 11.95 | 143 | 137 | 0.9 | 1 | 1 | 1 | 10 | 91 | 18 | 1 | 11 | 0 | 141 |