| 1 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 164 | 713 | 4.35 | 2 | 553 | 28 | 0 | 46 | 32 | 239 | 1 | 69.6% | 5.20 | 7.47 | 295 | 0 | 0 | 0 | 1 | 432 |
| 2 | Dylan SampsonCleveland Browns·#22 | 15 | 41 | 87 | 2.12 | 0 | 119 | 8 | 0 | 23 | 19 | 150 | 1 | 82.6% | 6.52 | 7.89 | 204 | 0 | 0 | 0 | 2 | 143 |
| 3 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 88 | 353 | 4.01 | 0 | 226 | 15 | 0 | 23 | 19 | 201 | 1 | 82.6% | 8.74 | 10.58 | 257 | 0 | 0 | 0 | 1 | 225 |
| 4 | D'Andre SwiftChicago Bears·#4 | 16 | 105 | 567 | 5.40 | 0 | 271 | 25 | 0 | 29 | 19 | 183 | 1 | 65.5% | 6.31 | 9.63 | 188 | 0 | 0 | 0 | 2 | 286 |
| 5 | Ty JohnsonBuffalo Bills·#26 | 17 | 10 | 36 | 3.60 | 0 | 53 | 1 | 0 | 15 | 12 | 123 | 1 | 80.0% | 8.20 | 10.25 | 159 | 0 | 0 | 0 | 1 | 139 |
| 6 | Austin EkelerWashington Commanders·#30 | 2 | 7 | 22 | 3.14 | 0 | 19 | 0 | 0 | 3 | 3 | 11 | 0 | 100.0% | 3.67 | 3.67 | 19 | 0 | 0 | 0 | 0 | 35 |
| 7 | Bam KnightArizona Cardinals·#20 | 10 | 38 | 122 | 3.21 | 0 | 122 | 7 | 0 | 15 | 11 | 90 | 0 | 73.3% | 6.00 | 8.18 | 91 | 0 | 0 | 0 | 2 | 141 |
| 8 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 5 | 30 | 6.00 | 0 | 16 | 2 | 0 | 9 | 9 | 49 | 0 | 100.0% | 5.44 | 5.44 | 53 | 0 | 0 | 0 | 0 | 32 |
| 9 | Aaron JonesMinnesota Vikings·#33 | 12 | 79 | 338 | 4.28 | 0 | 223 | 14 | 0 | 25 | 16 | 118 | 0 | 64.0% | 4.72 | 7.38 | 152 | 0 | 0 | 0 | 2 | 209 |
| 10 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 162 | 994 | 6.14 | 2 | 717 | 40 | 0 | 56 | 43 | 497 | 0 | 76.8% | 8.88 | 11.56 | 492 | 0 | 0 | 0 | 3 | 455 |
| 11 | Blake CorumLos Angeles Rams·#22 | 17 | 60 | 332 | 5.53 | 0 | 168 | 19 | 0 | 11 | 7 | 42 | 0 | 63.6% | 3.82 | 6.00 | 36 | 0 | 0 | 0 | 0 | 141 |
| 12 | Breece HallNew York Jets·#20 | 16 | 148 | 691 | 4.67 | 1 | 310 | 34 | 0 | 26 | 22 | 203 | 0 | 84.6% | 7.81 | 9.23 | 177 | 0 | 0 | 0 | 1 | 355 |
| 13 | Brashard SmithKansas City Chiefs·#24 | 17 | 23 | 65 | 2.83 | 0 | 66 | 2 | 0 | 13 | 8 | 62 | 0 | 61.5% | 4.77 | 7.75 | 85 | 0 | 0 | 0 | 0 | 73 |
| 14 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 24 | 111 | 4.62 | 0 | 57 | 5 | 0 | 3 | 3 | 12 | 0 | 100.0% | 4.00 | 4.00 | 12 | 0 | 0 | 0 | 0 | 45 |
| 15 | Cam SkatteboNew York Giants·#44 | 8 | 56 | 249 | 4.45 | 0 | 183 | 13 | 0 | 16 | 11 | 98 | 0 | 68.8% | 6.12 | 8.91 | 105 | 0 | 0 | 0 | 0 | 142 |
| 16 | Bhayshul TutenJacksonville Jaguars·#33 | 14 | 27 | 125 | 4.63 | 0 | 81 | 8 | 0 | 10 | 7 | 50 | 0 | 70.0% | 5.00 | 7.14 | 54 | 0 | 0 | 0 | 0 | 80 |
| 17 | Alvin KamaraNew Orleans Saints·#41 | 11 | 74 | 277 | 3.74 | 0 | 188 | 10 | 0 | 17 | 15 | 130 | 0 | 88.2% | 7.65 | 8.67 | 127 | 0 | 0 | 0 | 3 | 218 |
| 18 | Chris BrooksGreen Bay Packers·#30 | 16 | 13 | 63 | 4.85 | 0 | 43 | 3 | 0 | 7 | 6 | 31 | 0 | 85.7% | 4.43 | 5.17 | 33 | 0 | 0 | 0 | 0 | 81 |
| 19 | Chase BrownCincinnati Bengals·#30 | 17 | 126 | 615 | 4.88 | 0 | 421 | 23 | 0 | 45 | 37 | 255 | 0 | 82.2% | 5.67 | 6.89 | 270 | 0 | 0 | 0 | 3 | 362 |
| 20 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 119 | 531 | 4.46 | 0 | 364 | 22 | 0 | 69 | 56 | 575 | 0 | 81.2% | 8.33 | 10.27 | 464 | 0 | 0 | 0 | 3 | 410 |
| 21 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 49 | 266 | 5.43 | 0 | 185 | 12 | 0 | 2 | 2 | 12 | 0 | 100.0% | 6.00 | 6.00 | 9 | 0 | 0 | 0 | 1 | 102 |
| 22 | DJ GiddensIndianapolis Colts·#21 | 6 | 10 | 42 | 4.20 | 0 | 27 | 2 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 26 |
| 23 | Dare OgunbowaleHouston Texans·#33 | 13 | 2 | 4 | 2.00 | 0 | 8 | 0 | 0 | 3 | 2 | 4 | 0 | 66.7% | 1.33 | 2.00 | 3 | 0 | 0 | 0 | 0 | 47 |
| 24 | David MontgomeryDetroit Lions·#5 | 17 | 61 | 273 | 4.48 | 0 | 196 | 9 | 0 | 15 | 12 | 93 | 0 | 80.0% | 6.20 | 7.75 | 105 | 0 | 0 | 0 | 3 | 164 |
| 25 | Chuba HubbardCarolina Panthers·#30 | 14 | 72 | 299 | 4.15 | 0 | 168 | 16 | 0 | 12 | 10 | 62 | 0 | 83.3% | 5.17 | 6.20 | 75 | 0 | 0 | 0 | 2 | 192 |
| 26 | De'Von AchaneMiami Dolphins·#28 | 16 | 131 | 669 | 5.11 | 1 | 406 | 26 | 0 | 47 | 38 | 246 | 0 | 80.8% | 5.23 | 6.47 | 294 | 0 | 0 | 0 | 3 | 369 |
| 27 | Derrick HenryBaltimore Ravens·#22 | 17 | 156 | 909 | 5.83 | 0 | 559 | 40 | 0 | 8 | 6 | 69 | 0 | 75.0% | 8.62 | 11.50 | 72 | 0 | 0 | 0 | 3 | 272 |
| 28 | Devin NealNew Orleans Saints·#24 | 9 | 25 | 72 | 2.88 | 0 | 37 | 1 | 0 | 7 | 6 | 36 | 0 | 85.7% | 5.14 | 6.00 | 53 | 0 | 0 | 0 | 0 | 122 |
| 29 | Devin SingletaryNew York Giants·#26 | 16 | 48 | 147 | 3.06 | 0 | 117 | 5 | 0 | 10 | 9 | 81 | 0 | 90.0% | 8.10 | 9.00 | 102 | 0 | 0 | 0 | 0 | 115 |
| 30 | Emanuel WilsonGreen Bay Packers·#23 | 15 | 54 | 214 | 3.96 | 0 | 209 | 12 | 0 | 11 | 11 | 93 | 0 | 100.0% | 8.45 | 8.45 | 110 | 0 | 0 | 0 | 0 | 132 |
| 31 | Emari DemercadoArizona Cardinals·#31 | 11 | 21 | 218 | 10.38 | 0 | 89 | 4 | 0 | 8 | 6 | 67 | 0 | 75.0% | 8.38 | 11.17 | 50 | 0 | 0 | 0 | 3 | 94 |
| 32 | Evan HullNew Orleans Saints·#34 | 6 | 9 | 23 | 2.56 | 0 | 11 | 2 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 0 | 33 |
| 33 | Audric EstiméNew Orleans Saints·#30 | 5 | 29 | 122 | 4.21 | 0 | 124 | 8 | 0 | 10 | 10 | 87 | 0 | 100.0% | 8.70 | 8.70 | 89 | 0 | 0 | 0 | 0 | 91 |
| 34 | Hassan HaskinsLos Angeles Chargers·#28 | 6 | 6 | 18 | 3.00 | 0 | 11 | 2 | 0 | 4 | 4 | 13 | 0 | 100.0% | 3.25 | 3.25 | 16 | 0 | 0 | 0 | 1 | 33 |
| 35 | Isaiah DavisNew York Jets·#32 | 16 | 13 | 120 | 9.23 | 0 | 98 | 3 | 0 | 17 | 13 | 115 | 0 | 76.5% | 6.76 | 8.85 | 137 | 0 | 0 | 0 | 1 | 132 |
| 36 | J.K. DobbinsDenver Broncos·#27 | 10 | 88 | 439 | 4.99 | 0 | 232 | 20 | 0 | 7 | 7 | 17 | 0 | 100.0% | 2.43 | 2.43 | 34 | 0 | 0 | 0 | 1 | 194 |
| 37 | Isiah PachecoKansas City Chiefs·#10 | 13 | 65 | 273 | 4.20 | 0 | 182 | 18 | 0 | 18 | 14 | 81 | 0 | 77.8% | 4.50 | 5.79 | 99 | 0 | 0 | 0 | 0 | 205 |
| 38 | Jahmyr GibbsDetroit Lions·#0 | 17 | 116 | 739 | 6.37 | 2 | 373 | 25 | 0 | 48 | 37 | 320 | 0 | 77.1% | 6.67 | 8.65 | 335 | 0 | 0 | 0 | 1 | 351 |
| 39 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 19 | 88 | 4.63 | 0 | 61 | 3 | 0 | 6 | 4 | 27 | 0 | 66.7% | 4.50 | 6.75 | 39 | 0 | 0 | 0 | 1 | 46 |
| 40 | James ConnerArizona Cardinals·#6 | 3 | 23 | 61 | 2.65 | 0 | 70 | 5 | 0 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 62 | 0 | 0 | 0 | 0 | 60 |
| 41 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 92 | 516 | 5.61 | 1 | 334 | 21 | 0 | 8 | 5 | 43 | 0 | 62.5% | 5.38 | 8.60 | 41 | 0 | 0 | 0 | 1 | 210 |
| 42 | Jaret PattersonLos Angeles Chargers·#32 | 6 | 19 | 72 | 3.79 | 0 | 45 | 3 | 0 | 3 | 2 | 4 | 0 | 66.7% | 1.33 | 2.00 | 5 | 0 | 0 | 0 | 1 | 52 |
| 43 | Javonte WilliamsDallas Cowboys·#33 | 16 | 126 | 610 | 4.84 | 0 | 387 | 24 | 0 | 30 | 22 | 82 | 0 | 73.3% | 2.73 | 3.73 | 122 | 0 | 0 | 0 | 2 | 380 |
| 44 | Jawhar JordanHouston Texans·#26 | 4 | 20 | 117 | 5.85 | 0 | 86 | 4 | 0 | 3 | 3 | 8 | 0 | 100.0% | 2.67 | 2.67 | 17 | 0 | 0 | 0 | 0 | 36 |
| 45 | Jaydon BlueDallas Cowboys·#23 | 5 | 21 | 59 | 2.81 | 0 | 27 | 3 | 0 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 0 | 38 |
| 46 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 111 | 477 | 4.30 | 0 | 383 | 25 | 0 | 25 | 22 | 182 | 0 | 88.0% | 7.28 | 8.27 | 242 | 0 | 0 | 0 | 1 | 244 |
| 47 | Jaylen WrightMiami Dolphins·#5 | 9 | 32 | 145 | 4.53 | 0 | 118 | 5 | 0 | 6 | 3 | 31 | 0 | 50.0% | 5.17 | 10.33 | 42 | 0 | 0 | 0 | 0 | 56 |
| 48 | Jeremy McNicholsWashington Commanders·#26 | 17 | 22 | 127 | 5.77 | 1 | 130 | 4 | 0 | 16 | 12 | 101 | 0 | 75.0% | 6.31 | 8.42 | 109 | 0 | 0 | 0 | 0 | 136 |
| 49 | James CookBuffalo Bills·#4 | 17 | 153 | 868 | 5.67 | 1 | 543 | 35 | 0 | 26 | 22 | 195 | 0 | 84.6% | 7.50 | 8.86 | 180 | 0 | 0 | 0 | 2 | 310 |
| 50 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 145 | 857 | 5.91 | 2 | 561 | 36 | 0 | 34 | 29 | 215 | 0 | 85.3% | 6.32 | 7.41 | 251 | 0 | 0 | 0 | 3 | 419 |