| 1 | Derrick HenryBaltimore Ravens·#22 | 13 | 125 | 746 | 5.97 | 6 | 402 | 33 | 8 | 5 | 4 | 39 | 0 | 80.0% | 7.80 | 9.75 | 38 | 0 | 0 | 0 | 2 | 191 |
| 2 | James CookBuffalo Bills·#4 | 12 | 121 | 686 | 5.67 | 4 | 391 | 24 | 7 | 11 | 9 | 90 | 0 | 81.8% | 8.18 | 10.00 | 101 | 2 | 2 | 0 | 0 | 193 |
| 3 | Bijan RobinsonAtlanta Falcons·#7 | 12 | 105 | 646 | 6.15 | 3 | 500 | 22 | 3 | 33 | 26 | 308 | 0 | 78.8% | 9.33 | 11.85 | 321 | 6 | 4 | 0 | 1 | 263 |
| 4 | Jonathan TaylorIndianapolis Colts·#28 | 13 | 122 | 636 | 5.21 | 11 | 308 | 37 | 12 | 25 | 19 | 122 | 1 | 76.0% | 4.88 | 6.42 | 167 | 4 | 3 | 1 | 1 | 314 |
| 5 | TreVeyon HendersonNew England Patriots·#32 | 15 | 118 | 610 | 5.17 | 5 | 249 | 29 | 5 | 24 | 20 | 128 | 1 | 83.3% | 5.33 | 6.40 | 150 | 3 | 3 | 1 | 2 | 265 |
| 6 | Kyren WilliamsLos Angeles Rams·#23 | 14 | 126 | 589 | 4.67 | 2 | 369 | 32 | 6 | 12 | 8 | 53 | 1 | 66.7% | 4.42 | 6.62 | 31 | 1 | 1 | 1 | 2 | 299 |
| 7 | Jahmyr GibbsDetroit Lions·#0 | 10 | 85 | 560 | 6.59 | 6 | 214 | 26 | 1 | 19 | 17 | 175 | 2 | 89.5% | 9.21 | 10.29 | 175 | 3 | 2 | 2 | 1 | 202 |
| 8 | Christian McCaffreySan Francisco 49ers·#23 | 12 | 141 | 535 | 3.79 | 5 | 299 | 29 | 11 | 41 | 34 | 309 | 4 | 82.9% | 7.54 | 9.09 | 253 | 9 | 9 | 4 | 4 | 352 |
| 9 | Saquon BarkleyPhiladelphia Eagles·#26 | 14 | 145 | 521 | 3.59 | 3 | 370 | 26 | 4 | 21 | 16 | 195 | 1 | 76.2% | 9.29 | 12.19 | 195 | 1 | 1 | 0 | 0 | 326 |
| 10 | De'Von AchaneMiami Dolphins·#28 | 11 | 101 | 516 | 5.11 | 4 | 329 | 25 | 1 | 23 | 19 | 135 | 1 | 82.6% | 5.87 | 7.11 | 150 | 6 | 3 | 1 | 1 | 230 |
| 11 | Kenneth Walker IIISeattle Seahawks·#9 | 14 | 113 | 497 | 4.40 | 3 | 284 | 27 | 5 | 17 | 14 | 85 | 0 | 82.3% | 5.00 | 6.07 | 119 | 1 | 1 | 0 | 4 | 215 |
| 12 | Travis EtienneJacksonville Jaguars·#1 | 15 | 129 | 492 | 3.81 | 4 | 336 | 19 | 6 | 21 | 12 | 139 | 4 | 57.1% | 6.62 | 11.58 | 149 | 6 | 4 | 3 | 0 | 277 |
| 13 | D'Andre SwiftChicago Bears·#4 | 10 | 83 | 463 | 5.58 | 2 | 236 | 24 | 3 | 9 | 5 | 31 | 0 | 55.6% | 3.44 | 6.20 | 48 | 0 | 0 | 0 | 0 | 196 |
| 14 | Blake CorumLos Angeles Rams·#22 | 14 | 82 | 420 | 5.12 | 4 | 177 | 25 | 5 | 6 | 5 | 19 | 0 | 83.3% | 3.17 | 3.80 | 22 | 0 | 0 | 0 | 0 | 170 |
| 15 | Zach CharbonnetSeattle Seahawks·#26 | 13 | 106 | 391 | 3.69 | 6 | 302 | 26 | 8 | 12 | 10 | 83 | 0 | 83.3% | 6.92 | 8.30 | 81 | 2 | 2 | 0 | 3 | 217 |
| 16 | J.K. DobbinsDenver Broncos·#27 | 8 | 66 | 360 | 5.45 | 2 | 188 | 19 | 4 | 7 | 5 | 31 | 0 | 71.4% | 4.43 | 6.20 | 30 | 0 | 0 | 0 | 0 | 129 |
| 17 | Woody MarksHouston Texans·#27 | 11 | 97 | 359 | 3.70 | 1 | 229 | 19 | 1 | 22 | 16 | 117 | 2 | 72.7% | 5.32 | 7.31 | 129 | 5 | 4 | 2 | 0 | 239 |
| 18 | Josh JacobsGreen Bay Packers·#8 | 10 | 85 | 356 | 4.19 | 5 | 263 | 17 | 8 | 15 | 12 | 126 | 0 | 80.0% | 8.40 | 10.50 | 127 | 0 | 0 | 0 | 2 | 189 |
| 19 | Javonte WilliamsDallas Cowboys·#33 | 8 | 61 | 356 | 5.84 | 2 | 212 | 16 | 3 | 7 | 4 | 5 | 1 | 57.1% | 0.71 | 1.25 | 16 | 3 | 3 | 1 | 0 | 145 |
| 20 | Kyle MonangaiChicago Bears·#25 | 11 | 73 | 354 | 4.85 | 3 | 189 | 19 | 4 | 7 | 4 | 31 | 0 | 57.1% | 4.43 | 7.75 | 32 | 1 | 1 | 0 | 0 | 175 |
| 21 | David MontgomeryDetroit Lions·#5 | 10 | 76 | 344 | 4.53 | 3 | 179 | 18 | 7 | 9 | 7 | 54 | 0 | 77.8% | 6.00 | 7.71 | 57 | 0 | 0 | 0 | 2 | 173 |
| 22 | Kenneth GainwellPittsburgh Steelers·#14 | 16 | 64 | 331 | 5.17 | 2 | 235 | 24 | 2 | 35 | 32 | 218 | 1 | 91.4% | 6.23 | 6.81 | 236 | 9 | 7 | 1 | 1 | 188 |
| 23 | Kimani VidalLos Angeles Chargers·#30 | 9 | 80 | 328 | 4.10 | 2 | 152 | 20 | 5 | 5 | 3 | 30 | 1 | 60.0% | 6.00 | 10.00 | 36 | 2 | 1 | 1 | 0 | 181 |
| 24 | Chase BrownCincinnati Bengals·#30 | 10 | 72 | 305 | 4.24 | 4 | 270 | 15 | 3 | 20 | 18 | 148 | 4 | 90.0% | 7.40 | 8.22 | 138 | 7 | 6 | 4 | 0 | 172 |
| 25 | Jordan MasonMinnesota Vikings·#27 | 8 | 58 | 302 | 5.21 | 3 | 174 | 16 | 3 | 0 | 0 | 0 | 0 | — | — | — | 0 | 0 | 0 | 0 | 1 | 114 |
| 26 | Tyrone Tracy Jr.New York Giants·#29 | 8 | 60 | 302 | 5.03 | 1 | 186 | 15 | 2 | 15 | 10 | 122 | 1 | 66.7% | 8.13 | 12.20 | 122 | 4 | 3 | 1 | 2 | 155 |
| 27 | Emanuel WilsonGreen Bay Packers·#23 | 11 | 65 | 298 | 4.58 | 1 | 206 | 19 | 2 | 7 | 5 | 46 | 0 | 71.4% | 6.57 | 9.20 | 58 | 2 | 0 | 0 | 0 | 119 |
| 28 | Jaylen WarrenPittsburgh Steelers·#30 | 14 | 69 | 298 | 4.32 | 3 | 184 | 15 | 2 | 18 | 17 | 117 | 1 | 94.4% | 6.50 | 6.88 | 163 | 1 | 1 | 0 | 2 | 167 |
| 29 | Jacory Croskey-MerrittWashington Commanders·#22 | 7 | 48 | 273 | 5.69 | 3 | 197 | 16 | 2 | 2 | 1 | 5 | 0 | 50.0% | 2.50 | 5.00 | 11 | 0 | 0 | 0 | 1 | 92 |
| 30 | Tyler AllgeierAtlanta Falcons·#25 | 10 | 80 | 267 | 3.34 | 3 | 220 | 19 | 4 | 6 | 5 | 20 | 0 | 83.3% | 3.33 | 4.00 | 31 | 1 | 1 | 0 | 1 | 126 |
| 31 | Rhamondre StevensonNew England Patriots·#38 | 13 | 70 | 258 | 3.69 | 5 | 159 | 14 | 8 | 21 | 19 | 178 | 2 | 90.5% | 8.48 | 9.37 | 146 | 4 | 4 | 1 | 0 | 245 |
| 32 | Nick ChubbHouston Texans·#21 | 11 | 59 | 242 | 4.10 | 1 | 171 | 9 | 2 | 6 | 4 | 23 | 0 | 66.7% | 3.83 | 5.75 | 11 | 0 | 0 | 0 | 0 | 125 |
| 33 | Tony PollardTennessee Titans·#20 | 7 | 47 | 239 | 5.09 | 1 | 138 | 6 | 0 | 2 | 2 | 17 | 0 | 100.0% | 8.50 | 8.50 | 19 | 0 | 0 | 0 | 1 | 84 |
| 34 | Rico DowdleCarolina Panthers·#5 | 9 | 59 | 234 | 3.97 | 2 | 130 | 14 | 3 | 5 | 3 | 33 | 0 | 60.0% | 6.60 | 11.00 | 38 | 0 | 0 | 0 | 0 | 94 |
| 35 | Rachaad WhiteTampa Bay Buccaneers·#1 | 13 | 49 | 233 | 4.76 | 1 | 128 | 8 | 2 | 13 | 13 | 96 | 0 | 100.0% | 7.38 | 7.38 | 143 | 3 | 3 | 0 | 1 | 165 |
| 36 | Bucky IrvingTampa Bay Buccaneers·#7 | 8 | 76 | 233 | 3.07 | 1 | 131 | 11 | 0 | 9 | 8 | 39 | 0 | 88.9% | 4.33 | 4.88 | 66 | 1 | 1 | 0 | 0 | 139 |
| 37 | Isiah PachecoKansas City Chiefs·#10 | 9 | 48 | 220 | 4.58 | 1 | 144 | 13 | 0 | 6 | 3 | 10 | 1 | 50.0% | 1.67 | 3.33 | 15 | 2 | 2 | 1 | 0 | 140 |
| 38 | Cam SkatteboNew York Giants·#44 | 5 | 58 | 217 | 3.74 | 2 | 155 | 14 | 7 | 12 | 8 | 68 | 1 | 66.7% | 5.67 | 8.50 | 81 | 2 | 1 | 1 | 0 | 125 |
| 39 | Tank BigsbyPhiladelphia Eagles·#37 | 9 | 35 | 210 | 6.00 | 0 | 153 | 10 | 4 | 3 | 2 | 1 | 0 | 66.7% | 0.33 | 0.50 | 9 | 1 | 1 | 0 | 0 | 61 |
| 40 | Ray DavisBuffalo Bills·#22 | 10 | 43 | 207 | 4.81 | 0 | 125 | 9 | 2 | 4 | 2 | 23 | 1 | 50.0% | 5.75 | 11.50 | 29 | 2 | 1 | 1 | 0 | 82 |
| 41 | Aaron JonesMinnesota Vikings·#33 | 8 | 43 | 197 | 4.58 | 0 | 119 | 10 | 0 | 7 | 4 | 25 | 0 | 57.1% | 3.57 | 6.25 | 40 | 1 | 1 | 0 | 1 | 84 |
| 42 | RJ HarveyDenver Broncos·#12 | 14 | 64 | 196 | 3.06 | 3 | 141 | 11 | 5 | 21 | 15 | 107 | 2 | 71.4% | 5.10 | 7.13 | 117 | 6 | 5 | 2 | 0 | 164 |
| 43 | Brian RobinsonSan Francisco 49ers·#3 | 10 | 50 | 190 | 3.80 | 1 | 100 | 10 | 0 | 4 | 2 | 3 | 0 | 50.0% | 0.75 | 1.50 | 8 | 1 | 0 | 0 | 0 | 79 |
| 44 | Samaje PerineCincinnati Bengals·#34 | 9 | 32 | 186 | 5.81 | 2 | 133 | 14 | 2 | 2 | 2 | 14 | 0 | 100.0% | 7.00 | 7.00 | 21 | 0 | 0 | 0 | 1 | 98 |
| 45 | Jawhar JordanHouston Texans·#26 | 4 | 33 | 183 | 5.55 | 0 | 114 | 8 | 1 | 5 | 5 | 28 | 0 | 100.0% | 5.60 | 5.60 | 30 | 0 | 0 | 0 | 0 | 57 |
| 46 | Ashton JeantyLas Vegas Raiders·#2 | 7 | 48 | 180 | 3.75 | 1 | 187 | 7 | 1 | 8 | 5 | 21 | 0 | 62.5% | 2.62 | 4.20 | 45 | 0 | 0 | 0 | 0 | 106 |
| 47 | Omarion HamptonLos Angeles Chargers·#8 | 7 | 53 | 178 | 3.36 | 2 | 163 | 13 | 5 | 12 | 10 | 49 | 0 | 83.3% | 4.08 | 4.90 | 62 | 0 | 0 | 0 | 2 | 132 |
| 48 | Bhayshul TutenJacksonville Jaguars·#33 | 12 | 47 | 172 | 3.66 | 2 | 128 | 13 | 2 | 6 | 5 | 55 | 1 | 83.3% | 9.17 | 11.00 | 42 | 1 | 1 | 1 | 1 | 103 |
| 49 | Jaylen WrightMiami Dolphins·#5 | 5 | 39 | 165 | 4.23 | 1 | 109 | 10 | 1 | 4 | 1 | 0 | 0 | 25.0% | 0.00 | 0.00 | 3 | 0 | 0 | 0 | 0 | 48 |
| 50 | Emari DemercadoArizona Cardinals·#31 | 3 | 18 | 164 | 9.11 | 0 | 30 | 4 | 0 | 1 | 1 | -1 | 0 | 100.0% | -1.00 | -1.00 | 0 | 0 | 0 | 0 | 1 | 41 |