| 1 | Emari DemercadoArizona Cardinals·#31 | 11 | 44 | 312 | 7.09 | 0 | 133 | 9 | 0 | 20 | 13 | 101 | 1 | 65.0% | 5.05 | 7.77 | 84 | 4 | 3 | 1 | 3 | 180 |
| 2 | Isaiah DavisNew York Jets·#32 | 16 | 42 | 237 | 5.64 | 1 | 165 | 9 | 0 | 29 | 21 | 188 | 0 | 72.4% | 6.48 | 8.95 | 189 | 2 | 1 | 0 | 2 | 261 |
| 3 | De'Von AchaneMiami Dolphins·#28 | 16 | 240 | 1,350 | 5.62 | 8 | 822 | 58 | 5 | 84 | 67 | 481 | 4 | 79.8% | 5.73 | 7.18 | 545 | 11 | 7 | 3 | 3 | 658 |
| 4 | Keaton MitchellBaltimore Ravens·#34 | 13 | 61 | 341 | 5.59 | 1 | 184 | 16 | 0 | 12 | 9 | 63 | 0 | 75.0% | 5.25 | 7.00 | 85 | 0 | 0 | 0 | 1 | 120 |
| 5 | Miles SandersDallas Cowboys·#24 | 4 | 21 | 117 | 5.57 | 1 | 76 | 7 | 1 | 8 | 8 | 30 | 0 | 100.0% | 3.75 | 3.75 | 44 | 1 | 1 | 0 | 1 | 63 |
| 6 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 56 | 306 | 5.46 | 1 | 220 | 16 | 6 | 4 | 3 | 32 | 0 | 75.0% | 8.00 | 10.67 | 39 | 1 | 1 | 0 | 0 | 116 |
| 7 | Trey BensonArizona Cardinals·#33 | 4 | 30 | 160 | 5.33 | 0 | 160 | 4 | 1 | 16 | 13 | 64 | 0 | 81.3% | 4.00 | 4.92 | 73 | 2 | 1 | 0 | 1 | 116 |
| 8 | Trayveon WilliamsCleveland Browns·#38 | 4 | 7 | 37 | 5.29 | 0 | 34 | 3 | 0 | 8 | 7 | 55 | 0 | 87.5% | 6.88 | 7.86 | 82 | 2 | 2 | 0 | 0 | 60 |
| 9 | Derrick HenryBaltimore Ravens·#22 | 17 | 308 | 1,595 | 5.18 | 16 | 921 | 80 | 27 | 20 | 15 | 150 | 0 | 75.0% | 7.50 | 10.00 | 135 | 2 | 2 | 0 | 4 | 534 |
| 10 | Jeremy McNicholsWashington Commanders·#26 | 17 | 45 | 232 | 5.16 | 1 | 230 | 13 | 2 | 32 | 25 | 196 | 0 | 78.1% | 6.12 | 7.84 | 222 | 3 | 2 | 0 | 2 | 296 |
| 11 | James CookBuffalo Bills·#4 | 17 | 314 | 1,612 | 5.13 | 12 | 1,039 | 70 | 16 | 40 | 33 | 291 | 2 | 82.5% | 7.28 | 8.82 | 272 | 3 | 3 | 1 | 5 | 605 |
| 12 | Blake CorumLos Angeles Rams·#22 | 17 | 147 | 746 | 5.07 | 6 | 350 | 45 | 13 | 14 | 8 | 36 | 0 | 57.1% | 2.57 | 4.50 | 37 | 1 | 0 | 0 | 1 | 315 |
| 13 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 293 | 1,474 | 5.03 | 7 | 1,110 | 65 | 12 | 103 | 79 | 820 | 4 | 76.7% | 7.96 | 10.38 | 857 | 13 | 9 | 3 | 6 | 818 |
| 14 | Jahmyr GibbsDetroit Lions·#0 | 17 | 248 | 1,223 | 4.93 | 13 | 706 | 57 | 10 | 94 | 77 | 613 | 5 | 81.9% | 6.52 | 7.96 | 612 | 15 | 12 | 5 | 3 | 699 |
| 15 | TreVeyon HendersonNew England Patriots·#32 | 17 | 184 | 902 | 4.90 | 9 | 374 | 45 | 8 | 42 | 35 | 221 | 1 | 83.3% | 5.26 | 6.31 | 244 | 4 | 4 | 1 | 2 | 471 |
| 16 | Justice HillBaltimore Ravens·#43 | 10 | 19 | 93 | 4.89 | 2 | 111 | 4 | 1 | 27 | 21 | 169 | 1 | 77.8% | 6.26 | 8.05 | 184 | 1 | 1 | 1 | 2 | 194 |
| 17 | J.K. DobbinsDenver Broncos·#27 | 10 | 158 | 772 | 4.89 | 4 | 428 | 37 | 7 | 14 | 11 | 42 | 0 | 78.6% | 3.00 | 3.82 | 56 | 0 | 0 | 0 | 1 | 327 |
| 18 | D'Andre SwiftChicago Bears·#4 | 16 | 224 | 1,087 | 4.85 | 9 | 615 | 63 | 14 | 48 | 34 | 290 | 1 | 70.8% | 6.04 | 8.53 | 348 | 1 | 1 | 0 | 4 | 598 |
| 19 | Malik DavisDallas Cowboys·#43 | 9 | 52 | 250 | 4.81 | 2 | 96 | 12 | 2 | 5 | 2 | 16 | 0 | 40.0% | 3.20 | 8.00 | 6 | 0 | 0 | 0 | 1 | 137 |
| 20 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 330 | 1,580 | 4.79 | 18 | 958 | 88 | 25 | 56 | 46 | 378 | 2 | 82.1% | 6.75 | 8.22 | 434 | 5 | 4 | 2 | 5 | 844 |
| 21 | Raheem MostertLas Vegas Raiders·#31 | 12 | 21 | 100 | 4.76 | 0 | 84 | 5 | 0 | 12 | 12 | 70 | 0 | 100.0% | 5.83 | 5.83 | 86 | 1 | 1 | 0 | 1 | 119 |
| 22 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 267 | 1,251 | 4.69 | 10 | 797 | 77 | 18 | 50 | 36 | 281 | 3 | 72.0% | 5.62 | 7.81 | 155 | 10 | 8 | 3 | 6 | 754 |
| 23 | Javonte WilliamsDallas Cowboys·#33 | 16 | 251 | 1,175 | 4.68 | 11 | 750 | 67 | 20 | 51 | 35 | 137 | 2 | 68.6% | 2.69 | 3.91 | 206 | 12 | 8 | 2 | 4 | 725 |
| 24 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 37 | 173 | 4.68 | 1 | 88 | 7 | 1 | 6 | 4 | 27 | 0 | 66.7% | 4.50 | 6.75 | 39 | 0 | 0 | 0 | 1 | 76 |
| 25 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 115 | 537 | 4.67 | 5 | 399 | 35 | 10 | 85 | 73 | 486 | 3 | 85.9% | 5.72 | 6.66 | 528 | 17 | 14 | 2 | 2 | 482 |
| 26 | Jordan MasonMinnesota Vikings·#27 | 16 | 164 | 758 | 4.62 | 6 | 472 | 47 | 7 | 16 | 14 | 51 | 0 | 87.5% | 3.19 | 3.64 | 102 | 1 | 1 | 0 | 3 | 397 |
| 27 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 13 | 60 | 4.62 | 1 | 32 | 3 | 1 | 17 | 16 | 99 | 0 | 94.1% | 5.82 | 6.19 | 105 | 1 | 1 | 0 | 0 | 77 |
| 28 | Kyle MonangaiChicago Bears·#25 | 17 | 172 | 783 | 4.55 | 5 | 424 | 43 | 12 | 30 | 18 | 164 | 0 | 60.0% | 5.47 | 9.11 | 162 | 3 | 2 | 0 | 0 | 458 |
| 29 | Rhamondre StevensonNew England Patriots·#38 | 14 | 133 | 605 | 4.55 | 7 | 406 | 29 | 12 | 38 | 32 | 347 | 2 | 84.2% | 9.13 | 10.84 | 263 | 6 | 5 | 1 | 4 | 493 |
| 30 | Ray DavisBuffalo Bills·#22 | 17 | 61 | 275 | 4.51 | 0 | 184 | 15 | 2 | 14 | 10 | 86 | 2 | 71.4% | 6.14 | 8.60 | 99 | 5 | 4 | 2 | 0 | 138 |
| 31 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 179 | 805 | 4.50 | 8 | 511 | 42 | 13 | 13 | 9 | 68 | 0 | 69.2% | 5.23 | 7.56 | 77 | 1 | 1 | 0 | 3 | 381 |
| 32 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 213 | 958 | 4.50 | 6 | 697 | 52 | 14 | 45 | 40 | 333 | 2 | 88.9% | 7.40 | 8.32 | 439 | 5 | 4 | 1 | 4 | 469 |
| 33 | Samaje PerineCincinnati Bengals·#34 | 15 | 85 | 382 | 4.49 | 3 | 263 | 34 | 4 | 21 | 17 | 87 | 0 | 81.0% | 4.14 | 5.12 | 109 | 1 | 1 | 0 | 3 | 314 |
| 34 | Jawhar JordanHouston Texans·#26 | 4 | 43 | 193 | 4.49 | 0 | 129 | 8 | 1 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 40 | 0 | 0 | 0 | 0 | 75 |
| 35 | Rico DowdleCarolina Panthers·#5 | 17 | 239 | 1,071 | 4.48 | 6 | 676 | 54 | 9 | 49 | 39 | 297 | 1 | 79.6% | 6.06 | 7.62 | 350 | 5 | 3 | 0 | 6 | 549 |
| 36 | David MontgomeryDetroit Lions·#5 | 17 | 161 | 718 | 4.46 | 8 | 441 | 42 | 17 | 29 | 24 | 192 | 0 | 82.8% | 6.62 | 8.00 | 199 | 2 | 1 | 0 | 5 | 392 |
| 37 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 112 | 500 | 4.46 | 6 | 309 | 32 | 14 | 4 | 3 | 30 | 0 | 75.0% | 7.50 | 10.00 | 26 | 1 | 0 | 0 | 2 | 237 |
| 38 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 229 | 1,015 | 4.43 | 5 | 583 | 49 | 8 | 36 | 31 | 282 | 0 | 86.1% | 7.83 | 9.10 | 339 | 3 | 2 | 0 | 5 | 466 |
| 39 | Tony PollardTennessee Titans·#20 | 17 | 246 | 1,079 | 4.39 | 5 | 659 | 48 | 5 | 41 | 33 | 206 | 0 | 80.5% | 5.02 | 6.24 | 203 | 1 | 1 | 0 | 9 | 636 |
| 40 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 93 | 400 | 4.30 | 2 | 229 | 21 | 2 | 12 | 8 | 25 | 0 | 66.7% | 2.08 | 3.12 | 35 | 4 | 3 | 0 | 0 | 169 |
| 41 | Breece HallNew York Jets·#20 | 16 | 245 | 1,048 | 4.28 | 4 | 532 | 56 | 4 | 48 | 36 | 350 | 1 | 75.0% | 7.29 | 9.72 | 321 | 9 | 2 | 0 | 4 | 590 |
| 42 | Chase BrownCincinnati Bengals·#30 | 17 | 241 | 1,019 | 4.23 | 6 | 734 | 53 | 13 | 88 | 69 | 439 | 5 | 78.4% | 4.99 | 6.36 | 427 | 11 | 8 | 5 | 4 | 698 |
| 43 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 136 | 572 | 4.21 | 4 | 332 | 40 | 9 | 45 | 40 | 218 | 0 | 88.9% | 4.84 | 5.45 | 329 | 10 | 9 | 0 | 4 | 532 |
| 44 | Audric EstiméNew Orleans Saints·#30 | 5 | 47 | 198 | 4.21 | 1 | 184 | 12 | 3 | 13 | 12 | 103 | 0 | 92.3% | 7.92 | 8.58 | 108 | 0 | 0 | 0 | 1 | 166 |
| 45 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 177 | 735 | 4.15 | 2 | 523 | 42 | 2 | 48 | 36 | 288 | 2 | 75.0% | 6.00 | 8.00 | 314 | 5 | 4 | 2 | 3 | 526 |
| 46 | Travis EtienneJacksonville Jaguars·#1 | 17 | 267 | 1,109 | 4.15 | 7 | 759 | 51 | 12 | 52 | 36 | 292 | 6 | 69.2% | 5.62 | 8.11 | 339 | 10 | 8 | 5 | 1 | 657 |
| 47 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 130 | 535 | 4.12 | 4 | 379 | 31 | 8 | 35 | 32 | 192 | 1 | 91.4% | 5.49 | 6.00 | 245 | 2 | 2 | 1 | 2 | 361 |
| 48 | Kendre MillerNew Orleans Saints·#5 | 7 | 47 | 193 | 4.11 | 1 | 156 | 9 | 0 | 5 | 5 | 30 | 0 | 100.0% | 6.00 | 6.00 | 35 | 0 | 0 | 0 | 1 | 105 |
| 49 | Kimani VidalLos Angeles Chargers·#30 | 13 | 157 | 643 | 4.10 | 3 | 337 | 36 | 7 | 22 | 16 | 136 | 1 | 72.7% | 6.18 | 8.50 | 170 | 6 | 3 | 1 | 0 | 455 |
| 50 | LeQuint Allen Jr.Jacksonville Jaguars·#36 | 17 | 23 | 94 | 4.09 | 0 | 67 | 5 | 1 | 11 | 10 | 54 | 0 | 90.9% | 4.91 | 5.40 | 61 | 2 | 2 | 0 | 4 | 229 |