| 1 | Bijan RobinsonAtlanta Falcons·#7 | 17 | 293 | 1,474 | 5.03 | 7 | 1,110 | 65 | 12 | 103 | 79 | 820 | 4 | 76.7% | 7.96 | 10.38 | 857 | 13 | 9 | 3 | 6 | 818 |
| 2 | James CookBuffalo Bills·#4 | 17 | 314 | 1,612 | 5.13 | 12 | 1,039 | 70 | 16 | 40 | 33 | 291 | 2 | 82.5% | 7.28 | 8.82 | 272 | 3 | 3 | 1 | 5 | 605 |
| 3 | Jonathan TaylorIndianapolis Colts·#28 | 17 | 330 | 1,580 | 4.79 | 18 | 958 | 88 | 25 | 56 | 46 | 378 | 2 | 82.1% | 6.75 | 8.22 | 434 | 5 | 4 | 2 | 5 | 844 |
| 4 | Derrick HenryBaltimore Ravens·#22 | 17 | 308 | 1,595 | 5.18 | 16 | 921 | 80 | 27 | 20 | 15 | 150 | 0 | 75.0% | 7.50 | 10.00 | 135 | 2 | 2 | 0 | 4 | 534 |
| 5 | De'Von AchaneMiami Dolphins·#28 | 16 | 240 | 1,350 | 5.62 | 8 | 822 | 58 | 5 | 84 | 67 | 481 | 4 | 79.8% | 5.73 | 7.18 | 545 | 11 | 7 | 3 | 3 | 658 |
| 6 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 274 | 972 | 3.55 | 4 | 813 | 45 | 10 | 73 | 55 | 349 | 5 | 75.3% | 4.78 | 6.35 | 452 | 10 | 9 | 4 | 1 | 732 |
| 7 | Christian McCaffreySan Francisco 49ers·#23 | 17 | 314 | 1,192 | 3.80 | 10 | 805 | 72 | 21 | 127 | 102 | 904 | 7 | 80.3% | 7.12 | 8.86 | 700 | 24 | 20 | 7 | 6 | 886 |
| 8 | Kyren WilliamsLos Angeles Rams·#23 | 17 | 267 | 1,251 | 4.69 | 10 | 797 | 77 | 18 | 50 | 36 | 281 | 3 | 72.0% | 5.62 | 7.81 | 155 | 10 | 8 | 3 | 6 | 754 |
| 9 | Travis EtienneJacksonville Jaguars·#1 | 17 | 267 | 1,109 | 4.15 | 7 | 759 | 51 | 12 | 52 | 36 | 292 | 6 | 69.2% | 5.62 | 8.11 | 339 | 10 | 8 | 5 | 1 | 657 |
| 10 | Javonte WilliamsDallas Cowboys·#33 | 16 | 251 | 1,175 | 4.68 | 11 | 750 | 67 | 20 | 51 | 35 | 137 | 2 | 68.6% | 2.69 | 3.91 | 206 | 12 | 8 | 2 | 4 | 725 |
| 11 | Chase BrownCincinnati Bengals·#30 | 17 | 241 | 1,019 | 4.23 | 6 | 734 | 53 | 13 | 88 | 69 | 439 | 5 | 78.4% | 4.99 | 6.36 | 427 | 11 | 8 | 5 | 4 | 698 |
| 12 | Jahmyr GibbsDetroit Lions·#0 | 17 | 248 | 1,223 | 4.93 | 13 | 706 | 57 | 10 | 94 | 77 | 613 | 5 | 81.9% | 6.52 | 7.96 | 612 | 15 | 12 | 5 | 3 | 699 |
| 13 | Jaylen WarrenPittsburgh Steelers·#30 | 16 | 213 | 958 | 4.50 | 6 | 697 | 52 | 14 | 45 | 40 | 333 | 2 | 88.9% | 7.40 | 8.32 | 439 | 5 | 4 | 1 | 4 | 469 |
| 14 | Josh JacobsGreen Bay Packers·#8 | 15 | 239 | 929 | 3.89 | 13 | 676 | 56 | 20 | 44 | 36 | 282 | 1 | 81.8% | 6.41 | 7.83 | 304 | 6 | 5 | 1 | 5 | 526 |
| 15 | Rico DowdleCarolina Panthers·#5 | 17 | 239 | 1,071 | 4.48 | 6 | 676 | 54 | 9 | 49 | 39 | 297 | 1 | 79.6% | 6.06 | 7.62 | 350 | 5 | 3 | 0 | 6 | 549 |
| 16 | Tony PollardTennessee Titans·#20 | 17 | 246 | 1,079 | 4.39 | 5 | 659 | 48 | 5 | 41 | 33 | 206 | 0 | 80.5% | 5.02 | 6.24 | 203 | 1 | 1 | 0 | 9 | 636 |
| 17 | D'Andre SwiftChicago Bears·#4 | 16 | 224 | 1,087 | 4.85 | 9 | 615 | 63 | 14 | 48 | 34 | 290 | 1 | 70.8% | 6.04 | 8.53 | 348 | 1 | 1 | 0 | 4 | 598 |
| 18 | Saquon BarkleyPhiladelphia Eagles·#26 | 16 | 274 | 1,103 | 4.03 | 7 | 608 | 50 | 14 | 51 | 37 | 273 | 2 | 72.5% | 5.35 | 7.38 | 296 | 8 | 5 | 1 | 3 | 712 |
| 19 | Kenneth Walker IIISeattle Seahawks·#9 | 17 | 229 | 1,015 | 4.43 | 5 | 583 | 49 | 8 | 36 | 31 | 282 | 0 | 86.1% | 7.83 | 9.10 | 339 | 3 | 2 | 0 | 5 | 466 |
| 20 | Quinshon JudkinsCleveland Browns·#10 | 14 | 238 | 829 | 3.48 | 7 | 581 | 51 | 13 | 36 | 26 | 171 | 0 | 72.2% | 4.75 | 6.58 | 194 | 1 | 1 | 0 | 1 | 435 |
| 21 | Breece HallNew York Jets·#20 | 16 | 245 | 1,048 | 4.28 | 4 | 532 | 56 | 4 | 48 | 36 | 350 | 1 | 75.0% | 7.29 | 9.72 | 321 | 9 | 2 | 0 | 4 | 590 |
| 22 | Tyrone Tracy Jr.New York Giants·#29 | 15 | 177 | 735 | 4.15 | 2 | 523 | 42 | 2 | 48 | 36 | 288 | 2 | 75.0% | 6.00 | 8.00 | 314 | 5 | 4 | 2 | 3 | 526 |
| 23 | Jacory Croskey-MerrittWashington Commanders·#22 | 17 | 179 | 805 | 4.50 | 8 | 511 | 42 | 13 | 13 | 9 | 68 | 0 | 69.2% | 5.23 | 7.56 | 77 | 1 | 1 | 0 | 3 | 381 |
| 24 | Zach CharbonnetSeattle Seahawks·#26 | 16 | 181 | 723 | 3.99 | 12 | 505 | 51 | 18 | 24 | 20 | 144 | 0 | 83.3% | 6.00 | 7.20 | 123 | 3 | 3 | 0 | 4 | 447 |
| 25 | Woody MarksHouston Texans·#27 | 16 | 204 | 703 | 3.45 | 2 | 492 | 42 | 9 | 36 | 24 | 208 | 3 | 66.7% | 5.78 | 8.67 | 223 | 8 | 5 | 3 | 0 | 542 |
| 26 | Jordan MasonMinnesota Vikings·#27 | 16 | 164 | 758 | 4.62 | 6 | 472 | 47 | 7 | 16 | 14 | 51 | 0 | 87.5% | 3.19 | 3.64 | 102 | 1 | 1 | 0 | 3 | 397 |
| 27 | David MontgomeryDetroit Lions·#5 | 17 | 161 | 718 | 4.46 | 8 | 441 | 42 | 17 | 29 | 24 | 192 | 0 | 82.8% | 6.62 | 8.00 | 199 | 2 | 1 | 0 | 5 | 392 |
| 28 | J.K. DobbinsDenver Broncos·#27 | 10 | 158 | 772 | 4.89 | 4 | 428 | 37 | 7 | 14 | 11 | 42 | 0 | 78.6% | 3.00 | 3.82 | 56 | 0 | 0 | 0 | 1 | 327 |
| 29 | Kyle MonangaiChicago Bears·#25 | 17 | 172 | 783 | 4.55 | 5 | 424 | 43 | 12 | 30 | 18 | 164 | 0 | 60.0% | 5.47 | 9.11 | 162 | 3 | 2 | 0 | 0 | 458 |
| 30 | Rhamondre StevensonNew England Patriots·#38 | 14 | 133 | 605 | 4.55 | 7 | 406 | 29 | 12 | 38 | 32 | 347 | 2 | 84.2% | 9.13 | 10.84 | 263 | 6 | 5 | 1 | 4 | 493 |
| 31 | RJ HarveyDenver Broncos·#12 | 17 | 150 | 540 | 3.60 | 7 | 404 | 30 | 10 | 58 | 47 | 356 | 5 | 81.0% | 6.14 | 7.57 | 360 | 11 | 9 | 4 | 1 | 456 |
| 32 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 177 | 588 | 3.32 | 1 | 404 | 29 | 1 | 35 | 30 | 282 | 3 | 85.7% | 8.06 | 9.40 | 360 | 4 | 3 | 1 | 1 | 414 |
| 33 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 126 | 496 | 3.94 | 3 | 401 | 32 | 4 | 18 | 15 | 101 | 0 | 83.3% | 5.61 | 6.73 | 133 | 3 | 1 | 0 | 0 | 305 |
| 34 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 115 | 537 | 4.67 | 5 | 399 | 35 | 10 | 85 | 73 | 486 | 3 | 85.9% | 5.72 | 6.66 | 528 | 17 | 14 | 2 | 2 | 482 |
| 35 | Omarion HamptonLos Angeles Chargers·#8 | 9 | 130 | 535 | 4.12 | 4 | 379 | 31 | 8 | 35 | 32 | 192 | 1 | 91.4% | 5.49 | 6.00 | 245 | 2 | 2 | 1 | 2 | 361 |
| 36 | Nick ChubbHouston Texans·#21 | 15 | 128 | 506 | 3.95 | 3 | 377 | 20 | 7 | 20 | 13 | 67 | 0 | 65.0% | 3.35 | 5.15 | 63 | 2 | 1 | 0 | 1 | 310 |
| 37 | TreVeyon HendersonNew England Patriots·#32 | 17 | 184 | 902 | 4.90 | 9 | 374 | 45 | 8 | 42 | 35 | 221 | 1 | 83.3% | 5.26 | 6.31 | 244 | 4 | 4 | 1 | 2 | 471 |
| 38 | Kareem HuntKansas City Chiefs·#29 | 17 | 164 | 611 | 3.73 | 8 | 367 | 55 | 15 | 24 | 18 | 143 | 1 | 75.0% | 5.96 | 7.94 | 153 | 4 | 2 | 1 | 1 | 498 |
| 39 | Aaron JonesMinnesota Vikings·#33 | 12 | 134 | 548 | 4.09 | 2 | 363 | 30 | 3 | 41 | 28 | 199 | 1 | 68.3% | 4.85 | 7.11 | 227 | 5 | 3 | 0 | 3 | 365 |
| 40 | Chuba HubbardCarolina Panthers·#30 | 15 | 137 | 511 | 3.73 | 1 | 358 | 31 | 2 | 39 | 30 | 223 | 3 | 76.9% | 5.72 | 7.43 | 291 | 6 | 4 | 1 | 3 | 413 |
| 41 | Alvin KamaraNew Orleans Saints·#41 | 11 | 134 | 471 | 3.51 | 1 | 355 | 22 | 2 | 39 | 33 | 212 | 0 | 84.6% | 5.44 | 6.42 | 202 | 5 | 4 | 0 | 6 | 436 |
| 42 | Blake CorumLos Angeles Rams·#22 | 17 | 147 | 746 | 5.07 | 6 | 350 | 45 | 13 | 14 | 8 | 36 | 0 | 57.1% | 2.57 | 4.50 | 37 | 1 | 0 | 0 | 1 | 315 |
| 43 | Kimani VidalLos Angeles Chargers·#30 | 13 | 157 | 643 | 4.10 | 3 | 337 | 36 | 7 | 22 | 16 | 136 | 1 | 72.7% | 6.18 | 8.50 | 170 | 6 | 3 | 1 | 0 | 455 |
| 44 | Tyler AllgeierAtlanta Falcons·#25 | 17 | 145 | 514 | 3.54 | 8 | 333 | 37 | 10 | 16 | 14 | 99 | 0 | 87.5% | 6.19 | 7.07 | 120 | 1 | 1 | 0 | 2 | 289 |
| 45 | Rachaad WhiteTampa Bay Buccaneers·#1 | 17 | 136 | 572 | 4.21 | 4 | 332 | 40 | 9 | 45 | 40 | 218 | 0 | 88.9% | 4.84 | 5.45 | 329 | 10 | 9 | 0 | 4 | 532 |
| 46 | Cam SkatteboNew York Giants·#44 | 8 | 106 | 412 | 3.89 | 5 | 321 | 29 | 10 | 32 | 24 | 207 | 2 | 75.0% | 6.47 | 8.62 | 209 | 4 | 3 | 2 | 2 | 262 |
| 47 | Chris Rodriguez Jr.Washington Commanders·#36 | 13 | 112 | 500 | 4.46 | 6 | 309 | 32 | 14 | 4 | 3 | 30 | 0 | 75.0% | 7.50 | 10.00 | 26 | 1 | 0 | 0 | 2 | 237 |
| 48 | Isiah PachecoKansas City Chiefs·#10 | 13 | 119 | 462 | 3.88 | 1 | 293 | 27 | 0 | 26 | 19 | 101 | 1 | 73.1% | 3.88 | 5.32 | 121 | 4 | 2 | 1 | 0 | 400 |
| 49 | Devin SingletaryNew York Giants·#26 | 17 | 123 | 437 | 3.55 | 5 | 285 | 28 | 10 | 19 | 18 | 151 | 0 | 94.7% | 7.95 | 8.39 | 162 | 2 | 2 | 0 | 1 | 288 |
| 50 | Tyjae SpearsTennessee Titans·#2 | 13 | 74 | 283 | 3.82 | 2 | 274 | 16 | 2 | 50 | 45 | 264 | 0 | 90.0% | 5.28 | 5.87 | 361 | 7 | 7 | 0 | 2 | 354 |