| 1 | Ameer AbdullahIndianapolis Colts·#26 | 13 | 13 | 60 | 4.62 | 1 | 32 | 3 | 1 | 17 | 16 | 99 | 0 | 94.1% | 5.82 | 6.19 | 105 | 1 | 1 | 0 | 0 | 77 |
| 2 | Austin EkelerWashington Commanders·#30 | 2 | 14 | 43 | 3.07 | 0 | 40 | 3 | 0 | 7 | 5 | 38 | 0 | 71.4% | 5.43 | 7.60 | 49 | 0 | 0 | 0 | 0 | 68 |
| 3 | Brian RobinsonSan Francisco 49ers·#3 | 17 | 93 | 400 | 4.30 | 2 | 229 | 21 | 2 | 12 | 8 | 25 | 0 | 66.7% | 2.08 | 3.12 | 35 | 4 | 3 | 0 | 0 | 169 |
| 4 | Chris BrooksGreen Bay Packers·#30 | 17 | 27 | 106 | 3.93 | 0 | 87 | 5 | 0 | 17 | 13 | 91 | 0 | 76.5% | 5.35 | 7.00 | 106 | 3 | 1 | 0 | 0 | 174 |
| 5 | Devin NealNew Orleans Saints·#24 | 9 | 57 | 206 | 3.61 | 2 | 103 | 11 | 2 | 19 | 17 | 104 | 0 | 89.5% | 5.47 | 6.12 | 138 | 1 | 1 | 0 | 0 | 243 |
| 6 | Emanuel WilsonGreen Bay Packers·#23 | 17 | 126 | 496 | 3.94 | 3 | 401 | 32 | 4 | 18 | 15 | 101 | 0 | 83.3% | 5.61 | 6.73 | 133 | 3 | 1 | 0 | 0 | 305 |
| 7 | James ConnerArizona Cardinals·#6 | 3 | 35 | 95 | 2.71 | 1 | 107 | 7 | 3 | 9 | 8 | 38 | 1 | 88.9% | 4.22 | 4.75 | 68 | 1 | 1 | 1 | 0 | 91 |
| 8 | Isiah PachecoKansas City Chiefs·#10 | 13 | 119 | 462 | 3.88 | 1 | 293 | 27 | 0 | 26 | 19 | 101 | 1 | 73.1% | 3.88 | 5.32 | 121 | 4 | 2 | 1 | 0 | 400 |
| 9 | Jawhar JordanHouston Texans·#26 | 4 | 43 | 193 | 4.49 | 0 | 129 | 8 | 1 | 7 | 7 | 34 | 0 | 100.0% | 4.86 | 4.86 | 40 | 0 | 0 | 0 | 0 | 75 |
| 10 | Jaydon BlueDallas Cowboys·#23 | 5 | 40 | 129 | 3.22 | 1 | 56 | 7 | 1 | 1 | 1 | 5 | 0 | 100.0% | 5.00 | 5.00 | 10 | 0 | 0 | 0 | 0 | 73 |
| 11 | Kimani VidalLos Angeles Chargers·#30 | 13 | 157 | 643 | 4.10 | 3 | 337 | 36 | 7 | 22 | 16 | 136 | 1 | 72.7% | 6.18 | 8.50 | 170 | 6 | 3 | 1 | 0 | 455 |
| 12 | Kyle MonangaiChicago Bears·#25 | 17 | 172 | 783 | 4.55 | 5 | 424 | 43 | 12 | 30 | 18 | 164 | 0 | 60.0% | 5.47 | 9.11 | 162 | 3 | 2 | 0 | 0 | 458 |
| 13 | Woody MarksHouston Texans·#27 | 16 | 204 | 703 | 3.45 | 2 | 492 | 42 | 9 | 36 | 24 | 208 | 3 | 66.7% | 5.78 | 8.67 | 223 | 8 | 5 | 3 | 0 | 542 |
| 14 | Raheim SandersCleveland Browns·#35 | 4 | 28 | 92 | 3.29 | 1 | 84 | 7 | 4 | 4 | 3 | 21 | 0 | 75.0% | 5.25 | 7.00 | 14 | 0 | 0 | 0 | 0 | 52 |
| 15 | Sean TuckerTampa Bay Buccaneers·#44 | 15 | 89 | 320 | 3.60 | 7 | 184 | 23 | 12 | 11 | 8 | 34 | 1 | 72.7% | 3.09 | 4.25 | 49 | 3 | 1 | 0 | 0 | 170 |
| 16 | Ray DavisBuffalo Bills·#22 | 17 | 61 | 275 | 4.51 | 0 | 184 | 15 | 2 | 14 | 10 | 86 | 2 | 71.4% | 6.14 | 8.60 | 99 | 5 | 4 | 2 | 0 | 138 |
| 17 | Tank BigsbyPhiladelphia Eagles·#37 | 11 | 56 | 306 | 5.46 | 1 | 220 | 16 | 6 | 4 | 3 | 32 | 0 | 75.0% | 8.00 | 10.67 | 39 | 1 | 1 | 0 | 0 | 116 |
| 18 | Trayveon WilliamsCleveland Browns·#38 | 4 | 7 | 37 | 5.29 | 0 | 34 | 3 | 0 | 8 | 7 | 55 | 0 | 87.5% | 6.88 | 7.86 | 82 | 2 | 2 | 0 | 0 | 60 |
| 19 | Will ShipleyPhiladelphia Eagles·#28 | 15 | 13 | 45 | 3.46 | 0 | 18 | 4 | 0 | 12 | 9 | 56 | 0 | 75.0% | 4.67 | 6.22 | 63 | 1 | 0 | 0 | 0 | 103 |
| 20 | Tyler BadieDenver Broncos·#28 | 16 | 8 | 23 | 2.88 | 0 | 53 | 1 | 1 | 31 | 19 | 141 | 0 | 61.3% | 4.55 | 7.42 | 210 | 4 | 3 | 0 | 0 | 180 |
| 21 | Zamir WhiteLas Vegas Raiders·#3 | 5 | 12 | 32 | 2.67 | 0 | 30 | 1 | 0 | 6 | 4 | 24 | 0 | 66.7% | 4.00 | 6.00 | 24 | 0 | 0 | 0 | 0 | 52 |
| 22 | Michael CarterArizona Cardinals·#22 | 13 | 95 | 333 | 3.51 | 1 | 266 | 20 | 4 | 45 | 33 | 267 | 0 | 73.3% | 5.93 | 8.09 | 257 | 7 | 4 | 0 | 1 | 384 |
| 23 | Kareem HuntKansas City Chiefs·#29 | 17 | 164 | 611 | 3.73 | 8 | 367 | 55 | 15 | 24 | 18 | 143 | 1 | 75.0% | 5.96 | 7.94 | 153 | 4 | 2 | 1 | 1 | 498 |
| 24 | Malik DavisDallas Cowboys·#43 | 9 | 52 | 250 | 4.81 | 2 | 96 | 12 | 2 | 5 | 2 | 16 | 0 | 40.0% | 3.20 | 8.00 | 6 | 0 | 0 | 0 | 1 | 137 |
| 25 | Jaylen WrightMiami Dolphins·#5 | 10 | 71 | 288 | 4.06 | 2 | 223 | 18 | 4 | 9 | 5 | 44 | 0 | 55.6% | 4.89 | 8.80 | 60 | 0 | 0 | 0 | 1 | 116 |
| 26 | J.K. DobbinsDenver Broncos·#27 | 10 | 158 | 772 | 4.89 | 4 | 428 | 37 | 7 | 14 | 11 | 42 | 0 | 78.6% | 3.00 | 3.82 | 56 | 0 | 0 | 0 | 1 | 327 |
| 27 | Keaton MitchellBaltimore Ravens·#34 | 13 | 61 | 341 | 5.59 | 1 | 184 | 16 | 0 | 12 | 9 | 63 | 0 | 75.0% | 5.25 | 7.00 | 85 | 0 | 0 | 0 | 1 | 120 |
| 28 | Jaleel McLaughlinDenver Broncos·#38 | 8 | 37 | 173 | 4.68 | 1 | 88 | 7 | 1 | 6 | 4 | 27 | 0 | 66.7% | 4.50 | 6.75 | 39 | 0 | 0 | 0 | 1 | 76 |
| 29 | Brashard SmithKansas City Chiefs·#24 | 17 | 45 | 151 | 3.36 | 0 | 144 | 6 | 1 | 35 | 25 | 185 | 1 | 71.4% | 5.29 | 7.40 | 232 | 7 | 6 | 1 | 1 | 164 |
| 30 | Bucky IrvingTampa Bay Buccaneers·#7 | 10 | 177 | 588 | 3.32 | 1 | 404 | 29 | 1 | 35 | 30 | 282 | 3 | 85.7% | 8.06 | 9.40 | 360 | 4 | 3 | 1 | 1 | 414 |
| 31 | Bhayshul TutenJacksonville Jaguars·#33 | 15 | 85 | 307 | 3.61 | 5 | 217 | 23 | 8 | 14 | 10 | 79 | 2 | 71.4% | 5.64 | 7.90 | 80 | 2 | 2 | 2 | 1 | 201 |
| 32 | Audric EstiméNew Orleans Saints·#30 | 5 | 47 | 198 | 4.21 | 1 | 184 | 12 | 3 | 13 | 12 | 103 | 0 | 92.3% | 7.92 | 8.58 | 108 | 0 | 0 | 0 | 1 | 166 |
| 33 | Quinshon JudkinsCleveland Browns·#10 | 14 | 238 | 829 | 3.48 | 7 | 581 | 51 | 13 | 36 | 26 | 171 | 0 | 72.2% | 4.75 | 6.58 | 194 | 1 | 1 | 0 | 1 | 435 |
| 34 | Ollie Gordon IIMiami Dolphins·#31 | 17 | 70 | 199 | 2.84 | 3 | 114 | 21 | 6 | 9 | 7 | 32 | 1 | 77.8% | 3.56 | 4.57 | 57 | 2 | 2 | 1 | 1 | 196 |
| 35 | Nick ChubbHouston Texans·#21 | 15 | 128 | 506 | 3.95 | 3 | 377 | 20 | 7 | 20 | 13 | 67 | 0 | 65.0% | 3.35 | 5.15 | 63 | 2 | 1 | 0 | 1 | 310 |
| 36 | Raheem MostertLas Vegas Raiders·#31 | 12 | 21 | 100 | 4.76 | 0 | 84 | 5 | 0 | 12 | 12 | 70 | 0 | 100.0% | 5.83 | 5.83 | 86 | 1 | 1 | 0 | 1 | 119 |
| 37 | Miles SandersDallas Cowboys·#24 | 4 | 21 | 117 | 5.57 | 1 | 76 | 7 | 1 | 8 | 8 | 30 | 0 | 100.0% | 3.75 | 3.75 | 44 | 1 | 1 | 0 | 1 | 63 |
| 38 | RJ HarveyDenver Broncos·#12 | 17 | 150 | 540 | 3.60 | 7 | 404 | 30 | 10 | 58 | 47 | 356 | 5 | 81.0% | 6.14 | 7.57 | 360 | 11 | 9 | 4 | 1 | 456 |
| 39 | Travis EtienneJacksonville Jaguars·#1 | 17 | 267 | 1,109 | 4.15 | 7 | 759 | 51 | 12 | 52 | 36 | 292 | 6 | 69.2% | 5.62 | 8.11 | 339 | 10 | 8 | 5 | 1 | 657 |
| 40 | Kendre MillerNew Orleans Saints·#5 | 7 | 47 | 193 | 4.11 | 1 | 156 | 9 | 0 | 5 | 5 | 30 | 0 | 100.0% | 6.00 | 6.00 | 35 | 0 | 0 | 0 | 1 | 105 |
| 41 | DJ GiddensIndianapolis Colts·#21 | 6 | 27 | 96 | 3.56 | 0 | 60 | 5 | 1 | 2 | 0 | 0 | 0 | 0.0% | 0.00 | — | 0 | 1 | 0 | 0 | 1 | 57 |
| 42 | Jaret PattersonLos Angeles Chargers·#32 | 6 | 41 | 159 | 3.88 | 1 | 110 | 7 | 2 | 4 | 3 | 8 | 0 | 75.0% | 2.00 | 2.67 | 8 | 0 | 0 | 0 | 1 | 103 |
| 43 | Evan HullNew Orleans Saints·#34 | 6 | 19 | 47 | 2.47 | 0 | 20 | 3 | 0 | 1 | 1 | 6 | 0 | 100.0% | 6.00 | 6.00 | 10 | 0 | 0 | 0 | 1 | 70 |
| 44 | Devin SingletaryNew York Giants·#26 | 17 | 123 | 437 | 3.55 | 5 | 285 | 28 | 10 | 19 | 18 | 151 | 0 | 94.7% | 7.95 | 8.39 | 162 | 2 | 2 | 0 | 1 | 288 |
| 45 | Blake CorumLos Angeles Rams·#22 | 17 | 147 | 746 | 5.07 | 6 | 350 | 45 | 13 | 14 | 8 | 36 | 0 | 57.1% | 2.57 | 4.50 | 37 | 1 | 0 | 0 | 1 | 315 |
| 46 | Trey BensonArizona Cardinals·#33 | 4 | 30 | 160 | 5.33 | 0 | 160 | 4 | 1 | 16 | 13 | 64 | 0 | 81.3% | 4.00 | 4.92 | 73 | 2 | 1 | 0 | 1 | 116 |
| 47 | Ty JohnsonBuffalo Bills·#26 | 17 | 50 | 200 | 4.00 | 3 | 160 | 13 | 6 | 33 | 24 | 231 | 2 | 72.7% | 7.00 | 9.62 | 269 | 4 | 2 | 1 | 1 | 302 |
| 48 | Zavier ScottMinnesota Vikings·#36 | 9 | 33 | 114 | 3.45 | 0 | 82 | 6 | 1 | 15 | 14 | 98 | 1 | 93.3% | 6.53 | 7.00 | 105 | 3 | 3 | 1 | 1 | 98 |
| 49 | Ashton JeantyLas Vegas Raiders·#2 | 17 | 274 | 972 | 3.55 | 4 | 813 | 45 | 10 | 73 | 55 | 349 | 5 | 75.3% | 4.78 | 6.35 | 452 | 10 | 9 | 4 | 1 | 732 |
| 50 | Kenneth GainwellPittsburgh Steelers·#14 | 17 | 115 | 537 | 4.67 | 5 | 399 | 35 | 10 | 85 | 73 | 486 | 3 | 85.9% | 5.72 | 6.66 | 528 | 17 | 14 | 2 | 2 | 482 |